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EMERGENCY

Febrile Convulsion (Seizure)

High EvidenceUpdated: 2025-12-25

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Red Flags

  • Seizure > 5 minutes (Status Epilepticus)
  • Focal neuro deficit (Post-ictal)
  • Signs of Meningitis (Neck stiffness, photophobia, non-blanching rash)
  • Age < 6 months or > 6 years
  • Complex febrile seizure features
Overview

Febrile Convulsion (Seizure)

1. Clinical Overview

Summary

A Febrile Convulsion (Seizure) is an epileptic seizure occurring in a child aged 6 months to 5 years, associated with fever, without evidence of intracranial infection or defined cause. It is the most common seizure type in childhood, affecting 2-5% of children. Seizures are classified as Simple (Generalised tonic-clonic, <15 mins, Single) or Complex (Focal, >15 mins, Recurring in 24h). The prognosis is generally excellent with no increased risk of death or neurodevelopmental deficit. Management involves resuscitation (ABCDE) if actively seizing, identifying the source of fever, and parental reassurance. Long-term antiepileptic prophylaxis is NOT indicated.

Key Facts

  • Definition: Seizure + Fever (Temp >38°C) in child 6m-5y, without CNS infection.
  • Prevalence: 2-5% of all children.
  • Peak Age: 18 months.
  • Recurrence Risk: ~30% overall. Higher if younger age at onset.
  • Epilepsy Risk: ~2-5% (Simple) vs ~10% (Complex). General population risk is 1%.
  • Management: Rectal/Buccal benzodiazepine if >5 mins. NO routine AEDs.

Clinical Pearls

"It looks worse than it is": Parents often think their child has died. The seizure is terrifying to witness (cyanosis, frothing, shaking) but rarely harmful. Parental anxiety management is the primary treatment.

"Antipyretics don't prevent seizures": Giving Paracetamol/Ibuprofen treats the fever and distress, but does NOT prevent the seizure from happening or recurring. (RCT evidence).

"Watch the age limits": A "febrile seizure" in a 3-month-old is MENINGITIS until proven otherwise. A "febrile seizure" in a 7-year-old is likely epilepsy triggered by fever.


2. Epidemiology

Demographics

  • Age: 6 months to 5 years (Standard definition).
  • Peak: 18 months of age.
  • Sex: Slight male preponderance (1.6:1).
  • Genetics: Strong familial tendency.
    • 25-40% have a positive family history.
    • Risk is 10-20% if a sibling has had one.
    • Autosomal dominant pattern with reduced penetrance in some families (FEB1-FEB11 loci).

3. Pathophysiology

Mechanisms

Why do developing brains seize with heat?

  1. Immature Brain: The growing brain has a lower seizure threshold. Increased excitability of neurons.
  2. Cytokine Storm: Fevers increase IL-1β (Interleukin-1 beta), which increases neuronal excitability in the hippocampus.
  3. Hyperventilation: Fever causes tachypnoea -> Respiratory Alkalosis -> Seizure threshold lowered.
  4. Genetic Susceptibility: Sodium channel mutations (SCN1A) associated with febrile seizures and Dravet Syndrome.

Viral Triggers

Common viral infections are the usual triggers:

  • HHV-6 (Roseola Infantum): Classic trigger. High fever -> Seizure -> Fever drops -> Rash appears.
  • Influenza A
  • Adenovirus
  • Otitis Media / Tonsillitis

4. Classification

Simple vs Complex

Distinction is critical for prognosis and investigation.

FeatureSimple Febrile SeizureComplex Febrile Seizure
Prevalence70-75%20-25%
Duration< 15 minutes> 15 minutes
MorphologyGeneralised Tonic-ClonicFocal (one side)
RecurrenceSingle in 24 hoursMultiple in 24 hours
Post-IctalRapid recoveryTodd's Paresis (Focal weakness)
Epilepsy RiskSlightly > Population (~2%)Increased (~5-10%)

Febrile Status Epilepticus

  • Febrile seizure lasting > 30 minutes.
  • Accounts for 5% of all cases.
  • Medical emergency.

5. Clinical Presentation

History

Examination

Red Flags (Admit/Investigate)


The Event
"Did they go stiff? Did they shake? Were eyes rolled back?"
Duration
Time it! (Parents often overestimate).
Recovery
How long to wake up? Any weakness after?
The Fever
Documented? Prior illness (cough, coryza, diarrhoea)?
Vaccination
Recent mmR (measles) can cause fever 7-10 days later.
6. Investigations

"Less is More"

For a Simple Febrile Seizure in a well child with a clear source (e.g. Tonsillitis):

  • NO bloods needed.
  • NO imaging needed.
  • NO EEG needed.

When to Investigate

InvestigationIndicationNote
Urine DipNo clear focus of infectionUTI is common cause.
Bloods (FBC/CRP)Unwell child / Diagnostic uncertaintyLook for bacterial cause.
Blood GlucoseAltered conscious stateExclude hypoglycaemia.
U&Es / CalciumHistory of D&V / TwitchingHyponatraemia seizure mimics febrile seizure.
Lumbar PunctureMeningeal signs / <12m with ongoing fever / Complex seizure / Prior antibiotics masking meningitisGold Standard for CNS infection.
CT/MRI BrainFocal neurological deficit / Signs of raised ICPExclude abscess/tumour.
EEGRepeated complex seizuresLimited value in acute setting.

7. Management Algorithm
           CHILD SEIZING + FEVER
                     ↓
        ASSESS SAFETY (ABCDE)
        - Airway (Position lateral/Suction)
        - High Flow Oxygen
                     ↓
          TIME THE SEIZURE
             &lt; 5 Minutes?            &gt; 5 Minutes?
                 ↓                         ↓
           SUPPORTIVE CARE           ACUTE TREATMENT
           - Do NOT restrain         - Benzodiazepine
           - Cool environment        - Call for help
                     ↓
           POST-ICTAL PHASE
           - Treat Fever (Paracetamol/Ibuprofen)
           - Find Source (Ears/Throat/Urine)
           - Observation

1. Acute Management (Seizure > 5 mins)

Follow APLS (Advanced Paediatric Life Support) guidelines.

  1. Buccal Midazolam: 0.5mg/kg.
    • 6m-1y: 2.5mg.
    • 1y-5y: 5mg.
    • 5y-10y: 7.5mg.
  2. Rectal Diazepam: If Midazolam unavailable.
  3. IV Lorazepam: 0.1mg/kg (If IV access obtained).

2. Post-Seizure Management

  • Observe: Until GCS 15/15.
  • Antipyretics: Paracetamol 15mg/kg / Ibuprofen 10mg/kg for comfort.
  • Antibiotics: Only if bacterial source identified (e.g. Otitis Media, UTI).

3. Prevention (Prophylaxis)

  • Continuous prophylaxis (Daily AEDs): NOT RECOMMENDED. Side effects (behaviour/sedation) outweigh risk of benign seizures.
  • Intermittent prophylaxis (Home Rescue):
    • Prescribe Buccal Midazolam for home use IF:
      • History of prolonged seizures (>5 min).
      • Cluster seizures.
      • Live remotely (>30 mins from ambulance).

8. Deep Dive: Risk of Future Epilepsy

"Will my child be epileptic?" This is the parents' #1 question.

  • Baseline Risk: 1 in 100 (1%) of general population develop epilepsy.
  • Simple Febrile Seizure: Risk rises to 2% (Barely increased).
  • Complex Febrile Seizure: Risk rises to 5-10%.
  • Risk Factors for Epilepsy:
    1. Neurodevelopmental abnormality (Cerebral palsy).
    2. Complex febrile seizure.
    3. Family history of Epilepsy (Not just febrile Sz).
    4. Short fever duration before seizure (<1 hour) - suggests low threshold.

9. Technical Appendix: Lumbar Puncture Decision

The "Grey Area". When to LP a febrile seizing child?

  • AAP Guidelines (American Academy of Pediatrics):
    • Definitely: Meningeal signs.
    • Strongly Consider: Infants 6-12 months unimmunised for Hib/Pneumococcus.
    • Consider: Patients on prior antibiotics (masks signs).
  • Clinical Reality: If the child wakes up, looks well, interacts, and has no neck stiffness -> LP usually not done. If child remains drowsy/irritable -> LP mandatory.

10. Rehabilitation: Parental Education

"Fever Phobia". Parents often become obsessed with measuring temperature after a seizure.

  • Educate:
    • "Seizures can happen at 38°C or 40°C. Only the speed of rise matters."
    • "Giving Calpol will make them feel better, but scientific studies show it does not stop the fit."
    • "Put them in the recovery position. Time it. Do not put a spoon in their mouth."
    • "Call ambulance if: >5 mins, or one side shaking, or not waking up."

11. Evidence and Guidelines

Key Guidelines

  • NICE NG143 (Fever in under 5s): Traffic light system for assessing risk.
  • APLS: Status Epilepticus algorithm.

Key Reviews

  • Cochrane: Antipyretics for preventing febrile seizure recurrence.
    • Result: No significant reduction in seizure recurrence vs placebo.

12. Patient/Layperson Explanation

What happened?

Your child had a "Febrile Convulsion". This is a seizure triggered by a rapid rise in body temperature (fever). It happens because young brains are sensitive to heat. It is very common (1 in 20 children).

Did it damage their brain?

No. Simple febrile seizures are frightening but harmless. They do not cause brain damage, blindness, or learning difficulties.

Will it happen again?

It might. About 1 in 3 children will have another one with a future illness. This becomes less likely as they get older, and usually stops completely by age 6.

Does this mean they have Epilepsy?

No. Epilepsy is when seizures happen without a fever. Most children grow out of febrile seizures and never have a seizure again.

What should I do next time?

  1. Safety: Place them on their side on a soft surface.
  2. Time it.
  3. Do not panic: It usually stops in 2-3 minutes.
  4. Call 999 if: It lasts more than 5 minutes, or they don't wake up.

13. References
  1. NICE. Fever in under 5s: assessment and initial management (NG143). 2019.
  2. Patel N, et al. Febrile seizures. BMJ. 2015;351:h4240.
  3. American Academy of Pediatrics. Febrile Seizures: Guideline for the Neurodiagnostic Evaluation of the Child With a Simple Febrile Seizure. Pediatrics. 2011.

(End of File)

Last updated: 2025-12-25

At a Glance

EvidenceHigh
Last Updated2025-12-25
Emergency Protocol

Red Flags

  • Seizure &gt; 5 minutes (Status Epilepticus)
  • Focal neuro deficit (Post-ictal)
  • Signs of Meningitis (Neck stiffness, photophobia, non-blanching rash)
  • Age &lt; 6 months or &gt; 6 years
  • Complex febrile seizure features

Clinical Pearls

  • **"Antipyretics don't prevent seizures"**: Giving Paracetamol/Ibuprofen treats the *fever* and distress, but does NOT prevent the seizure from happening or recurring. (RCT evidence).
  • **"Watch the age limits"**: A "febrile seizure" in a 3-month-old is MENINGITIS until proven otherwise. A "febrile seizure" in a 7-year-old is likely epilepsy triggered by fever.
  • Respiratory Alkalosis -
  • Seizure threshold lowered.
  • Population (~2%) | Increased (~5-10%) |

Guidelines

  • NICE Guidelines
  • BTS Guidelines
  • RCUK Guidelines