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Clinical Atlas Prestige · Evidence-first

Psych VivasGeneral adult psychiatry — secondary / organic psychosis

Psych Vivas · General adult psychiatry — secondary / organic psychosis

Psychotic disorder due to another medical condition — structured clinical viva

Fellowship viva on secondary psychosis: cause groups, red flags, investigation ladder, AE hand-off, cautious antipsychotics, capacity/legal principles.

clinical
On this page & tools

Target exams

FRANZCPMRCPsychABPNMD-DNB

Target exams

FRANZCPMRCPsychABPNMD-DNB
Prompt
You are the psychiatry registrar. A 46-year-old woman has a first presentation of psychosis over 3 weeks. Her partner reports new word-finding difficulty and brief facial–arm jerks. She is on no psychotropics. Discuss differential, red-flag organic work-up (including when to image/LP), relationship to autoimmune encephalitis, symptomatic antipsychotic use, capacity, and communication with the medical team.

Interpretation

Reveal interpretation

Frame. This is not routine cannabis-FEP. Subacute psychosis plus speech change and possible faciobrachial dystonic seizure–like events push organic / autoimmune encephalitis to the top while keeping metabolic, infectious, and primary differentials open.[1][4]

Assessment spine. Risk, MSE with examples, attention (delirium screen), full neurologic bedside, collateral, capacity for MRI/LP, local MHA principles if detention needed (no invented section numbers), medication/substance timeline.[5]

Work-up. Tier 1 labs + ECG immediately. Escalate MRI, EEG, LP (after imaging if ICP risk), paired serum–CSF cell-based neuronal antibodies. Do not stop at normal MRI if AE still likely. Pollak autoimmune-psychosis and Graus AE frameworks guide urgency of immunotherapy discussion with neurology — detail of first-line IVIG/steroids/PLEX lives in the AE topic, but you must own recognition and hand-off.[2][3][4]

Symptomatic psychiatry. Low-dose antipsychotic if risk requires (e.g. olanzapine 2.5–5 mg oral) with monitoring; avoid aggressive D2 blockade if catatonia/NMS risk; benzos if catatonic features. Treat medical driver as primary.[5]

Communication. Explain to family: "symptoms may be driven by a treatable brain inflammatory or other medical process; we will investigate urgently; medicine and psychiatry work together."[2]

Key points

Red flags own the package

Speech change, seizure-like jerks, subacute tempo → MRI/EEG/CSF/Abs now.

Normal MRI is not clearance

Especially for anti-NMDAR disease.

Cause first, antipsychotic adjunct

Low dose, monitored, shortest effective course.
[2] [4] [5]

References

  1. [1]Keshavan MS, Kaneko Y Secondary psychoses: an update World Psychiatry, 2013.PMID 23471787
  2. [2]Pollak TA, Lennox BR, Müller S, et al. Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin Lancet Psychiatry, 2020.PMID 31669058
  3. [3]Graus F, Titulaer MJ, Balu R, et al. A clinical approach to diagnosis of autoimmune encephalitis Lancet Neurol, 2016.PMID 26906964
  4. [4]Herken J, Prüss H Red Flags: Clinical Signs for Identifying Autoimmune Encephalitis in Psychiatric Patients Front Psychiatry, 2017.PMID 28261116
  5. [5]Galletly C, Castle D, Dark F, et al. Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the management of schizophrenia and related disorders Aust N Z J Psychiatry, 2016.PMID 27106681