Phys Clinical Cases · rheumatological
Antiphospholipid Syndrome — DCE Clinical Case
DCE long-case and short-case station for Antiphospholipid Syndrome.
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Antiphospholipid Syndrome — Clinical Case
DCE Long Case
Patient brief
Patient: A middle-aged or older adult with multimorbidity and a presentation centred on Antiphospholipid Syndrome. [1]
Presenting complaint: Subacute or acute symptoms referable to Antiphospholipid Syndrome, with enough detail to force prioritisation. [1] [2]
Past history: Common cardiometabolic and organ comorbidities that interact with the plan. [2]
Medications: A polypharmacy list that includes at least one interaction or dosing issue. [2]
Examination: Key positives and critical negatives for dangerous differentials. [1]
Investigations: A small set of results that change management. [1] [2]
Tasks
- Present a prioritised problem list. [1]
- Defend investigations and immediate therapy. [1] [2]
- Provide safety-net and follow-up advice. [2]
Model discussion points
- Working diagnosis and acuity. [1]
- Differentials and discriminators. [2]
- Treatment sequence and monitoring. [1] [2] [3]
- Multimorbidity and communication. [2]
Short case
Focused examination or counselling station linked to Antiphospholipid Syndrome, with one interpretation task and one shared-decision point. [1] [2]
References
- [1]Vrotniakaite-Bajerciene K, Wang TF, Sabri E, Shorr R, et al. Recurrent VTE in patients with thrombophilia after stopping anticoagulation - A systematic review and meta-analysis Blood Adv, 2026.PMID 42448302
- [2]Fang HS, Zhang XY, Liu XY, Chen HD, et al. Chromogenic factor X-guided warfarin monitoring in lupus anticoagulant-positive primary antiphospholipid syndrome with adrenal hemorrhage and progressive deep vein thrombosis: a case report J Med Case Rep, 2026.PMID 42437947
- [3]Mohammadi A, Fattahi V Anesthesia in systemic lupus erythematosus: a review of key considerations and surgical challenges Perioper Med (Lond), 2026.PMID 42421133
- [4]Esteban-Sampedro J, Martín-Portugués M, Ruiz-Irastorza G, Mellor-Pita S, et al. Impact of systemic autoimmune diseases in maternal, fetal and neonatal outcomes in Spain Rheumatology (Oxford), 2026.PMID 42421209
- [5]Hidaka A, Kaneshige R, Nakamura S, Motoki Y, et al. Preliminary Evaluation of a Novel Lupus Anticoagulant Activity Assay Unaffected by Anticoagulants J Clin Lab Anal, 2026.PMID 42310902
- [6]Ordieres-Ortega L, Galeano-Valle F, López-Rubio M, Alonso-Beato R, et al. Recurrent VTE During Anticoagulation: Diagnosis, Systematic Evaluation, and Management Chest, 2026.PMID 42264028
- [7]Xi Y, Yao T, Zhang C, Zhuang T Effectiveness of safety care and clinical nursing pathway in patients undergoing cardiovascular intervention: a randomized controlled trial Perioper Med (Lond), 2026.PMID 42469924
- [8]Marks FJ, Walters SJ, Sutton L, Jacques RM What statistical methods are more appropriate for predicting recruitment at the design stage of a randomised controlled trial? Trials, 2026.PMID 42469922