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Clinical Atlas Prestige · Evidence-first

Psych VivasOld age psychiatry — dementia neuropsychiatry

Psych Vivas · Old age psychiatry — dementia neuropsychiatry

BPSD — structured clinical viva

Fellowship viva on long-term antipsychotic use in BPSD, black-box harms, deprescribing, and non-drug care with landmark trial integration.

clinical
On this page & tools

Target exams

FRANZCPMRCPsychABPNMD-DNB

Target exams

FRANZCPMRCPsychABPNMD-DNB
Prompt
You are the psychiatry registrar. A GP and residential-care manager call about a 79-year-old man with Alzheimer disease on risperidone 1 mg twice daily for 9 months for 'aggression'. He is now sleepy, unsteady, and still occasionally resists showers. Family ask whether the tablet is 'keeping him alive calmly' or harming him. Discuss assessment of ongoing need, risks of continued antipsychotics, deprescribing strategy, non-drug alternatives, and how trial evidence (Schneider, CATIE-AD, DART-AD, Devanand) shapes your plan.

Interpretation

Reveal interpretation

This is chronic antipsychotic exposure for BPSD without clear ongoing severe risk, now with sedation and falls risk. Re-describe the original target symptom and current behaviour with ABC/DICE; exclude pain, constipation, infection and environmental triggers for residual shower resistance; screen for EPS, orthostasis and oversedation. Nine months without structured review is already a red flag. [1]

Evidence framing for family. Schneider meta-analysis: atypical antipsychotics increase death risk versus placebo in dementia RCTs. CATIE-AD: limited effectiveness and frequent discontinuation. DART-AD long-term: continued neuroleptics associated with higher mortality — the tablet is not a harmless "calm forever" medicine. Devanand: among responders, stopping risperidone can increase relapse — so taper carefully with monitoring rather than abrupt cessation if prior severe psychosis/aggression. [2][3][4][5]

Plan. Optimise non-drug personal-care strategies and pain management (Husebo). Gradual dose reduction (e.g. reduce by 25–50% every 1–2 weeks) toward stop if stable, with staff education on relapse signs and criteria to restart a low dose. Document risk–benefit discussion with substitute decision-maker. [1][6]

Key points

No open-ended antipsychotics

Every BPSD psychotropic needs a target symptom, review date and deprescribing intent.

Mortality is not theoretical

Schneider RCT meta-analysis and DART-AD long-term data make death risk central to consent.

Taper with a safety net

Devanand shows relapse can occur — monitor, do not abandon the patient after the last dose.
[2] [4] [5]

References

  1. [1]Kales HC, Gitlin LN, Lyketsos CG Assessment and management of behavioral and psychological symptoms of dementia BMJ, 2015.PMID 25731881
  2. [2]Schneider LS, Dagerman KS, Insel P Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials JAMA, 2005.PMID 16234500
  3. [3]Schneider LS, Tariot PN, Dagerman KS, et al. Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease N Engl J Med, 2006.PMID 17035647
  4. [4]Ballard C, Hanney ML, Theodoulou M, et al. The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomised placebo-controlled trial Lancet Neurol, 2009.PMID 19138567
  5. [5]Devanand DP, Mintzer J, Schultz SK, et al. Relapse risk after discontinuation of risperidone in Alzheimer's disease N Engl J Med, 2012.PMID 23075176
  6. [6]Husebo BS, Ballard C, Sandvik R, et al. Efficacy of treating pain to reduce behavioural disturbances in residents of nursing homes with dementia: cluster randomised clinical trial BMJ, 2011.PMID 21765198