Phys Clinical Cases · pharmacological
Therapeutic Drug Monitoring — DCE Clinical Case
DCE long-case and short-case station for Therapeutic Drug Monitoring.
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Therapeutic Drug Monitoring — Clinical Case
DCE Long Case
Patient brief
Patient: A middle-aged or older adult with multimorbidity and a presentation centred on Therapeutic Drug Monitoring. [1]
Presenting complaint: Subacute or acute symptoms referable to Therapeutic Drug Monitoring, with enough detail to force prioritisation. [1] [2]
Past history: Common cardiometabolic and organ comorbidities that interact with the plan. [2]
Medications: A polypharmacy list that includes at least one interaction or dosing issue. [2]
Examination: Key positives and critical negatives for dangerous differentials. [1]
Investigations: A small set of results that change management. [1] [2]
Tasks
- Present a prioritised problem list. [1]
- Defend investigations and immediate therapy. [1] [2]
- Provide safety-net and follow-up advice. [2]
Model discussion points
- Working diagnosis and acuity. [1]
- Differentials and discriminators. [2]
- Treatment sequence and monitoring. [1] [2] [3]
- Multimorbidity and communication. [2]
Short case
Focused examination or counselling station linked to Therapeutic Drug Monitoring, with one interpretation task and one shared-decision point. [1] [2]
References
- [1]DiStefano MJ, Tilley A, Paratane D, Gyimah Gyamfi H, et al. Postshortage Compounded GLP-1 RA Market in 2 States With Potentially High Demand JAMA Health Forum, 2026.PMID 42467450
- [2]Ullah A Baxdrostat and selective aldosterone synthase inhibition in hard-to-control hypertension: mechanism, evidence, safety, and future clinical positioning Expert Opin Pharmacother, 2026.PMID 42467440
- [3]Kim JE, Noh JY, Lee KE, Lee YI, et al. Non-Cytopathic Mammalian Orthoreovirus Infection Triggers Innate Immune Responses in Human Tonsil-Derived Mesenchymal Stem Cells: Implications for Cell Therapy Quality Control Tissue Eng Regen Med, 2026.PMID 42467368
- [4]Deressa JD, Behaksra SW, Molla E, Letebo A, et al. Therapeutic efficacy of artemether-lumefantrine plus single low dose primaquine for the treatment of uncomplicated Plasmodium falciparum malaria in a high transmission setting, Western Ethiopia PLoS One, 2026.PMID 42467750
- [5]Morales Junior R, Telles JP, Chua NGS, Kunicki PK, et al. Mapping Therapeutic Drug Monitoring Research in Low- and Middle-Income Countries: A Scoping Review (2015-2024) Ther Drug Monit, 2026.PMID 42457203
- [6]McGarity MZ, Pollack CC, Currier EA, Godoshian AC, et al. Characteristics Influencing Adherence to SARS-CoV-2 Serial Antigen Testing Following a Federal Safety Communication: Cohort Study JMIR Public Health Surveill, 2026.PMID 42456150
- [7]Doan HN, Chang MC Comparative Effectiveness of Unstable Versus Stable Resistance Training on Lower Limb Strength, Mobility, and Fear of Falling in Older Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials Am J Phys Med Rehabil, 2026.PMID 42468010
- [8]Liu HW, Tsai TL Virtual Reality-assisted Physiotherapeutic Training for Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis Am J Phys Med Rehabil, 2026.PMID 42468005