Phys Clinical Cases · haematological
Myelodysplastic Syndromes — DCE Clinical Case
DCE long-case and short-case station for Myelodysplastic Syndromes.
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Myelodysplastic Syndromes — Clinical Case
DCE Long Case
Patient brief
Patient: A middle-aged or older adult with multimorbidity and a presentation centred on Myelodysplastic Syndromes. [1]
Presenting complaint: Subacute or acute symptoms referable to Myelodysplastic Syndromes, with enough detail to force prioritisation. [1] [2]
Past history: Common cardiometabolic and organ comorbidities that interact with the plan. [2]
Medications: A polypharmacy list that includes at least one interaction or dosing issue. [2]
Examination: Key positives and critical negatives for dangerous differentials. [1]
Investigations: A small set of results that change management. [1] [2]
Tasks
- Present a prioritised problem list. [1]
- Defend investigations and immediate therapy. [1] [2]
- Provide safety-net and follow-up advice. [2]
Model discussion points
- Working diagnosis and acuity. [1]
- Differentials and discriminators. [2]
- Treatment sequence and monitoring. [1] [2] [3]
- Multimorbidity and communication. [2]
Short case
Focused examination or counselling station linked to Myelodysplastic Syndromes, with one interpretation task and one shared-decision point. [1] [2]
References
- [1]Nabergoj M, Bou Mjahed R, Basset V, Tsilimidos G, et al. Monocytose réactionnelle versus clonale : la leucémie myélomonocytaire chronique Rev Med Suisse, 2026.PMID 42464748
- [2]Liapis K, Papadopoulos V, Stamatiou I, Koparanis D, et al. Excess risk for cardiovascular and noncardiovascular comorbidities and multimorbidity among patients with myelodysplastic syndrome: A systematic review and meta-analysis Cancer, 2026.PMID 42464613
- [3]An W, Guo S, Wang H, Lv T, et al. The role and therapeutic potential of nanotechnology-mediated ferroptosis regulation in myelodysplastic syndromes Front Oncol, 2026.PMID 42459301
- [4]Abdulgayoom M, Gulied A, Alshurafa A, Mohamed SF, et al. Venetoclax-Integrated Conditioning Strategies Prior to Allogeneic Hematopoietic Stem Cell Transplantation in Myeloid Neoplasms: A Scoping Review of Emerging Evidence Eur J Haematol, 2026.PMID 41917774
- [5]Carraway HE, DeAngelo DJ, Wang ES, Komrokji RS, et al. Clinical strategies for leukemia management: Recommendations from the Bridging the Gaps in Hematology Oncology Consensus Conference 2025 Leuk Res, 2026.PMID 41895012
- [6]Zhang L, Ying S, Fang F, Li Q, et al. Prognostic impact of myelodysplasia-related gene mutations in ELN-2022 favorable-risk acute myeloid leukemia subtypes Ann Med, 2026.PMID 41797681
- [7]Xi Y, Yao T, Zhang C, Zhuang T Effectiveness of safety care and clinical nursing pathway in patients undergoing cardiovascular intervention: a randomized controlled trial Perioper Med (Lond), 2026.PMID 42469924
- [8]Marks FJ, Walters SJ, Sutton L, Jacques RM What statistical methods are more appropriate for predicting recruitment at the design stage of a randomised controlled trial? Trials, 2026.PMID 42469922