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Paeds SAQsneurology-neurodisability-and-neuromuscular

Paeds SAQs · neurology-neurodisability-and-neuromuscular

Non-epileptic events and functional seizures — formative SAQs

Two formative SAQs on non-epileptic events and functional seizures: a fourteen-year-old referred for spells unresponsive to two escalating antiseizure drugs, testing the recognition and video-electroencephalogram confirmation of a functional seizure and the correct pathway of explanation, drug withdrawal and cognitive behavioural therapy; and a sixteen-year-old brought to the emergency department in a prolonged flurry of attacks, testing the safe management of status non-epilepticus and the safeguarding history that the presentation demands.

20 marks30 min
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Target exams

RACP General PaediatricsRACP DWEMRCPCH TheoryABP General Pediatrics

Target exams

RACP General PaediatricsRACP DWEMRCPCH TheoryABP General Pediatrics
Prompt
Non-epileptic events and functional seizures

SAQ 1 — Fourteen-year-old with treatment-resistant spells (10 marks, 15 minutes)

A fourteen-year-old girl is referred to the epilepsy service for spells that began a year ago and occur several times a week. Each lasts five to ten minutes: she slumps, her eyes are closed and she resists them being opened, her limbs move in a variable thrashing pattern, she occasionally groans, and within a minute of the event ending she is tearful but fully oriented. She has been started on two escalating antiseizure medications without any change in the events. Her parents separated six months ago, and her mother has a history of depression. [2]

a) What is the most likely diagnosis, and which four features of the events support it over epilepsy? Explain why the antiseizure drugs have not worked. (4 marks) [1] [2]

b) Describe the investigation that confirms the diagnosis, how it is performed, and what it must demonstrate. State why a normal interictal electroencephalogram alone is not sufficient. (3 marks) [1] [8]

c) Outline the stepwise management, including the conversation you would have with the girl and her family about the nature of the events, the role of the antiseizure drugs, and the pathway to recovery. (3 marks) [3] [10]

SAQ 2 — Sixteen-year-old in a prolonged flurry in the emergency department (10 marks, 15 minutes)

A sixteen-year-old boy is brought to the emergency department after a series of attacks that began two hours ago and have not stopped. He thrashes with his eyes closed for several minutes at a time, resists examination, and is fully oriented and tearful between attacks. The triage nurse asks whether this is status epilepticus and whether he needs a benzodiazepine and an intensive-care review. He has a long-standing epilepsy and takes an antiseizure drug. [5]

a) What is the most likely diagnosis, and how do you distinguish this prolonged functional flurry from convulsive status epilepticus at the bedside? (4 marks) [1] [5]

b) Outline your immediate management of the episode, and explain why escalating benzodiazepines and anaesthesia are inappropriate and potentially harmful. (3 marks) [5] [7]

c) He has known epilepsy and continues his antiseizure drug. Explain how you would manage the coexistence of the two conditions, and describe the psychosocial and safeguarding assessment you would undertake once the episode has settled. (3 marks) [12] [2]

References

  1. [1]Leibetseder A; Eisermann M; LaFrance WC Jr; et al How to distinguish seizures from non-epileptic manifestations Epileptic Disord, 2020.PMID 33399092
  2. [2]Doss JL; Robinson JO; et al Psychogenic non-epileptic seizures in youth: Individual and family psychiatric characteristics Front Psychiatry, 2022.PMID 36590633
  3. [3]Gasparini S; Beghi E; Ferlazzo E; et al Management of psychogenic non-epileptic seizures: a multidisciplinary approach Eur J Neurol, 2019.PMID 30300463
  4. [4]Espay AJ; Aybek S; Carson A; et al Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders JAMA Neurol, 2018.PMID 29868890
  5. [5]Lopez MR; LaFrance WC Jr Treatment of Psychogenic Nonepileptic Seizures Curr Neurol Neurosci Rep, 2022.PMID 35674871
  6. [6]Hallett M; Aybek S; Dworetzky BA; et al Functional neurological disorder: new subtypes and shared mechanisms Lancet Neurol, 2022.PMID 35430029
  7. [7]Patel H; Blake H; Dunn D Psychogenic Nonepileptic Seizures in Children and Adolescents Indian Pediatr, 2021.PMID 33713062
  8. [8]Albert DVF; Voeller K; et al Psychogenic Nonepileptic Seizures in Children and Adolescents Semin Pediatr Neurol, 2022.PMID 35450667
  9. [9]LaFrance WC Jr; Baird GL; Barry JJ; et al Multicenter pilot treatment trial for psychogenic nonepileptic seizures: a randomized clinical trial JAMA Psychiatry, 2014.PMID 24989152
  10. [10]Goldstein LH; Robinson EJ; Mellers JDC; et al Cognitive behavioural therapy for adults with dissociative seizures (CODES): a pragmatic, multicentre, randomised controlled trial Lancet Psychiatry, 2020.PMID 32445688
  11. [11]Spiegel D; Lewis-Fernandez R; Lanius R; et al Dissociative disorders in DSM-5 Annu Rev Clin Psychol, 2013.PMID 23394228
  12. [12]Hamed SA; Attiah FA; Fawzy M Psychogenic nonepileptic seizures in adults with epilepsy: a tertiary hospital-based study Int J Neurosci, 2020.PMID 31771384