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ENT
Paediatrics
General Practice

Acute Tonsillitis

High EvidenceUpdated: 2025-12-25

On This Page

Red Flags

  • Stridor (Airway compromise)
  • Trismus (Quinsy)
  • Drooling (Epiglottitis)
  • Systemic Sepsis
  • Post-Tonsillectomy Bleeding (Emergency)
Overview

Acute Tonsillitis

1. Clinical Overview

Summary

Acute Tonsillitis is inflammation of the palatine tonsils, usually part of a wider pharyngitis. It is extremely common in children and young adults. The majority of cases (70-80%) are Viral (Adenovirus, Rhinovirus, EBV) and self-limiting. Bacterial cases (Group A Beta-Haemolytic Streptococcus - GABHS) require antibiotics to shorten duration and prevent complications like Rheumatic Fever (though rare in developed nations). The key clinical skill is distinguishing bacterial from viral infection using the Centor or FeverPAIN criteria. Major complications include Peritonsillar Abscess (Quinsy), which presents with trismus and requires drainage, and Deep Neck Space Infections. Recurrent severe tonsillitis is treated with Tonsillectomy, which carries a significant risk of delayed haemorrhage.

Key Facts

  • Most Common Cause: Viral (70%).
  • Most Common Bacterial: Streptococcus Pyogenes (Group A Strep).
  • Antibiotic of Choice: Phenoxymethylpenicillin (Penicillin V).
  • Contraindication: Amoxicillin/Ampicillin must be avoided if Glandular Fever (EBV) is suspected, as it causes a severe maculopapular rash.
  • Quinsy: Collection of pus between the tonsil capsule and the superior constrictor muscle.

Clinical Pearls

"Hot Potato Voice": The muffled, thick speech of a patient with severe tonsillar swelling or Quinsy. It sounds like they are holding a hot potato in their mouth to avoid burning their tongue.

"Trismus is the tell": If a patient with sore throat CANNOT OPEN THEIR MOUTH (Trismus), it is a Quinsy until proven otherwise. Inflammation of the pterygoid muscles causes the spasm.

"Kissing Tonsils": When both tonsils are so huge they touch in the midline. In a child, checking O2 sats is vital – they can obstruct their airway when they sleep (OSA).

"The EBV Rash": If you give Amoxicillin to a teenager with a sore throat and they come back covered in a bright red rash, you have just diagnosed Glandular Fever (infectious mononucleosis).


2. Epidemiology

Demographics

  • Peak Age: 5-15 years.
  • Viral: Any age, winter peaks.
  • Bacterial: Rare <2 years old. Common school age.

Transmission

  • Droplet spread. Highly contagious.
  • Incubation: 2-4 days.

3. Pathophysiology

Anatomy: Waldeyer's Ring

Lymphoid tissue guarding the aerodigestive tract.

  • Palatine Tonsils: The "Tonsils" (Oropharynx).
  • Adenoids: Nasopharyngeal tonsils.
  • Lingual Tonsils: Base of tongue.
  • Tubal Tonsils: Around Eustachian tube opening.

Microbiology

  • Viral: Adenovirus, EBV, Cytomegalovirus.
  • Bacterial:
    • Strep pyogenes (Lancefield Group A Beta-haemolytic).
    • Staphylococcus aureus.
    • Haemophilus influenzae.
    • Anaerobes (Fusobacterium) - Associated with Lemierre's Syndrome.

4. Clinical Presentation

Symptoms

Signs

Warning Signs (Sepsis/Airway)


Sore Throat
Severe, sharp pain.
Odynophagia
Painful swallowing.
Fever
>38°C.
Otalgia
Referred ear pain (via Glossopharyngeal nerve - Jacobson's nerve).
Halitosis
Bad breath.
5. Investigations

Scoring Systems (To swab or not to swab?)

The Centor Criteria

One point for each:

  1. Cough absent.
  2. Exudate on tonsils.
  3. Nodes (Tender anterior cervical).
  4. Temperature (History of fever >38).
  • Score 0-2: Viral likely. No Abx.
  • Score 3-4: Bacterial likely (40-60%). Consider Abx or delayed script.

FeverPAIN Score

(Fever, Purulence, Attend <3 days, Inflamed tonsils, No cough).

  • Often preferred in UK Primary Care (NICE NG84).

Laboratory

  • Throat Swab: For culture. Takes 48 hours.
  • Rapid Strep Test: Antigen detection. Quick but less sensitive.
  • Monospot (Paul-Bunnell): For EBV. (May be negative in first week).
  • FBC: High WCC (Neutrophilia = Bacterial, Lymphocytosis + Atypical cells = Viral/EBV).
  • LFTs: Often deranged in Glandular Fever.

6. Management Algorithm
          PATIENT WITH SORE THROAT
                     ↓
        ASSESS SEVERITY (Airway/Sepsis?)
         Assess TRISMUS (Quinsy?)
                     ↓
      ┌──────────────┼───────────────┐
    SEVERE         QUINSY          SIMPLE
  (Dehydrated/    (Abscess)       TONSILLITIS
   Airway risk)      |               ↓
      ↓              ↓          CENTOR SCORE?
    ADMIT         ADMIT +       ┌────┴────┐
   IV FLUIDS     DRAINAGE      0-2       3-4
   IV ABX        IV ABX         ↓         ↓
   STEROIDS                     NO ABX   CONSIDER
                             (Supportive) PEN V

1. Supportive Care (First Line)

  • Analgesia: Paracetamol + Ibuprofen. (Crucial to enable swallowing).
  • Hydration: Sips of water.
  • Topical: Difflam (Benzydamine) spray/gargle.

2. Antibiotics

  • Indication: Centor 3-4, Systemically unwell, Immunocompromised.
  • First Line: Phenoxymethylpenicillin (Penicillin V) 500mg QDS for 10 days.
  • Allergy: Clarithromycin or Erythromycin.
  • Avoid: Amoxicillin (Risk of rash if EBV).

3. Steroids

  • Dexamethasone: Single dose (e.g. 6.6mg or 8mg) reduces pain and swelling. Used in severe hospital cases (SIGN 117).

7. Complications

Peritonsillar Abscess (Quinsy)

  • Pathology: Pus between tonsil and muscle.
  • Signs: Trismus, Uvula deviated away from lesion, Unilateral swelling.
  • Tx: Needle Aspiration or Incision & Drainage. IV Abx.

Deep Neck Space Infection

  • Parapharyngeal / Retropharyngeal abscess.
  • Danger: Airway obstruction, erosion into Carotid Artery.

Lemierre's Syndrome

  • Pathology: Thrombophlebitis of the Internal Jugular Vein (IJV) caused by Fusobacterium necrophorum.
  • Presentation: Sore throat -> Sepsis -> Septic emboli to Lungs ("Cannonball metastases").

Post-Streptococcal

  • Rheumatic Fever (Heart valves).
  • Glomerulonephritis (Kidney).
  • Scarlet Fever (Sandpaper rash, Strawberry tongue).

8. Surgical Atlas: Tonsillectomy

Indications (SIGN 117 / Paradise Criteria)

"The Rule of 7-5-3"

  1. 7 episodes in the last 1 year.
  2. 5 episodes/year for 2 years.
  3. 3 episodes/year for 3 years.
  • Episodes must be disabling preventing normal function.
  • Other indications: Quinsy x2, Suspected Malignancy (Unilateral enlargement), Sleep Apnoea (OSA).

Technique (Dissection Tonsillectomy)

  1. Position: "Rose position" (Neck extended, mouth gag).
  2. Dissection: Tonsil grasped. Mucosa incised.
  3. Plane: Dissected in the loose plane between tonsil capsule and muscular bed (Superior Constrictor).
  4. Haemostasis: Bipolar diathermy or Ties. (Note: Diathermy increases pain but reduces intra-op blood. Cold steel reduces pain).
  5. Poles: Superior and Inferior poles are vascular.

9. Technical Appendix: Post-Tonsillectomy Blead

A Major ENT Emergency.

TypeTimingCauseManagement
Primary<24 hoursSurgical technique. Slipped ligature.Return to Theatre.
Reactionary<24 hoursBP rising post-op. Clot displacement.Return to Theatre.
Secondary5-10 daysInfection. The scab (eschar) falls off, exposing a vessel.Admit. IV Abx. Hydrogen Peroxide gargles. Tranexamic acid. Surgery usually NOT needed unless torrential.

10. Deep Dive: Glandular Fever (EBV)

Infectious Mononucleosis

  • Etiology: Epstein-Barr Virus.
  • Adolescents: "Kissing Disease".
  • Features:
    • Severe tonsillitis (thick creamy exudate).
    • Posterior Cervical Lymphadenopathy.
    • Hepatosplenomegaly (Risk of splenic rupture).
    • Fatigue (can last months).
  • Diagnosis: Monospot +ve. Lymphocytosis.
  • Advice: NO CONTACT SPORTS for 6-8 weeks (risk of splenic rupture). No alcohol (Liver).

11. Evidence and Guidelines

Landmark Trials

  1. Paradise Study: Established the 7/5/3 criteria compared to conservative management.
  2. N-ICE Trial: Coblation vs Dissection tonsillectomy. Coblation has less pain but slightly higher bleed rate.

NICE NG84

  • Do not prescribe antibiotics for typical viral sore throats.
  • Use FeverPAIN or Centor to guide prescribing.
  • Safety net: "Come back if not better in 1 week or unable to swallow".

12. Patient/Layperson Explanation

What is Tonsillitis?

It is swelling of the tonsils (the two lumps at the back of your throat). It is usually caused by a virus (like a cold) but sometimes by bacteria (Strep).

Do I need antibiotics?

Usually, no. Most cases get better on their own in 3-4 days. Antibiotics only shorten the illness by about 12 hours and can cause side effects. We save them for severe cases (high fever, pus spots).

Why can't I play rugby? (Glandular Fever)

If you have Glandular Fever, your spleen (an organ under your left ribs) swells up. It becomes fragile. A tackle or fall could cause it to burst, which causes dangerous internal bleeding. You must avoid contact sports for a few weeks.

When should I have my tonsils out?

We don't take them out as often as we used to. We only do it if you are having severe tonsillitis again and again (e.g. 7 times in a year) and it is affecting your school or work.


13. References
  1. SIGN 117. Management of Sore Throat and Indications for Tonsillectomy. 2010.
  2. NICE NG84. Sore throat (acute): antimicrobial prescribing. 2018.

(End of File)

Last updated: 2025-12-25

At a Glance

EvidenceHigh
Last Updated2025-12-25

Red Flags

  • Stridor (Airway compromise)
  • Trismus (Quinsy)
  • Drooling (Epiglottitis)
  • Systemic Sepsis
  • Post-Tonsillectomy Bleeding (Emergency)

Clinical Pearls

  • **"Hot Potato Voice"**: The muffled, thick speech of a patient with severe tonsillar swelling or Quinsy. It sounds like they are holding a hot potato in their mouth to avoid burning their tongue.
  • **"Trismus is the tell"**: If a patient with sore throat CANNOT OPEN THEIR MOUTH (Trismus), it is a Quinsy until proven otherwise. Inflammation of the pterygoid muscles causes the spasm.
  • **"Kissing Tonsils"**: When both tonsils are so huge they touch in the midline. In a child, checking O2 sats is vital – they can obstruct their airway when they sleep (OSA).
  • **"The EBV Rash"**: If you give Amoxicillin to a teenager with a sore throat and they come back covered in a bright red rash, you have just diagnosed Glandular Fever (infectious mononucleosis).
  • Septic emboli to Lungs ("Cannonball metastases").

Guidelines

  • NICE Guidelines
  • BTS Guidelines
  • RCUK Guidelines