Psych Vivas · Psychopharmacology — ECT and neurostimulation
ECT and neurostimulation — consultant viva
Fellowship viva covering ECT efficacy evidence, placement/dosing, anaesthesia literacy, cognitive risks, continuation, TRS augmentation, and evidence-tiered rTMS/VNS/DBS.
On this page & tools
Target exams
Station structure
Time: 8–10 minutes. Depth: consultant teaching registrar. Expect named trials, placement physics without equations, legal humility (no invented sections), and clear device tiers.[1][7][8]
Core questions and model points
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What is ECT and why does it work clinically? Brief-pulse electrical induction of a generalised cerebral seizure under anaesthesia/muscle relaxation. Motor convulsion is a monitoring proxy (cuff technique). Mechanisms multi-pathway (neuroplastic, monoamine, anticonvulsant adaptation). Efficacy strongest for severe depression; also catatonia, mania, selected psychosis pathways.[8]
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Evidence elevator pitch? UK ECT Review Group: real greater than sham; bilateral moderately greater than unilateral; often greater than drugs short-term. CORE: rapid response; continuation strategies matter because relapse is common without a plan.[1][2]
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RUL vs BT — how do you choose? Cognition priority and less urgency → RUL/ultrabrief at high suprathreshold dose. Severity, urgency, RUL non-response → BT. Sackeim: placement and pulse width drive efficacy–cognition trade-off.[3][8]
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Cognitive adverse effects — how do you counsel? Post-ictal confusion; temporary anterograde impairment; variable retrograde autobiographical risk (most feared). Mitigate with placement/pulse width; never gaslight; balance against untreated illness risk.[3][10]
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Catatonia card. Examine with BFCRS structure; lorazepam trial; urgent ECT if malignant features or benzo failure. Do not delay for weeks of SSRI trials.[9][8]
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Clozapine-resistant schizophrenia. After optimised clozapine, ECT augmentation has randomised evidence (Petrides) — name it.[4]
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rTMS/iTBS card. Outpatient TRD option; sham-controlled trials; THREE-D iTBS non-inferior to 10 Hz with shorter sessions. Not a substitute for emergency ECT.[5]
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DBS card. Early open-label SCC hope; BROADEN failed primary endpoint — not routine care.[6]
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Governance. RANZCP ECT PPG (Weiss): consent, training, facilities, monitoring standards for ANZ. Capacity decision-specific; involuntary only under local law.[7]
Examiner probes (corners)
- "Why might seizure threshold rise during a course?" Anticonvulsant adaptation; dose may need increase; review benzos/anticonvulsants.[8]
- "She remitted after eight ECTs — are you done?" No — continuation pharmacotherapy and/or C-ECT plan.[2]
- "Family wants 'natural therapy only'." Acknowledge values; state mortality risk of untreated severe depression/catatonia; offer second opinion; legal pathway if capacity absent and risk extreme.[7][8]
Pass behaviours
Names trials accurately; places devices on evidence tiers; discusses memory without minimising; plans continuation; respects jurisdiction-specific law without fabricating statutes.[1][2][6][7]
References
- [1]UK ECT Review Group Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis Lancet, 2003.PMID 12642045
- [2]Kellner CH, Knapp RG, Petrides G, et al. Continuation electroconvulsive therapy vs pharmacotherapy for relapse prevention in major depression: CORE Arch Gen Psychiatry, 2006.PMID 17146008
- [3]Sackeim HA, Prudic J, Nobler MS, et al. Effects of pulse width and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy Brain Stimul, 2008.PMID 19756236
- [4]Petrides G, Malur C, Braga RJ, et al. Electroconvulsive therapy augmentation in clozapine-resistant schizophrenia: a prospective, randomized study Am J Psychiatry, 2015.PMID 25157964
- [5]Blumberger DM, Vila-Rodriguez F, Thorpe KE, et al. Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D) Lancet, 2018.PMID 29726344
- [6]Holtzheimer PE, Husain MM, Lisanby SH, et al. Subcallosal cingulate deep brain stimulation for treatment-resistant depression: BROADEN Lancet Psychiatry, 2017.PMID 28988904
- [7]Weiss A, Hussain S, Ng B, et al. RANZCP professional practice guidelines for the administration of electroconvulsive therapy Aust N Z J Psychiatry, 2019.PMID 30966782
- [8]Espinoza RT, Kellner CH Electroconvulsive Therapy N Engl J Med, 2022.PMID 35172057
- [9]Bush G, Fink M, Petrides G, et al. Catatonia. I. Rating scale and standardized examination Acta Psychiatr Scand, 1996.PMID 8686483
- [10]Sackeim HA, Prudic J, Fuller R, et al. The cognitive effects of electroconvulsive therapy in community settings Neuropsychopharmacology, 2007.PMID 16936712