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Folio edition · Set in Instrument Serif & Archivo

Paeds Vivasneurology-neurodisability-and-neuromuscular

Paeds Vivas · neurology-neurodisability-and-neuromuscular

Non-epileptic events and functional seizures — branching viva

Branching viva across three young people with non-epileptic events: a thirteen-year-old whose bizarre brief nocturnal attacks could be functional or frontal-lobe epilepsy, testing the diagnostic trap and the place of video-electroencephalogram; a fifteen-year-old with treatment-resistant spells on two antiseizure drugs, testing the positive diagnosis and the pathway of explanation, drug withdrawal and cognitive behavioural therapy; and a sixteen-year-old in a prolonged emergency-department flurry, testing the safe management of status non-epilepticus and the safeguarding history.

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Target exams

RACP General PaediatricsRACP DCEMRCPCH ClinicalRCPSC Pediatrics

Target exams

RACP General PaediatricsRACP DCEMRCPCH ClinicalRCPSC Pediatrics
Prompt
You are the paediatric neurology registrar in the epilepsy service. The examiner asks you to assess three young people in sequence: a thirteen-year-old with bizarre brief nocturnal attacks; a fifteen-year-old with daily spells unresponsive to two antiseizure drugs; and a sixteen-year-old in a prolonged flurry in the emergency department. The examiner releases information in stages and will press you on your diagnosis, your investigation, and your thresholds for treatment and for withholding it.

Stem 1 — Thirteen-year-old with bizarre brief nocturnal attacks (5 minutes)

A thirteen-year-old boy is referred for nocturnal attacks in which he suddenly sits up, thrashes his limbs for thirty to sixty seconds with his eyes open, and then returns to sleep. The events cluster, occurring several times a night, and began after he started a new school. His interictal electroencephalogram is normal. [1]

Branch A (examiner): What are the two leading diagnoses, and which semiological features would you use to separate a functional event from frontal-lobe epilepsy? [1]

Branch B (examiner): The examiner points out that frontal-lobe epilepsy can show a normal scalp electroencephalogram. How do you resolve this, and what further investigation would you arrange? [8]

Branch C (examiner): The attacks are captured on video-electroencephalogram and the ictal recording is normal. Explain how you would deliver the diagnosis and outline the management. [3] [10]

Stem 2 — Fifteen-year-old with daily treatment-resistant spells (5 minutes)

A fifteen-year-old girl has daily spells lasting five to ten minutes with her eyes closed and resisting, a variable thrashing pattern, and rapid full recovery. She is on two escalating antiseizure medications without change in the events. Her parents separated recently and her mother has depression. [2]

Branch A (examiner): What is the most likely diagnosis, and which four features support it over epilepsy? Why have the antiseizure drugs failed? [1] [2]

Branch B (examiner): Describe the investigation that confirms the diagnosis and what it must show. Why is a normal interictal electroencephalogram not enough, and what is the place of prolactin? [1] [8]

Branch C (examiner): Outline the stepwise management, including how you withdraw the antiseizure drugs, the psychological therapy you offer, and the conversation you lead with the girl and her family. [5] [10]

Stem 3 — Sixteen-year-old in a prolonged emergency-department flurry (5 minutes)

A sixteen-year-old boy with known epilepsy arrives in the emergency department after two hours of recurrent attacks. He thrashes with his eyes closed, resists examination, and is tearful and oriented between attacks. The team asks whether this is status epilepticus and whether to give a benzodiazepine and call intensive care. [5]

Branch A (examiner): What is the most likely diagnosis, and how do you distinguish this prolonged functional flurry from convulsive status epilepticus at the bedside? [1] [5]

Branch B (examiner): Outline your immediate management and explain why escalating benzodiazepines and anaesthesia are inappropriate and potentially harmful. [5] [7]

Branch C (examiner): He continues his antiseizure drug for his epilepsy. Explain how you manage the coexistence of the two conditions, and describe the psychosocial and safeguarding assessment you undertake once the episode settles. [12] [2]

References

  1. [1]Leibetseder A; Eisermann M; LaFrance WC Jr; et al How to distinguish seizures from non-epileptic manifestations Epileptic Disord, 2020.PMID 33399092
  2. [2]Doss JL; Robinson JO; et al Psychogenic non-epileptic seizures in youth: Individual and family psychiatric characteristics Front Psychiatry, 2022.PMID 36590633
  3. [3]Gasparini S; Beghi E; Ferlazzo E; et al Management of psychogenic non-epileptic seizures: a multidisciplinary approach Eur J Neurol, 2019.PMID 30300463
  4. [4]Espay AJ; Aybek S; Carson A; et al Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders JAMA Neurol, 2018.PMID 29868890
  5. [5]Lopez MR; LaFrance WC Jr Treatment of Psychogenic Nonepileptic Seizures Curr Neurol Neurosci Rep, 2022.PMID 35674871
  6. [6]Hallett M; Aybek S; Dworetzky BA; et al Functional neurological disorder: new subtypes and shared mechanisms Lancet Neurol, 2022.PMID 35430029
  7. [7]Patel H; Blake H; Dunn D Psychogenic Nonepileptic Seizures in Children and Adolescents Indian Pediatr, 2021.PMID 33713062
  8. [8]Albert DVF; Voeller K; et al Psychogenic Nonepileptic Seizures in Children and Adolescents Semin Pediatr Neurol, 2022.PMID 35450667
  9. [9]LaFrance WC Jr; Baird GL; Barry JJ; et al Multicenter pilot treatment trial for psychogenic nonepileptic seizures: a randomized clinical trial JAMA Psychiatry, 2014.PMID 24989152
  10. [10]Goldstein LH; Robinson EJ; Mellers JDC; et al Cognitive behavioural therapy for adults with dissociative seizures (CODES): a pragmatic, multicentre, randomised controlled trial Lancet Psychiatry, 2020.PMID 32445688
  11. [11]Spiegel D; Lewis-Fernandez R; Lanius R; et al Dissociative disorders in DSM-5 Annu Rev Clin Psychol, 2013.PMID 23394228
  12. [12]Hamed SA; Attiah FA; Fawzy M Psychogenic nonepileptic seizures in adults with epilepsy: a tertiary hospital-based study Int J Neurosci, 2020.PMID 31771384