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Anaes TopicsApplied anatomy

Anaes · Applied anatomy

Brachial plexus anatomy

Also known as Brachial plexus · Interscalene block · Supraclavicular block · Infraclavicular block · Axillary block · Erb palsy

The brachial plexus supplies the entire upper limb and is the most blocked nerve structure in regional anaesthesia. Its anatomy is taught as a five-stage sequence — roots, trunks, divisions, cords and branches — that maps directly onto the four classic approaches to plexus blockade. The framework rests on six exam-critical ideas. First, the plexus is formed by the ventral rami of C5, C6, C7, C8 and T1 (the roots), which unite into three trunks: the upper trunk (C5-C6), the middle trunk (C7) and the lower trunk (C8-T1). Second, each trunk splits into an anterior and a posterior division; the six divisions regroup into three cords named by their relationship to the axillary artery — the lateral, medial and posterior cords. Third, the cords give rise to five terminal branches: the musculocutaneous nerve (lateral cord, elbow flexors and lateral forearm), the axillary nerve (posterior cord, deltoid and teres minor), the radial nerve (posterior cord, all the extensor compartment of arm and forearm), the median nerve (lateral and medial cords, most of the thenar muscles and lateral palm) and the ulnar nerve (medial cord, the intrinsic hand muscles and medial one and a half digits). Fourth, the plexus runs a recognisable course — between the scalenus anterior and medius (the interscalene groove), over the first rib, behind the clavicle, and into the axilla around the axillary artery — and each location is the site of a named block. Fifth, the four classic ultrasound-guided approaches are interscalene (roots/trunks, shoulder surgery but with a high rate of phrenic-nerve block), supraclavicular (divisions, the whole upper limb, near the pleura), infraclavicular/costoclavicular (cords around the axillary artery, hand and forearm surgery) and axillary (branches, forearm and hand). Sixth, two birth-injury patterns localise damage: Erb's palsy (upper trunk C5-C6, the waiter's-tip posture) and Klumpke's palsy (lower trunk C8-T1, a claw hand and sometimes Horner syndrome). Built on the ultrasound-guided interscalene block study (Soor 2026), the diaphragm-sparing low-volume interscalene study (Verbeke 2026), the selective-trunk and supraclavicular block study (Rani 2026), the costoclavicular versus infraclavicular block study (Yazar 2026), the axillary-plexus-blockade study (Solomos 2025), the obstetric brachial-plexus-palsy study (Cimilli 2026), the musculocutaneous-nerve-variation study (Lv 2026), and the greater-auricular-nerve imaging study (Kabra 2026).

high8 referencesUpdated 10 July 2026
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Red flags

The brachial plexus is taught as a five-stage sequence: ROOTS (C5-T1 ventral rami) → TRUNKS (upper C5-6, middle C7, lower C8-T1) → DIVISIONS (anterior and posterior from each trunk) → CORDS (lateral, medial, posterior, named by relation to the axillary artery) → BRANCHES (musculocutaneous, axillary, radial, median, ulnar). Mnemonic: Read That Damn Cadaver.The five terminal branches and their cords: musculocutaneous and part of median (lateral cord); axillary and radial (posterior cord); ulnar and part of median (medial cord). The median nerve has contributions from BOTH the lateral and medial cords (the 'M' shape).The four classic US-guided block sites track the plexus along its course: interscalene (roots/trunks, shoulder, high phrenic-block risk), supraclavicular (divisions, the whole limb, pleural-puncture risk), infraclavicular/costoclavicular (cords, forearm/hand), axillary (branches, forearm/hand).The INTERSCALENE block predictably blocks the ipsilateral PHRENIC NERVE (C3-C5) in a high fraction of patients, causing hemidiaphragmatic paresis — avoid it in respiratory-compromised patients; low-volume or low-dose techniques reduce but do not abolish the risk.Erb's palsy is an UPPER-TRUNK (C5-C6) injury producing the 'waiter's tip' posture (arm adducted, internally rotated, elbow extended, forearm pronated, wrist flexed). Klumpke's palsy is a LOWER-TRUNK (C8-T1) injury producing a claw hand, sometimes with Horner syndrome if the T1 sympathetic fibres are involved.Anatomical VARIATION is common at the plexus — most notably the musculocutaneous nerve, which may pierce the coracobrachialis late or run with the median nerve (a communicating branch) — and ultrasound will identify these variants pre-procedure.

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ANZCAFRCAABAEDAICFCAIFCA_SA

Red flags

The brachial plexus is taught as a five-stage sequence: ROOTS (C5-T1 ventral rami) → TRUNKS (upper C5-6, middle C7, lower C8-T1) → DIVISIONS (anterior and posterior from each trunk) → CORDS (lateral, medial, posterior, named by relation to the axillary artery) → BRANCHES (musculocutaneous, axillary, radial, median, ulnar). Mnemonic: Read That Damn Cadaver.The five terminal branches and their cords: musculocutaneous and part of median (lateral cord); axillary and radial (posterior cord); ulnar and part of median (medial cord). The median nerve has contributions from BOTH the lateral and medial cords (the 'M' shape).The four classic US-guided block sites track the plexus along its course: interscalene (roots/trunks, shoulder, high phrenic-block risk), supraclavicular (divisions, the whole limb, pleural-puncture risk), infraclavicular/costoclavicular (cords, forearm/hand), axillary (branches, forearm/hand).The INTERSCALENE block predictably blocks the ipsilateral PHRENIC NERVE (C3-C5) in a high fraction of patients, causing hemidiaphragmatic paresis — avoid it in respiratory-compromised patients; low-volume or low-dose techniques reduce but do not abolish the risk.Erb's palsy is an UPPER-TRUNK (C5-C6) injury producing the 'waiter's tip' posture (arm adducted, internally rotated, elbow extended, forearm pronated, wrist flexed). Klumpke's palsy is a LOWER-TRUNK (C8-T1) injury producing a claw hand, sometimes with Horner syndrome if the T1 sympathetic fibres are involved.Anatomical VARIATION is common at the plexus — most notably the musculocutaneous nerve, which may pierce the coracobrachialis late or run with the median nerve (a communicating branch) — and ultrasound will identify these variants pre-procedure.

Key answer

Brachial plexus = C5–T1 ventral rami → trunks → divisions → cords → five terminal branches. Four classic US blocks track the course: interscalene (roots/trunks, shoulder, phrenic risk), supraclavicular (divisions, whole limb, pleural risk), infraclavicular/costoclavicular (cords), axillary (branches). Mnemonic: Read That Damn Cadaver.
[1]
Brachial plexus as a branching network from neck to arm
FigureThe brachial plexus: roots between the scalenes, trunks over the first rib, cords around the axillary artery — the most blocked nerve structure in regional anaesthesia.

Why this matters to the anaesthetist

The brachial plexus is the single most frequently blocked nerve structure in regional anaesthesia. Every upper-limb block — shoulder, arm, forearm, hand — is an exercise in knowing which stage of the five-stage sequence sits at which anatomical location, which nerves will and will not be covered, and which vital structures sit next door (phrenic nerve, pleura, subclavian artery, vertebral artery). The viva rewards exact relations and block-choice logic, not generic "block the plexus" answers [1][2].

The five-stage organisation (Read That Damn Cadaver)

StageElementsLocationBlock target
RootsC5, C6, C7, C8, T1 ventral ramiInterscalene groove (between scalenus anterior and medius)Interscalene
TrunksUpper (C5–6), middle (C7), lower (C8–T1)Posterior triangle; cross over first ribInterscalene / selective trunk
DivisionsAnterior + posterior from each trunk (six total)Behind the clavicleSupraclavicular
CordsLateral, medial, posterior — named by relation to axillary arteryInfraclavicular / costoclavicular regionInfraclavicular, costoclavicular
BranchesMusculocutaneous, axillary, radial, median, ulnarAxilla around axillary arteryAxillary

Prefixed plexus = C4 contribution; postfixed = T2 contribution. Both alter dermatome maps slightly and are best recognised under ultrasound [7].

M-shaped schematic of brachial plexus roots trunks divisions cords branches
FigureClassic M-shape: roots form trunks, trunks split into divisions, divisions regroup into cords around the axillary artery, cords give five terminal branches. The median nerve forms the middle of the M.

Exact relations along the course

LevelKey relationsClinical hazard
Interscalene grooveRoots between scalenus anterior (anterior) and scalenus medius (posterior); phrenic nerve on anterior surface of scalenus anterior; vertebral artery medial/deepPhrenic block (hemidiaphragm); vertebral artery injection → seizure
SupraclavicularDivisions as "cluster of grapes" superolateral to subclavian artery; pleural dome immediately inferior/medial; first rib is deep landmarkPneumothorax; arterial puncture
Infraclavicular / costoclavicularCords around axillary artery deep to pectoralis minor (infraclavicular) or between clavicle and second rib (costoclavicular)Pneumothorax (lower risk than supra); vessel puncture
AxillaryMedian, ulnar, radial around axillary artery; musculocutaneous usually in coracobrachialis (separate)Incomplete block if musculocutaneous missed

Definition

At the interscalene groove the phrenic nerve (C3–C5) runs on the anterior surface of scalenus anterior — almost always blocked by a classical interscalene injection. Low-volume techniques reduce but do not abolish hemidiaphragmatic paresis [2].

Terminal branches — origin, motor, sensory

BranchCordMotorSensoryBlock implication
MusculocutaneousLateralBiceps, brachialis, coracobrachialis (elbow flexion, supination)Lateral forearm (lateral cutaneous n. of forearm)Must be found separately in axillary block
AxillaryPosteriorDeltoid, teres minorRegimental-badge patch over deltoidCovered by interscalene / supra; missed by pure axillary
RadialPosteriorTriceps + all wrist/finger extensorsPosterior arm/forearm, dorsolateral handPosterior cord coverage critical for tourniquet pain and extensors
MedianLateral + medial rootsLOAF thenar muscles, most forearm flexorsLateral palm, lateral 3½ digitsThe "M" of the plexus — dual cord origin
UlnarMedialMost intrinsic hand muscles, FCU, medial FDPMedial 1½ digits, medial palmLower trunk / medial cord — often missed by interscalene

Read That Damn Cadaver

RTDC

R Roots

C5–T1 ventral rami

T Trunks

Upper, middle, lower

D Divisions

Anterior and posterior

C Cords

Lateral, medial, posterior

B Branches

Five terminal nerves

LOAF — median motor hand

LOAF

L Lumbricals 1–2

Median motor

O Opponens pollicis

Thenar

A Abductor pollicis brevis

Thenar

F Flexor pollicis brevis

Thenar (superficial head)

The four classic ultrasound-guided blocks

BlockTarget levelSurgical coverageLandmark / sonoMain caveatTypical volume (adult)
InterscaleneRoots / upper trunk (C5–C6)Shoulder, proximal humerusShort-axis: 2–3 hypoechoic roots between scalenesPhrenic block; misses C8–T1 (ulnar)7–15 mL (low-volume preferred) [1][2]
SupraclavicularDivisionsWhole upper limb distal to shoulderCluster of grapes superolateral to subclavian a.; pleura deepPneumothorax15–25 mL [3]
Infraclavicular / costoclavicularCordsForearm, hand; good catheter siteCords around axillary a.; costoclavicular more compactLess phrenic risk; vessel puncture20–30 mL [4]
AxillaryTerminal branchesForearm, hand (not shoulder)Nerves around axillary a.; locate MC in coracobrachialisMissed musculocutaneous; no shoulder cover15–25 mL + MC top-up [5]

Interscalene

  • Shoulder surgery first choice
  • High phrenic-block rate
  • Misses ulnar (C8–T1)
  • Avoid severe respiratory disease

Supraclavicular

  • Whole-limb from one injection
  • Fast onset
  • Pleural risk
  • Good when shoulder not needed

Infraclavicular / costoclavicular

  • Cords around artery
  • Reliable catheters
  • Costoclavicular more compact spread
  • Lower phrenic risk

Axillary

  • Safest for respiratory risk
  • Forearm/hand only
  • Must block musculocutaneous separately
  • Add intercostobrachial for tourniquet

Ultrasound sonoanatomy — exam points

  • Interscalene: linear probe, short-axis, mid-neck. Scalenus anterior and medius form a "stoplight" of 2–3 hypoechoic roots. Identify carotid artery medially; keep needle tip lateral to vessels. Greater auricular nerve may be seen superficial over scalenus medius [8].
  • Supraclavicular: probe in supraclavicular fossa parallel to clavicle. Subclavian artery is the landmark; plexus sits superolateral ("grapes"); first rib and pleural line are deep — never inject below the rib line.
  • Axillary: probe high in axilla short-axis to artery. Median (superficial), ulnar (medial), radial (deep/posterior) around artery; musculocutaneous as hyperechoic oval in coracobrachialis — find it deliberately or the lateral forearm wakes up [7].

Injuries examiners love

  • Erb's palsy (upper trunk C5–C6): waiter's tip — arm adducted, internally rotated, elbow extended, forearm pronated, wrist flexed. Birth traction or motorcycle fall.
  • Klumpke's palsy (lower trunk C8–T1): claw hand ± ipsilateral Horner syndrome if T1 sympathetics involved [6].
  • Inadvertent intraneural / arterial injection and local anaesthetic systemic toxicity are procedure hazards, not plexus anatomy — but the vertebral artery proximity at interscalene makes seizure risk real.

Variation that changes the block

Musculocutaneous nerve may pierce coracobrachialis late, run with the median nerve, or send a communicating branch — the commonest reason an axillary block misses the lateral forearm [7]. Prefixed/postfixed plexuses and anomalous cord formation are recognised under ultrasound before injection.

SAQ answer scaffold

  1. Draw/list the five stages (roots → trunks → divisions → cords → branches) with root contributions.
  2. Name the five terminal branches with cord of origin, motor and sensory.
  3. For a given operation (e.g. shoulder arthroscopy vs wrist ORIF), choose the block and justify coverage and risks.
  4. Explain why interscalene causes hemidiaphragmatic paresis and how to mitigate.
  5. State how you would complete an axillary block if the lateral forearm remains intact. [1]

Viva stem bank and model phrases

  • "Describe the course of the brachial plexus from foramina to axilla." → "C5–T1 roots unite in the interscalene groove between scalenus anterior and medius; trunks cross the posterior triangle over the first rib; divisions form behind the clavicle; cords surround the axillary artery; terminal branches arise in the axilla."
  • "Why prefer costoclavicular over classic infraclavicular?" → "Cords are more tightly clustered between clavicle and second rib, improving single-injection spread and catheter stability [4]."
  • "Patient with severe COPD needs shoulder surgery — what do you avoid?" → "Classical interscalene because of near-universal phrenic block; discuss alternative (superior trunk low-volume, general alone, or carefully counselled low-volume techniques)."

Common traps

  • Thinking interscalene covers the whole arm including ulnar — it often spares C8–T1.
  • Forgetting to block musculocutaneous separately at the axilla.
  • Ignoring phrenic risk in COPD / obesity / contralateral phrenic palsy.
  • Confusing Erb (upper trunk, waiter's tip) with Klumpke (lower trunk, claw ± Horner).
  • Injecting deep to the first rib at the supraclavicular level (pleura). [1]
Block sites along brachial plexus course
FigureBlock sites mapped to plexus stages: interscalene at roots/trunks, supraclavicular at divisions, infraclavicular at cords, axillary at branches.

Clinical pearl

When the interscalene misses the ulnar side of the hand, that is anatomy doing its job — the lower trunk is distant from a C5–C6-focused injection. Either accept incomplete distal cover for shoulder surgery, or add a selective lower-trunk/supraclavicular top-up if distal work is planned.
[1]

Red flags

Red flag

ROOTS → TRUNKS → DIVISIONS → CORDS → BRANCHES (Read That Damn Cadaver). Median nerve has dual cord origin (the M).

Red flag

Interscalene: shoulder cover, high phrenic-block rate, often misses ulnar. Avoid or modify in respiratory compromise.

Red flag

Supraclavicular: whole limb, but pleural dome is immediately deep — pneumothorax risk.

Red flag

Axillary: always locate musculocutaneous in coracobrachialis separately.

Red flag

Erb = C5–C6 waiter's tip; Klumpke = C8–T1 claw ± Horner.
[1]

References

  1. [1]Soor B, et al. Ultrasound-guided Interscalene Block as a Safer Alternative to General Anesthesia in a Patient with Ankylosing Spondylitis Undergoing Proximal Humerus Fracture Fixation Ann Afr Med, 2026.PMID 42318963
  2. [2]Verbeke AL, et al. The diaphragm-sparing effect of interscalene block with a low-volume of ropivacaine 0.1% vs. 0.5%: A double-blind, controlled, randomised trial Eur J Anaesthesiol Intensive Care, 2026.PMID 42244823
  3. [3]Rani N, et al. Ultrasound-Guided Selective Trunk Block Combined With Supraclavicular Nerve Block for Awake Shoulder Arthroscopy: A Case Series Cureus, 2026.PMID 42220761
  4. [4]Yazar V, et al. Comparison of Costoclavicular Block and Infraclavicular Block Effects on Tissue Oxygen Saturation in Upper Extremity Surgery: A Randomized, Assessor-Blinded Controlled Trial Diagnostics (Basel), 2026.PMID 42279582
  5. [5]Solomos D, et al. Effect of Ketamine Supplementation in Axillary Plexus Blockade: A Comparative Study Cureus, 2025.PMID 41583169
  6. [6]Cimilli E, et al. Cognitive and Executive Function Profiles in School‑Age Children with Obstetric Brachial Plexus Injury Phys Occup Ther Pediatr, 2026.PMID 42322142
  7. [7]Lv Y, et al. An anatomical variation of the musculocutaneous nerve featuring early bifurcation and a transient common trunk with the median nerve: a case report Folia Morphol (Warsz), 2026.PMID 42345218
  8. [8]Kabra N, et al. Asymmetrical Brachial Plexus Involvement with Greater Auricular Nerve Involvement in Borderline Tuberculoid Leprosy: An Electrophysiological and Radiological Correlation Indian J Radiol Imaging, 2026.PMID 42344197