Phys Clinical Cases · dermatological
Genodermatoses with Systemic Significance — DCE Clinical Case
DCE long-case and short-case station for Genodermatoses with Systemic Significance.
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Genodermatoses with Systemic Significance — Clinical Case
DCE Long Case
Patient brief
Patient: A middle-aged or older adult with multimorbidity and a presentation centred on Genodermatoses with Systemic Significance. [1]
Presenting complaint: Subacute or acute symptoms referable to Genodermatoses with Systemic Significance, with enough detail to force prioritisation. [1] [2]
Past history: Common cardiometabolic and organ comorbidities that interact with the plan. [2]
Medications: A polypharmacy list that includes at least one interaction or dosing issue. [2]
Examination: Key positives and critical negatives for dangerous differentials. [1]
Investigations: A small set of results that change management. [1] [2]
Tasks
- Present a prioritised problem list. [1]
- Defend investigations and immediate therapy. [1] [2]
- Provide safety-net and follow-up advice. [2]
Model discussion points
- Working diagnosis and acuity. [1]
- Differentials and discriminators. [2]
- Treatment sequence and monitoring. [1] [2] [3]
- Multimorbidity and communication. [2]
Short case
Focused examination or counselling station linked to Genodermatoses with Systemic Significance, with one interpretation task and one shared-decision point. [1] [2]
References
- [1]Wagner RN, Piñón Hofbauer J, Wally V, Kofler B, et al. Epigenetic and metabolic regulation of epidermal homeostasis Exp Dermatol, 2021.PMID 33600038
- [2]Youssefian L, Vahidnezhad H, Touati A, Ziaee V, et al. The genetic basis of hyaline fibromatosis syndrome in patients from a consanguineous background: a case series BMC Med Genet, 2018.PMID 29801470
- [3]Xi Y, Yao T, Zhang C, Zhuang T Effectiveness of safety care and clinical nursing pathway in patients undergoing cardiovascular intervention: a randomized controlled trial Perioper Med (Lond), 2026.PMID 42469924
- [4]Marks FJ, Walters SJ, Sutton L, Jacques RM What statistical methods are more appropriate for predicting recruitment at the design stage of a randomised controlled trial? Trials, 2026.PMID 42469922
- [5]Hajiaqaei M, Mohammadi A Transcranial random noise stimulation (tRNS) over the left dorsolateral prefrontal cortex ameliorates emotion dysregulation and executive function: a single-blind, randomized, sham-controlled clinical trial BMC Psychol, 2026.PMID 42469906
- [6]Aw Hashi MO, Derie AM, Ahmed SI Lamellar Ichthyosis in a Resource-Limited Setting: A Somaliland Case Report Int Med Case Rep J, 2026.PMID 41940243
- [7]Boitez P, Farges D, Descamps M, Bournazel V, et al. The first year of treatment with selumetinib for NF1-related plexiform neurofibroma is medically challenging in real-life settings Ann Dermatol Venereol, 2026.PMID 41411884
- [8]Rossignol J, Bouillet L, Bulai-Livideanu C, Barete S, et al. Diagnosis, management and the burden of symptoms of mastocytosis from the physician's perspective: A nationwide study Br J Haematol, 2025.PMID 40930805