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EMERGENCY

Dengue Fever

High EvidenceUpdated: 2025-12-24

On This Page

Red Flags

  • Warning Signs (Abdominal Pain, Persistent Vomiting, Bleeding, Lethargy)
  • Dengue Shock Syndrome (DSS)
  • Severe Dengue (Plasma Leakage, Shock, Bleeding)
  • Thrombocytopenia <100,000
Overview

Dengue Fever

1. Topic Overview (Clinical Overview)

Summary

Dengue Fever is an acute viral illness caused by the Dengue virus (Flavivirus family), transmitted by the Aedes aegypti mosquito. There are 4 serotypes (DENV-1, 2, 3, 4). It is endemic in tropical and subtropical regions worldwide, with ~400 million infections/year. Dengue presents with sudden high fever, severe headache (especially retro-orbital), myalgia/arthralgia ("Breakbone Fever"), and a characteristic maculopapular rash ("Islands of white in a sea of red"). The illness progresses through three phases: Febrile -> Critical -> Recovery. The critical phase (around days 3-7) involves plasma leakage, thrombocytopenia, and risk of Dengue Shock Syndrome (DSS) and Dengue Haemorrhagic Fever (DHF). Importantly, second infection with a DIFFERENT serotype increases the risk of severe disease due to Antibody-Dependent Enhancement (ADE). Management is supportive (Fluids, Paracetamol, Monitoring). NSAIDs/Aspirin are contraindicated (Bleeding risk).

Key Facts

  • Vector: Aedes aegypti (daytime biting mosquito).
  • Serotypes: 4 (DENV-1, 2, 3, 4). Infection with one provides lifelong immunity to that serotype, but increases risk of severe disease on re-infection with a different serotype (ADE).
  • Incubation: 4-10 days.
  • Phases: Febrile (Days 1-3) -> Critical (Days 3-7 – Plasma Leak) -> Recovery (Days 7-10).
  • Classic Features: High fever, Retro-orbital headache, Myalgia ("Breakbone"), Maculopapular rash.
  • Warning Signs: Abdominal pain, Persistent vomiting, Lethargy, Bleeding, Rising Haematocrit.
  • Treatment: Supportive. Fluids. Paracetamol. NO NSAIDs/Aspirin.

Clinical Pearls

"Breakbone Fever": Severe myalgia and arthralgia are hallmarks of dengue – patients feel like their bones are breaking.

"Islands of White in a Sea of Red": The classic dengue rash spares small islands of normal skin.

"Watch the Haematocrit": Rising Haematocrit (Haemoconcentration) indicates plasma leakage -> Critical phase.

"Second Time is Worse": Heterotypic (Different serotype) re-infection causes severe dengue via ADE.

Why This Matters Clinically

Dengue is expanding globally due to climate change. Early recognition of warning signs and appropriate fluid management during the critical phase prevents mortality. NSAIDs/Aspirin are contraindicated.


2. Epidemiology

Incidence

  • Global Burden: ~400 million infections/year. ~100 million symptomatic.
  • Distribution: Tropical/Subtropical. SE Asia, Americas, Africa, Western Pacific.
  • Expanding Range: Climate change. Urbanisation. Travel.

Vector

MosquitoNotes
Aedes aegyptiPrimary vector. Daytime biter.
Aedes albopictusSecondary vector. Temperate climates.

Serotypes

SerotypeNotes
DENV-1Global.
DENV-2Associated with more severe disease.
DENV-3Global.
DENV-4Less common.

3. Pathophysiology

Mechanism

StepDetail
Mosquito BiteVirus inoculated.
Initial ReplicationIn Dendritic cells and Macrophages.
ViraemiaVirus in bloodstream -> Febrile phase.
Immune ActivationCytokine storm.
Plasma LeakageIncreased capillary permeability -> Haemoconcentration, Hypovolaemia.
ThrombocytopeniaBone marrow suppression. Platelet consumption.
RecoveryFluid reabsorption.

Antibody-Dependent Enhancement (ADE)

ConceptExplanation
First InfectionAntibodies develop against that serotype. Lifelong immunity to that serotype.
Second Infection (Different Serotype)Cross-reactive, non-neutralising antibodies ENHANCE viral uptake into cells.
ResultHigher viraemia. More severe disease. DHF/DSS.

Capillary Leak Syndrome (Critical Phase)

  • Plasma leaks from intravascular to interstitial space.
  • Pleural effusion, Ascites.
  • Haemoconcentration (Rising Haematocrit).
  • Hypovolaemia -> Shock (DSS).

4. Clinical Presentation

Phases of Illness

PhaseTimingFeatures
Febrile PhaseDays 1-3 (Up to 7)High fever (39-40°C), Headache, Retro-orbital pain, Myalgia, Arthralgia, Nausea/Vomiting, Rash.
Critical PhaseDays 3-7 (Around Defervescence)Plasma leakage, Rising Haematocrit, Thrombocytopenia, Warning Signs, Risk of DSS/DHF.
Recovery PhaseDays 7-10Fluid reabsorption, Improving platelets, Diuresis, Bradycardia. "Convalescent Rash".

Symptoms (Febrile Phase)

SymptomNotes
High FeverAbrupt onset. 39-40°C. Biphasic ("Saddleback").
Retro-Orbital HeadachePain behind the eyes (Characteristic).
Severe Myalgia / Arthralgia"Breakbone Fever".
Nausea / VomitingCommon.
Anorexia
RashMaculopapular. "Islands of white in a sea of red". Days 3-5.
BleedingMild: Petechiae, Gum bleeding, Epistaxis.

Warning Signs (Critical Phase)

WARNING SIGNS (Indicates Progression to Severe Dengue) | Warning Sign | Notes | |--------------|-------| | Abdominal Pain (Persistent / Severe) | Plasma leak (Ascites). Liver swelling. | | Persistent Vomiting | Cannot tolerate fluids. | | Lethargy / Restlessness | Altered consciousness. Impending shock. | | Mucosal Bleeding | Gum bleeding, Epistaxis, Haematemesis, Melaena. | | Hepatomegaly (>cm) | Liver involvement. | | Rising Haematocrit + Falling Platelets | Haemoconcentration. | | Pleural Effusion / Ascites | Clinical or Radiological. |

Severe Dengue (DSS / DHF)

FeatureNotes
Dengue Shock Syndrome (DSS)Severe plasma leak. Hypotension. Narrow Pulse Pressure (<20 mmHg). Cold peripheries. Tachycardia.
Dengue Haemorrhagic Fever (DHF)Plasma leak + Haemorrhage.
Severe Organ ImpairmentLiver (AST/ALT >000), Myocarditis, Encephalopathy.

5. Investigations

Bedside

TestNotes
Tourniquet Test (Positive)>0 petechiae per 2.5cm² after BP cuff inflation. Capillary fragility.
HaematocritRising = Haemoconcentration = Plasma leak.
Platelet CountThrombocytopenia (<100,000 = Warning sign).

Blood Tests

TestNotes
FBCLeucopenia. Thrombocytopenia. Rising Haematocrit.
Liver Function TestsElevated AST/ALT (AST > ALT typical).
Dengue NS1 AntigenPositive in first 5 days. Rapid diagnostic test.
Dengue IgM / IgGIgM positive from Day 5. IgG rises in secondary infection.
Coagulation (PT/APTT)May be deranged in severe.

Imaging

TestIndication
CXRPleural effusion (Critical phase).
USS AbdomenAscites. Gallbladder wall thickening.

6. WHO Classification (2009)

Dengue Classification

CategoryFeatures
Dengue Without Warning SignsFever + 2 of: Nausea/Vomiting, Rash, Aches, Leucopenia, Positive Tourniquet.
Dengue With Warning SignsAbove + Any Warning Sign.
Severe DengueSevere Plasma Leak (DSS, Fluid accumulation with respiratory distress), Severe Bleeding, Severe Organ Impairment.

7. Management

Principles

  1. Supportive Care.
  2. Fluid Management (Critical in Critical Phase).
  3. Monitor for Warning Signs.
  4. Avoid NSAIDs / Aspirin.
  5. Hospital Admission for Warning Signs / Severe Dengue.

Outpatient (Dengue Without Warning Signs)

InterventionDetail
Oral RehydrationEncourage fluids. ORS.
ParacetamolFor fever and pain.
Avoid NSAIDs / AspirinBleeding risk.
Daily FBCMonitor Haematocrit and Platelets.
Warning Sign EducationReturn immediately if any warning sign develops.

Inpatient (Warning Signs / Severe Dengue)

InterventionDetail
IV FluidsCrystalloid (0.9% Saline). Monitor Haematocrit. Aim to replace plasma loss.
If Shock (DSS)Rapid IV bolus (10-20mL/kg). Colloids if not responding.
Blood ProductsIf significant haemorrhage. Platelets rarely transfused unless active bleeding.
Monitor Closely4-6 hourly Haematocrit. Urine output. Vital signs.

Fluid Management in Critical Phase

ScenarioAction
Rising Haematocrit + Stable BPIncrease IV fluids.
Stable HaematocritReduce IV fluids.
Recovery Phase (Falling Haematocrit)Reduce/Stop IV fluids to avoid fluid overload.
ShockBolus. Colloid if refractory.

What NOT to Do

AvoidReason
NSAIDs / AspirinBleeding risk (Thrombocytopenia, Platelet dysfunction).
Over-Aggressive Fluids in RecoveryFluid overload. Pulmonary oedema.
Platelet Transfusion (Routinely)Rarely indicated unless active bleeding.

8. Complications
ComplicationNotes
Dengue Shock Syndrome (DSS)Hypovolaemic shock from plasma leak.
Dengue Haemorrhagic Fever (DHF)Bleeding diathesis.
Hepatic FailureElevated AST/ALT. Rare fulminant liver failure.
EncephalopathyRare. Metabolic or direct viral.
Myocarditis
Fluid Overload (Recovery Phase)From IV fluids during reabsorption phase.

9. Prognosis & Outcomes
ScenarioMortality
Uncomplicated Dengue<1%.
Dengue With Appropriate Fluid Management~1%.
Untreated DSS~10-20%.
Treated DSS<1% (With expert care).

Predictors of Severe Disease

  • Secondary infection (Different serotype).
  • DENV-2 serotype.
  • Children.
  • Delayed presentation.

10. Prevention

Vector Control

  • Eliminate standing water (Mosquito breeding sites).
  • Insecticides. Bed nets (Limited – Aedes bites daytime).
  • Personal protection (DEET, Long sleeves).

Vaccination

VaccineNotes
Dengvaxia (Sanofi)Live attenuated. Approved for those with prior dengue infection (Seropositive). Risk of ADE if seronegative.
Qdenga (Takeda)Live attenuated. Broader use potential.

11. Evidence & Guidelines

Key Guidelines

GuidelineOrganisationNotes
WHO Guidelines for DengueWorld Health OrganizationGlobal standard. 2009 Classification.
PHE/UKHSA GuidanceUK Health Security AgencyTraveller's health.

12. Exam Scenarios

Scenario 1:

  • Stem: A 30-year-old returns from Thailand with 5 days of high fever, severe headache (especially behind the eyes), and muscle aches. He has a maculopapular rash. What is the most likely diagnosis?
  • Answer: Dengue Fever.

Scenario 2:

  • Stem: What are the warning signs that indicate progression to severe dengue?
  • Answer: Abdominal pain (Persistent/Severe), Persistent vomiting, Lethargy/Restlessness, Mucosal bleeding, Rising Haematocrit + Falling Platelets.

Scenario 3:

  • Stem: Why is a second dengue infection with a different serotype more dangerous?
  • Answer: Antibody-Dependent Enhancement (ADE). Cross-reactive antibodies enhance viral uptake into macrophages, causing higher viraemia and severe disease.

14. Triage: When to Refer / Admit
ScenarioUrgencyAction
Dengue Without Warning SignsOutpatientHome with fluids. Paracetamol. Daily FBC. Education on Warning Signs.
Dengue With Warning SignsAdmitIV Fluids. Close monitoring.
Severe Dengue (Shock/DHF)EmergencyICU. Aggressive fluid resuscitation. HDU/ICU care.
All Dengue in PregnancyAdmitClose monitoring. Fetal risk.

15. Patient/Layperson Explanation

What is Dengue Fever?

Dengue is a viral infection spread by mosquitoes (Aedes – bites during the day). It causes high fever, severe headache, muscle pain ("Breakbone Fever"), and a rash.

What are the warning signs?

  • Severe stomach pain.
  • Vomiting that won't stop.
  • Bleeding from gums or nose.
  • Feeling very tired or restless.
  • If you have any of these, go to hospital immediately.

How is it treated?

  • Rest and fluids.
  • Paracetamol for fever and pain.
  • Do NOT take ibuprofen or aspirin (increases bleeding risk).

Key Counselling Points

  1. Stay Hydrated: "Drink plenty of fluids."
  2. Paracetamol Only: "Do not take ibuprofen or aspirin."
  3. Watch for Warning Signs: "Come back immediately if you have severe stomach pain, vomiting, or bleeding."

16. Quality Markers: Audit Standards
StandardTarget
NS1 / Dengue serology sent for suspected cases>0%
Haematocrit and Platelets monitored daily100% (Inpatients)
Warning Signs documented and explained to patient100%
NSAIDs/Aspirin avoided100%

17. Historical Context
  • Etymology: "Dengue" likely from Swahili "Ka-dinga pepo" (Disease caused by evil spirit).
  • First Recorded Outbreaks: 1779-1780 in Asia, Africa, North America (Likely Dengue).
  • Virus Isolated: 1943 (WWII, Pacific).
  • ADE Described: Halstead (1970s) – Explained severe dengue in secondary infections.

18. References
  1. WHO. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control. 2009. who.int
  2. Guzman MG, et al. Dengue. Lancet. 2015. PMID: 25529102


Medical Disclaimer: MedVellum content is for educational purposes and clinical reference. If you have fever after travel to a dengue-endemic area, please seek medical attention.

Last updated: 2025-12-24

At a Glance

EvidenceHigh
Last Updated2025-12-24
Emergency Protocol

Red Flags

  • Warning Signs (Abdominal Pain, Persistent Vomiting, Bleeding, Lethargy)
  • Dengue Shock Syndrome (DSS)
  • Severe Dengue (Plasma Leakage, Shock, Bleeding)
  • Thrombocytopenia &lt;100,000

Clinical Pearls

  • Critical (Days 3-7 – Plasma Leak) -
  • Recovery (Days 7-10).
  • **"Breakbone Fever"**: Severe myalgia and arthralgia are hallmarks of dengue – patients feel like their bones are breaking.
  • **"Islands of White in a Sea of Red"**: The classic dengue rash spares small islands of normal skin.
  • **"Watch the Haematocrit"**: Rising Haematocrit (Haemoconcentration) indicates plasma leakage -

Guidelines

  • NICE Guidelines
  • BTS Guidelines
  • RCUK Guidelines