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Folio edition · Set in Instrument Serif & Archivo

Psych VivasPsychotherapy — combined treatment

Psych Vivas · Psychotherapy — combined treatment

Combining psychotherapy and pharmacotherapy — structured clinical viva

Fellowship viva on concurrent vs sequential combination, Cuijpers/DeRubeis/Hollon/Guidi–Fava/Frank evidence, residual symptoms, and shared decision-making.

clinical
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Target exams

FRANZCPMRCPsychABPNMD-DNB

Target exams

FRANZCPMRCPsychABPNMD-DNB
Prompt
You are the psychiatry registrar. A 36-year-old woman with recurrent major depression (three lifetime episodes) has remitted on escitalopram 20 mg oral daily but still has residual anhedonia, avoidance of social contact, and fear of relapse. She asks whether combination treatment means she has 'failed' monotherapy, whether she should stop the SSRI now that she feels better, and whether CBT will 'clash' with tablets. Discuss models of combination, landmark evidence, sequential residual-symptom care, relapse prevention, and how you explain integrated care without ideology.

Interpretation

Reveal interpretation

Markers want a consultant-level account of combination as strategy (not failure, not dogma), sequential residual-symptom psychotherapy after pharmacologic response, durability of CT skills versus medication discontinuation risk, maintenance needs in recurrent depression, and plain-language explanation without anti-medication or anti-therapy ideology.[1][3][4]

Viva script

Q1. What is combined treatment?

Reveal model points

Structured psychotherapy plus psychotropic medication in one episode of care — concurrent, sequential, or collaborative/integrated packages. Not meds plus unstructured chat. Intent may be acute efficacy, residual symptoms, relapse prevention, or adherence support.[1][6]

Q2. Does combination mean monotherapy failed?

Reveal model points

No. Many patients benefit from either modality alone; combination is often additive, especially versus medication alone, and network evidence supports superiority of combination over monotherapies in adult depression. Partial response with residual symptoms is a reason to add therapy, not a personal failure.[1][6]

Q3. Acute parity and durability — DeRubeis/Hollon

Reveal model points

CT can match medications for initial treatment of moderate–severe MDD when competently delivered.[2] After response, discontinuing medication risks more relapse than after CT when active treatments stop — skills confer durability; this is not an instruction to stop her SSRI today without a plan.[3]

Q4. Sequential residual-symptom model for this woman

Reveal model points

She has remitted on escitalopram but residual anhedonia/avoidance and relapse fear. Guidi–Fava sequential model: after pharmacologic response, add psychotherapy targeting residual symptoms and well-being/relapse prevention rather than automatic polypharmacy.[4] Behavioural activation, cognitive relapse-prevention, and interpersonal work fit.

Q5. Should she stop the SSRI now?

Reveal model points

Not automatically. Recurrent depression (three episodes) often warrants maintenance pharmacotherapy for a substantial period; classic Frank maintenance data underscore full-dose maintenance antidepressant value in highly recurrent illness, with IPT maintenance intermediate.[5] Decision is shared: episode count, residual symptoms, prior relapse on stop, preference, pregnancy plans. If later taper is chosen, do it planned with booster therapy and early-warning signs — not abrupt stop because CBT begins.

Q6. Will CBT clash with tablets?

Reveal model points

No mechanistic prohibition. Tablets reduce intensity; therapy trains skills. Meta-analyses support adding psychotherapy to antidepressants.[1] Explain complementary roles; agree who manages side effects and crisis; keep measures shared.

Q7. Pitfalls to name

Reveal model points

False dichotomy; pseudo-CBT; stopping indicated meds for ideology; ignoring residual symptoms after scale “remission”; split care without communication; benzodiazepine safety behaviours in anxiety pathways (if relevant later).[1][4]

References

  1. [1]Cuijpers P, Sijbrandij M, Koole SL, et al. Adding psychotherapy to antidepressant medication in depression and anxiety disorders: a meta-analysis World Psychiatry, 2014.PMID 24497254
  2. [2]DeRubeis RJ, Hollon SD, Amsterdam JD, et al. Cognitive therapy vs medications in the treatment of moderate to severe depression Arch Gen Psychiatry, 2005.PMID 15809408
  3. [3]Hollon SD, DeRubeis RJ, Shelton RC, et al. Prevention of relapse following cognitive therapy vs medications in moderate to severe depression Arch Gen Psychiatry, 2005.PMID 15809409
  4. [4]Guidi J, Fava GA Sequential Combination of Pharmacotherapy and Psychotherapy in Major Depressive Disorder: A Systematic Review and Meta-analysis JAMA Psychiatry, 2021.PMID 33237285
  5. [5]Frank E, Kupfer DJ, Perel JM, et al. Three-year outcomes for maintenance therapies in recurrent depression Arch Gen Psychiatry, 1990.PMID 2244793
  6. [6]Cuijpers P, Noma H, Karyotaki E, et al. A network meta-analysis of the effects of psychotherapies, pharmacotherapies and their combination in the treatment of adult depression World Psychiatry, 2020.PMID 31922679