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Clinical Atlas Prestige · Evidence-first

Psych MEQs / SAQsGeneral adult psychiatry — psychotic disorders

Psych MEQs / SAQs · General adult psychiatry — psychotic disorders

Schizophreniform and brief psychotic disorder — duration, prognosis and FEP care (MEQ)

FRANZCP-style MEQ on schizophreniform vs brief psychosis duration, good prognostic features, organic/substance differentials, FEP-style treatment, and follow-up instability.

20 marks20 min
On this page & tools

Target exams

FRANZCPMRCPsychABPNMD-DNB

Target exams

FRANZCPMRCPsychABPNMD-DNB
Prompt
A 22-year-old university student is brought after 3 weeks of new third-person auditory hallucinations, persecutory delusions, and mild formal thought disorder. Premorbid function was excellent. Onset of frank psychosis was within 2 weeks of a sudden academic crisis. At interview he appears perplexed. Affect is not blunted. He used high-THC cannabis most weekends for 6 months but last used 10 days ago. Urine toxicology is now negative. No fever, normal observations, clear sensorium. (i) Give the best current DSM working diagnosis and justify duration thresholds. (ii) List good prognostic features present and state their clinical meaning. (iii) Outline acute assessment and investigation priorities. (iv) Propose a pharmacological and psychosocial plan with named agent, dose framework, and monitoring. (v) Explain diagnostic instability and post-remission maintenance counselling. (20 marks)

Model answer

Reveal model answer

(i) Working diagnosis. Schizophreniform disorder (provisional) — multi-domain Criterion A picture for about 3 weeks, already past the 1-month lower bound only if timing of first frank symptoms is confirmed at ≥1 month; if frank psychosis has truly lasted only 3 weeks, the cross-sectional label may still sit in the late brief psychotic / early schizophreniform border and must be dated carefully with collateral. Exam-safe line: if duration is ≥1 month and less than 6 months, schizophreniform is preferred over schizophrenia; if ≥1 day and less than 1 month with later full recovery, brief psychotic disorder. Do not diagnose schizophrenia at 3 weeks. Cannabis is a contributing risk factor, not automatically a pure substance-induced explanation after 10 days of documented abstinence with ongoing psychosis — revisit if timeline tightens.[1][6][7]

(ii) Good prognostic features present. (1) Onset of prominent psychosis within weeks of first change / acute crisis (within 4-week rule if first change aligns); (2) perplexity; (3) good premorbid function; (4) no blunted affect. Meaning: higher hope for recovery and possible specifier “with good prognostic features,” not a reason to withhold acute treatment.[1]

(iii) Acute assessment and investigations. Risk (suicide, violence, absconding), capacity, legal status under local statute, collateral for exact onset dates, substance timeline, sleep, mood screen for affective psychosis. Baseline: FBC, U&E/eGFR, LFT, glucose/HbA1c, lipids, ECG QTc, BMI/BP, pregnancy test if relevant; toxicology already done — interpret limits. Imaging/special tests if atypical features appear; none of fever/fluctuating attention here, but remain vigilant.[4]

(iv) Treatment plan. FEP-style package: engagement, early-intervention intensity, family psychoeducation, cannabis cessation support. Example oral start: aripiprazole 5–10 mg daily toward 10–15 mg, or risperidone 1–2 mg titrating carefully, with metabolic/EPS/akathisia monitoring — EUFEST supports pragmatic antipsychotic choice in first-episode schizophrenia and schizophreniform samples. CBTp access when engageable; sleep hygiene; safety net.[3][4][7]

(v) Instability and maintenance. Labels shift over years (schizophrenia, mood psychosis, or durable remission). After response, counsel that FEP discontinuation literature shows substantial recurrence risk if antipsychotics stop without a plan; any taper is individualised after consolidation, with early-warning signs and rapid re-access. Do not promise permanent cure from a short course.[2][5][6]

References

  1. [1]Naz B, Bromet EJ, Mojtabai R Distinguishing between first-admission schizophreniform disorder and schizophrenia Schizophr Res, 2003.PMID 12765743
  2. [2]Bromet EJ, Kotov R, Fochtmann LJ, et al. Diagnostic shifts during the decade following first admission for psychosis Am J Psychiatry, 2011.PMID 21676994
  3. [3]Kahn RS, Fleischhacker WW, Boter H, et al. Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial Lancet, 2008.PMID 18374841
  4. [4]Galletly C, Castle D, Dark F, et al. Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the management of schizophrenia and related disorders Aust N Z J Psychiatry, 2016.PMID 27106681
  5. [5]Zipursky RB, Menezes NM, Streiner DL Risk of symptom recurrence with medication discontinuation in first-episode psychosis: a systematic review Schizophr Res, 2014.PMID 23972821
  6. [6]Provenzani U, Salazar de Pablo G, Arribas M, et al. Clinical outcomes in brief psychotic episodes: a systematic review and meta-analysis Epidemiol Psychiatr Sci, 2021.PMID 35698876
  7. [7]Di Forti M, Quattrone D, Freeman TP, et al. The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI) Lancet Psychiatry, 2019.PMID 30902669