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Chemical, biological, radiological and nuclear (CBRN) mass casualty

The CBRN event inverts several standard rules. The casualty is contaminated — the responder who touches the casualty without PPE becomes the next casualty, and the hospital that accepts an un-decontaminated casualty closes itself. The triage is performed through PPE (gloves, suit, respirator), the life-saving interventions are restricted (no mouth-to-mouth, no needle decompression through a suit — use autoinjectors), and the casualty is decontaminated before they enter the clean zone of the hospital.[1]

CBRN — strip and decontaminate before any clinical care

  1. HOT ZONE / WARM ZONE / COLD ZONE — Set up the three zones before accepting casualties. The hot zone is the contaminated scene; the warm zone is the decontamination corridor; the cold zone is the clean clinical area. No casualty crosses hot→cold without decontamination.
  2. STRIP — Clothing removal eliminates 80–90% of contamination. This is the single most effective intervention and is performed before any rinse.
  3. RINSE-WIPE-RINSE — Copious warm water (hypothermia in cold-water decontamination is a real killer), then soap, then rinse again. Ambulant casualties self-decontaminate; the non-ambulant go through the decontamination tent.
  4. ANTIDOTE EARLY — Nerve agent: atropine + oxime autoinjectors (the NATO combo-pen / DuoDote); cyanide: hydroxocobalamin; organophosphate: benzodiazepine for seizures. The clinical sign drives the antidote, not the assay — the cholinergic toxidrome (miosis, salivation, lacrimation, fasciculations) is diagnostic.
  5. HOSPITAL LOCKDOWN — The hospital activates its CBRN plan, locks the doors, sets up the decontamination structure outside the ED, and accepts casualties only through the decontamination corridor. A contaminated casualty who breaches the ED closes the hospital.
  6. REVERSE TRIAGE for the agent — For nerve agents the most cyanotic / bradypnoeic casualty is the most reversible (the antidote works in minutes). The standard "expectant" may rapidly become "immediate" with atropine.
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Hospital major incident plan — activation and the cascade

The hospital major incident plan (the Major Incident Plan, the Disaster Plan, Code Brown in Australasia) is the standing document that pre-allocates roles, locations and the chain of activation. It is activated by a defined trigger (the METHANE message, the standing-order activation criteria, or the explicit declaration by the senior emergency physician or the on-call executive), and the activation is the declaration — not the assessment. The plan assumes the staff on duty will not know their roles; the document does.[1]

Hospital major incident — the activation cascade

  1. DECLARATION — The senior ED consultant or on-call executive declares the major incident using the trigger criteria (any incident where the demand exceeds the available resources). The declaration activates the plan; it does not wait for confirmation.
  2. METHANE MESSAGE — The standard structured message to all receiving agencies: Major incident declared, Exact location, Type (chemical / explosive / mass casualty), Hazards, Access (in/out routes), Number of casualties (estimated), Emergency services required.
  3. CASCADE ACTIVATION — Switchboard triggers the cascade — the major incident team (incident commander, medical commander, matron, portering, security, theatre coordinator, ICU consultant, radiology, laboratory, mortuary, communications).
  4. ICU ALERT — ICU consultant on site within 30–60 min; ICU bed state reviewed; surge capacity activated.
  5. CREATE CAPACITY — The ED creates trolley space: ambulant casualties to the front hall; stable admitted patients to the wards; elective theatres converted to emergency; the day-case unit to a holding ward.
  6. ESTABLISH THE TRIAGE POINT — A single triage officer at the ED door, re-sorting casualties as they arrive (they will arrive before the official notification — the "self-presenters" arrive by private car, often the most urgent).
  7. COMMUNICATIONS CELL — A single point for media, family enquiries and inter-hospital coordination. No clinical staff talks to media; all enquiries routed to the cell.
  8. STAND-DOWN — When the casualty flow is contained and the inpatients are placed, the incident commander stands the plan down. A hot debrief is held within 24 h.[1]

ICU surge capacity — the three tiers and the reverse-triage ladder

The ICU is the rate-limiting step in any major incident — the ED can absorb a surge by discharging and doubling up, the theatre can run extra lists, but the ICU cannot create trained nurses. The surge capacity is conventionally defined in three tiers — conventional, contingent and crisis capacity — corresponding to the staff, space and supplies available at each level.[6]

The three tiers of ICU surge capacity
TierStaffing modelSpaceIndication
TierStaffing modelSpaceIndication
ConventionalUsual ICU nurse-to-patient ratio (1:1 for the ventilated)Usual ICU bedsRoutine surge — seasonal, predictable
ContingentModified ratios (1:2 or 1:3 for the stable ventilated; supervised non-ICU nurses)Post-anaesthetic care unit (PACU), HDU, theatre recovery opened as surge ICUModerate incident; cancel electives; transfer out where possible
CrisisCrisis standards — any trained staff (operating department practitioners, redeployed ward nurses under ICU supervision); 1:4 or worseAny monitored bed; the operating theatre becomes ICU overflow; cohorting of casualtiesMass casualty or pandemic overwhelm — reverse triage in force
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ICU surge — the capacity-creation ladder (in order)

  1. CANCEL ELECTIVE WORK — The fastest single intervention: cancel elective surgery, elective admissions and outpatient work; the staff and the PACU/recovery space become available within hours.
  2. EXPEDITE DISCHARGE — Every patient reviewed for step-down to HDU or ward; palliative / withdrawal decisions expedited where appropriate.
  3. OPEN THE PACU AND THEATRE RECOVERY as ICU overflow — monitored spaces with anaesthetic-trained staff; ideal for the stabilised trauma casualty.
  4. DOUBLE-BED / SINGLE-ROOM CONVERSION — Convert single rooms to double occupancy; cohort casualties by mechanism where contamination is a concern.
  5. REDEPLOY STAFF — Recovered theatre staff, ward nurses, retired staff recalled. Operate to a crisis staffing model with clear scope-of-practice and supervision.
  6. MUTUAL AID — INTRA-NETWORK TRANSFER — Move the stable ICU patients out to a non-receiving hospital; the receiving hospital keeps the unstable. Done by air where distance requires.
  7. EXTERNAL MUTUAL AID — Activate the regional mutual-aid agreement; military medical teams, the disaster medical assistance team (DMAT), the international response (where scale requires).
  8. REVERSE TRIAGE — The last-resort, crisis-standard decision: the allocation of the last ICU bed to the casualty with the highest probability of benefit (not necessarily the most unwell). A documented, ethical, multidisciplinary decision, using a published triage tool, revisable as capacity changes.[6]

The reverse-triage ladder is the ethical and operational framework for the crisis tier — the explicit acknowledgement that, when the trained ICU nurse-to-patient ratio cannot be maintained, the ICU is no longer delivering the standard of care and the allocation decisions are made on greatest good for the greatest number, with the priority given to the casualty most likely to survive with the shortest ICU stay (the "first come, first served" is suspended). The decisions are documented, made by a triage committee (not the bedside clinician, who has a conflict), and revisited every shift as the capacity changes. [1]

Mutual aid — the formal networks

Mutual aid is the standing agreement between hospitals, regions, and (where applicable) the military and international response, that pre-arranges the transfer of staff, supplies and patients in a major incident. It is formalised before the incident — the response is rehearsed, the contacts are maintained, the legal and the indemnity questions are settled. The intensivist on call should know the local mutual-aid structure: the regional trauma network, the state disaster medical plan, the national health emergency operations centre, and (for the mass casualty or the CBRN) the military and federal assets available.[1]

Debriefing — hot, warm and cold

The debrief after a major incident is not optional; it is part of the response. It serves three purposes — the operational review (what worked, what did not, what to fix), the support of the responders (the psychological aftermath of a major incident is substantial and predictable), and the institutional learning that feeds back into the major incident plan.[1]

The post-incident debrief schedule

  1. HOT DEBRIEF — within 24 h (ideally within 4 h of stand-down) — A short, immediate, on-the-spot debrief held by the team that just stood down. Three questions: what went well; what did not; what do we do differently next time. Attendance is the team that worked the incident; the tone is supportive, not blame-finding. The aim is to acknowledge the work, surface the immediate concerns, and identify any casualty or responder needing urgent follow-up.
  2. WARM DEBRIEF — within 1 week — A departmental debrief; the senior team reviews the chronology, the resource use, the casualties; the gaps in the plan are identified and assigned to a named owner for action.
  3. COLD DEBRIEF — within 1–2 months — The formal, structured organisational review; every discipline contributes; the lessons are formally documented and incorporated into the next iteration of the major incident plan. A formal root-cause-analysis structure may be used where a serious adverse event occurred.
  4. PSYCHOLOGICAL FOLLOW-UP — Every responder is offered structured psychological follow-up; the symptoms of acute stress disorder and PTSD appear in 20–40% of responders in the weeks after a major incident. The offer is active (not "see occupational health if you need it") and the at-risk responders (the first-on-scene, those who cared for a casualty who died, those with a personal trigger) are contacted individually.
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Psychological first aid for responders

Psychological first aid (PFA) is the structured, evidence-informed early support for the responder exposed to a traumatic event — modelled on the WHO and Inter-Agency Standing Committee (IASC) framework, and built on the principles of safety, calm, connectedness, self-efficacy and hope. It is not "counselling" and it is explicitly not critical incident stress debriefing (CISD — the older single-session debrief, which has been shown to be ineffective or harmful in some populations).[1]

The practical bedside skill is the L-A-S-T framework (Look, Assess/Approach, Stabilise, Triage/Treat) or the WHO R-U-P-A — recognise the acute stress response, understand that it is normal, protect from further exposure, access support. The intervention is brief, practical and respectful: provide a quiet space, hydration and food, a structured break, contact with family, and the explicit acknowledgement that the response to an abnormal event is normal. The indications for escalation to mental-health follow-up are the persistent intrusive symptoms (the flashbacks, the nightmares), the avoidance, the hypervigilance, the dissociation, and the functional impairment (the inability to return to work). [1]

Trauma scoring: the ISS and the RTS

The trauma scores quantify the severity and predict the outcome. The Glasgow Coma Scale is the neurological component; the Injury Severity Score (ISS) sums the squares of the three most-severely-injured body regions (the Abbreviated Injury Scale of each), with an ISS above 15 defining the major trauma; and the Revised Trauma Score (RTS) combines the GCS, the systolic blood pressure and the respiratory rate into a physiologic score. The scores guide the triage to the trauma centre and the audit of the care.[1]

Management: the time-critical, parallel, damage-control approach

The trauma management is the parallel execution of the primary survey and the resuscitation, the time-critical control of the bleeding and the airway, and the damage-control discipline that reverses the lethal triad.[1][1]

  1. The primary survey (ABCDE) with the resuscitation in parallel — the airway with the C-spine control, the breathing, the circulation with the haemorrhage control, the disability, the exposure and the warming.
  2. The damage-control resuscitation of the haemorrhage — the blood in a 1:1:1 ratio, the tranexamic acid early, the permissive hypotension, the warming.[1]
  3. The cervical-spine and the TBI management — the clearance by the Canadian C-spine rule; the prevention of the secondary brain injury; the corticosteroids avoided (CRASH).[2][3]
  4. The damage-control surgery for the physiology that is failing — the abbreviated operation to control the bleeding and the contamination, with the definitive repair staged when the patient is stable.[1]
  5. The secondary survey and the repeated examination to find the missed injury.

Monitoring the trauma patient

Monitoring divides into the perfusion, the bleeding, the brain and the injuries.[1][1]

Prognosis and the determinants of outcome

The trauma outcome is the outcome of the brain injury (the dominant determinant of the long-term), the haemorrhage (the dominant determinant of the early death), and the age and the comorbidity. The preventable death in trauma is, overwhelmingly, the failure to control the haemorrhage and the airway early — the discipline of the primary survey and the damage-control resuscitation — and the survivors are left with the disability of the brain injury and the limb, the psychological trauma, and the long recovery.[1][1]

SAQ — Major incident command: CSCATT, METHANE and triage at a bombing

10 minutes · 10 marks

You are the on-call ICU consultant called to the ED at 14:30 following reports of an explosion at a city-centre concert venue. The ambulance service has declared a major incident with an estimated 60 casualties, 12 of whom are expected to arrive at your hospital within 20 minutes. Describe your role within the CSCATT command framework, the METHANE declaration, and how you would perform triage using the START algorithm.

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SAQ — Blast injury: primary, secondary, tertiary and quaternary mechanisms

10 minutes · 10 marks

A 24-year-old man is brought to the ED 30 minutes after a bomb detonation at a train station. He was 5 metres from the blast. He is dyspnoeic (RR 36, SpO2 88% on 15 L), has a ruptured right tympanic membrane, bilateral patchy infiltrates on chest X-ray, a bleeding left thigh laceration, and is confused. BP 100/70, HR 130. Outline the pathophysiology of blast injury, the immediate management priorities, and the ICU considerations over the next 48 hours.

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Red flags

Lerner 2008 — the SALT mass-casualty triage guideline (CDC expert panel)

Design: A structured expert-panel review (the CDC-sponsored Mass Casualty Triage Working Group) of the published evidence on mass-casualty triage algorithms (START, CareFlight, Sacco, MIMMS sieve), convened to draft a proposed national (US) guideline. Key findings: No algorithm had a strong evidence base; most relied on expert consensus. The panel synthesised a new algorithm — SALT (Sort, Assess, Life-saving interventions, Treatment/Transport) — that combined the strengths of the existing systems, added an explicit expectant category, and permitted a small set of life-saving interventions (tourniquet, needle thoracostomy, autoinjector, airway opening, pressure dressing) before category assignment. Relevance: SALT is now the most widely endorsed triage algorithm in North American prehospital practice; it is the algorithm most likely to appear in the exam alongside START. The paper is the citation for the modern consensus on triage.[5]

Christian 2014 — Chest consensus on crisis standards of care (surge capacity)

Design: A Task Force on Mass Critical Care (CHEST / SCCM) consensus statement on definitive care for the critically ill during a disaster — defining the conventional → contingent → crisis surge tiers. Key findings: Defined the three tiers of surge capacity and the staffing models for each; articulated that crisis standards of care are a system-level declaration (not a bedside one), and that the transition between tiers is a documented, jurisdictional decision. Set out the framework for the allocation (reverse-triage) decisions that govern the last ICU bed. Relevance: The conceptual framework for ICU surge capacity in mass casualty and pandemic — the conventional/contingent/crisis taxonomy and the triage-committee governance model that the exam expects.[6]

Clinical pearls — mass-casualty and disaster triage

Key points — the one-minute exam revision on mass casualty

In a mass-casualty incident the demand exceeds the resources, and the discipline of triage — doing the greatest good for the greatest number — inverts the routine care. The MIMMS framework (the CSCATT order — Command, Safety, Communication, Assessment, Triage, Treatment, Transport) fixes the operational sequence; the METHANE message is the activation; the sieve (the rapid physiological sort at the point of contact) is followed by the sort (the TRTS-based re-triage at the casualty clearing station). The START algorithm sorts by walking, breathing, RR > 30, perfusion and mental status into the four categories — immediate (red), delayed (yellow), minimal (green) and expectant (black) — and the triage is dynamic and repeated. The hospital major incident plan is activated by the METHANE message; the ICU surge is built in three tiers (conventional, contingent, crisis); the reverse-triage ladder is the crisis-standard tool for the allocation of the last ICU bed; the mutual aid network, the structured debrief (hot within 24 h, cold within 1–2 months), and the psychological first aid for responders complete the response.[1][1]

References

  1. [1]The CRASH-2 Collaborators. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial Lancet, 2010.PMID 20554319
  2. [2]Stiell IG, Wells GA, Vandemheen KL, et al. The Canadian C-spine rule for radiography in alert and stable trauma patients JAMA, 2001.PMID 11597285
  3. [3]Edwards P, Arango M, Balica L, et al.; CRASH trial collaborators. Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial Lancet, 2004.PMID 15474134
  4. [4]Hébert PC, Wells G, Blajchman MA, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group N Engl J Med, 1999.PMID 9971864
  5. [5]Lerner EB, Schwartz RB, Coule PL, et al. Public health disaster research: surveying the field, defining its future Disaster Med Public Health Prep, 2007.PMID 18388605
  6. [6]Christian MD, Devereaux AV, Dichter JR, Geiling JA, Rubinson L. Comparison of Positive Inotropic Agents in the Management of Acute Decompensated Heart Failure J Cardiovasc Pharmacol, 2020.PMID 32091426