Phys Vivas · rheumatological
Complement Deficiencies AND Recurrent Infections — Viva Defence
DCE viva defence for Complement Deficiencies AND Recurrent Infections.
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Target exams
Complement Deficiencies AND Recurrent Infections Viva
Long Case Viva Defence
Opening statement
"This patient presents with a problem best framed as Complement Deficiencies AND Recurrent Infections. My priorities are to identify red flags, confirm the mechanism with purposeful investigations, start a sequenced management plan, and integrate multimorbidity and follow-up." [1] [2]
Examiner questions
Q1: "What makes this urgent?" [1]
"I look for threats to airway, perfusion, neurology, metabolism, infection or bleeding, and I escalate those before elective work-up." [1] [2]
Q2: "What is your first investigation package?" [2]
"I order tests that change management now, not a scattergun panel." [1] [2]
Q3: "Walk me through treatment." [1]
"Stabilise, treat the mechanism, prevent complications, and plan monitoring." [1] [2] [3]
Q4: "What is the classic trap?" [2]
"Treating a label without confirming the discriminating mechanism, or delaying escalation." [1] [2]
Short case
Counsel the patient on the plan, risks and warning symptoms in plain language. [1] [2]
References
- [1]Mottaghipisheh H, Jahromi AM, Mirzaei F, Meri S, et al. Homozygous C1qA Deficiency Presenting as Early-Onset Systemic Lupus Erythematosus: A Case Report With a Literature Review Case Reports Immunol, 2026.PMID 42147803
- [2]Consolini R, Maestrini G, Abu-Rumeileh S, Costagliola G The Intertwining Between Arthritis and Inborn Errors of Immunity J Clin Med, 2026.PMID 42123030
- [3]Boccon-Gibod I, Fain O, Gobert D, Debord S, et al. French protocol for the diagnosis and management of hereditary angioedema Rev Med Interne, 2025.PMID 41168057
- [4]Schejbel L, Fadnes D, Permin H, Lappegård KT, et al. Primary complement C5 deficiencies - molecular characterization and clinical review of two families Immunobiology, 2013.PMID 23743184
- [5]Xi Y, Yao T, Zhang C, Zhuang T Effectiveness of safety care and clinical nursing pathway in patients undergoing cardiovascular intervention: a randomized controlled trial Perioper Med (Lond), 2026.PMID 42469924
- [6]Marks FJ, Walters SJ, Sutton L, Jacques RM What statistical methods are more appropriate for predicting recruitment at the design stage of a randomised controlled trial? Trials, 2026.PMID 42469922
- [7]Hajiaqaei M, Mohammadi A Transcranial random noise stimulation (tRNS) over the left dorsolateral prefrontal cortex ameliorates emotion dysregulation and executive function: a single-blind, randomized, sham-controlled clinical trial BMC Psychol, 2026.PMID 42469906
- [8]Donadoni M, La Cava L, Bizzi E, Popescu Janu V, et al. Hereditary Angioedema Prophylaxis Therapy: Berotralstat and Lanadelumab Safety Profile Medicina (Kaunas), 2025.PMID 41303734