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EMERGENCY

Acute Appendicitis - Paediatric

High EvidenceUpdated: 2025-12-25

On This Page

Red Flags

  • Signs of perforation (severe pain, peritonism)
  • Signs of sepsis
  • Severe dehydration
  • Altered mental status
  • Signs of shock
Overview

Acute Appendicitis - Paediatric

1. Clinical Overview

Summary

Acute appendicitis in children is inflammation of the appendix, a small pouch attached to the large intestine. Think of the appendix as a small, dead-end tube—when it gets blocked (usually by stool or lymphoid tissue), bacteria multiply inside, causing inflammation, swelling, and eventually rupture if not treated. Appendicitis is the most common surgical emergency in children, with a peak incidence in older children and adolescents (10-15 years), though it can occur at any age. The presentation in children can be different from adults—younger children may have less specific symptoms (vomiting, fever, irritability) and may present later, making diagnosis more challenging. The key to management is recognizing the condition (abdominal pain, especially migrating to right lower quadrant, fever, vomiting), confirming the diagnosis (clinical assessment, sometimes imaging), and urgent surgical removal (appendicectomy) before rupture. Most children recover well with prompt surgery, but delayed diagnosis can lead to perforation, peritonitis, and more serious complications.

Key Facts

  • Definition: Acute inflammation of the appendix
  • Incidence: Very common (most common surgical emergency in children)
  • Mortality: Very low (<0.1%) unless complications
  • Peak age: Older children and adolescents (10-15 years), but can occur at any age
  • Critical feature: Abdominal pain (often migrating to right lower quadrant), fever, vomiting
  • Key investigation: Clinical diagnosis (usually), ultrasound/CT if uncertain
  • First-line treatment: Urgent surgical removal (appendicectomy)

Clinical Pearls

"Presentation varies by age" — Younger children (<5 years) often have less specific symptoms (vomiting, fever, irritability) and may present later, making diagnosis more challenging. Always consider appendicitis in children with abdominal pain.

"Migration of pain is classic" — The pain often starts around the umbilicus (belly button) and then migrates to the right lower quadrant. This is a classic feature, though not always present, especially in younger children.

"Don't delay surgery" — Once appendicitis is diagnosed, surgery should be done promptly to prevent rupture. Delayed surgery increases the risk of perforation and complications.

"Younger children are at higher risk of perforation" — Younger children (<5 years) have a higher risk of perforation because they present later and have less specific symptoms. Have a lower threshold for investigation in younger children.

Why This Matters Clinically

Appendicitis is the most common surgical emergency in children and can be life-threatening if not treated promptly. Early recognition (especially in younger children where symptoms may be less specific), prompt diagnosis, and urgent surgery are essential to prevent complications (perforation, peritonitis). This is a condition that pediatricians, emergency clinicians, and surgeons manage frequently, and prompt treatment leads to excellent outcomes.


2. Epidemiology

Incidence & Prevalence

  • Overall: Very common (most common surgical emergency in children)
  • Peak age: Older children and adolescents (10-15 years)
  • Trend: Stable (common condition)
  • Peak age: 10-15 years (but can occur at any age)

Demographics

FactorDetails
AgePeak 10-15 years (but can occur at any age, even infants)
SexSlight male predominance
EthnicityNo significant variation
GeographyWorldwide, no significant variation
SettingEmergency departments, pediatric surgery

Risk Factors

Non-Modifiable:

  • Age (peak 10-15 years)
  • Male sex (slight)

Modifiable:

Risk FactorRelative RiskMechanism
None significantN/AN/A

Common Presentations

PresentationFrequencyTypical Patient
Classic (older children)60-70%Older children, typical symptoms
Atypical (younger children)30-40%Younger children, less specific symptoms

3. Pathophysiology

The Inflammation Cascade

Step 1: Obstruction

  • Blockage: Appendix gets blocked (stool, lymphoid tissue, foreign body)
  • Result: Contents can't drain

Step 2: Bacterial Multiplication

  • Bacteria: Bacteria multiply inside blocked appendix
  • Result: Increased pressure, inflammation

Step 3: Inflammation

  • Swelling: Appendix swells
  • Ischemia: Blood supply compromised
  • Result: Tissue damage

Step 4: Perforation (If Not Treated)

  • Rupture: Appendix ruptures
  • Peritonitis: Contents spill into abdomen
  • Result: Serious infection

Classification by Stage

StageDefinitionClinical Features
Simple appendicitisInflamed, not rupturedPain, fever, no peritonitis
Gangrenous appendicitisTissue death, not rupturedMore severe, may have peritonitis
Perforated appendicitisRupturedPeritonitis, sepsis risk

Anatomical Considerations

Appendix Location:

  • Right lower quadrant: Usually (but can vary)
  • Retrocecal: Sometimes behind cecum (can cause atypical presentation)
  • Pelvic: Sometimes in pelvis (can cause urinary symptoms)

Why Children are Different:

  • Less specific symptoms: Especially younger children
  • Later presentation: May present later
  • Higher perforation risk: Especially younger children

4. Clinical Presentation

Symptoms: The Patient's Story

Typical Presentation (Older Children):

Atypical Presentation (Younger Children):

History:

Signs: What You See

Vital Signs (May Be Abnormal):

SignFindingSignificance
TemperatureUsually elevated (37.5-39°C)Fever
Heart rateMay be high (fever, pain)Tachycardia
Blood pressureUsually normal (may be low if sepsis)Usually normal
Respiratory rateUsually normal (may be high if pain)Usually normal

General Appearance:

Abdominal Examination:

FindingWhat It MeansFrequency
Right lower quadrant tendernessAppendicitis80-90%
Rebound tendernessPeritonitis50-60%
GuardingPeritonitis40-50%
Rovsing's signAppendicitis30-40%
Psoas signRetrocecal appendicitis20-30%

Signs of Complications:

Red Flags

[!CAUTION] Red Flags — Immediate Escalation Required:

  • Signs of perforation (severe pain, peritonism) — Medical emergency, needs urgent surgery
  • Signs of sepsis — Medical emergency, needs urgent treatment
  • Severe dehydration — Needs IV fluids
  • Altered mental status — May indicate severe sepsis
  • Signs of shock — Medical emergency, needs urgent resuscitation

Abdominal pain
Starts around umbilicus, migrates to right lower quadrant
Fever
Usually present
Vomiting
Common
Loss of appetite
Common
Diarrhea
Less common (constipation more common)
5. Clinical Examination

Structured Approach: ABCDE

A - Airway

  • Assessment: Usually patent
  • Action: Secure if compromised

B - Breathing

  • Look: Usually normal (may have shallow breathing if pain)
  • Listen: Usually normal
  • Measure: SpO2 (usually normal)
  • Action: Support if needed

C - Circulation

  • Look: May have signs of dehydration, sepsis
  • Feel: Pulse (may be high), BP (usually normal, may be low if sepsis)
  • Listen: Heart sounds (usually normal)
  • Measure: BP (usually normal), HR (may be high)
  • Action: IV fluids if dehydrated, monitor if sepsis

D - Disability

  • Assessment: Usually normal (may be altered if sepsis)
  • Action: Assess if severe

E - Exposure

  • Look: Abdominal examination
  • Feel: Tenderness, guarding, rebound
  • Action: Complete examination

Specific Examination Findings

Abdominal Examination:

  • Inspection: May have distension (if perforated)
  • Palpation:
    • Right lower quadrant tenderness: Classic
    • Rebound tenderness: Peritonitis
    • Guarding: Peritonitis
  • Special tests:
    • Rovsing's sign: Pain in right lower quadrant when pressing left lower quadrant
    • Psoas sign: Pain when extending right hip (retrocecal)
    • Obturator sign: Pain when flexing and rotating right hip (pelvic)

Special Tests

TestTechniquePositive FindingClinical Use
Rovsing's signPress left lower quadrantPain in right lower quadrantSuggests appendicitis
Psoas signExtend right hipPainRetrocecal appendicitis
Obturator signFlex and rotate right hipPainPelvic appendicitis

6. Investigations

First-Line (Bedside) - Do Immediately

1. Clinical Diagnosis (Usually Sufficient)

  • History: Abdominal pain, fever, vomiting
  • Examination: Right lower quadrant tenderness
  • Action: Usually sufficient for diagnosis in older children

2. Laboratory Tests (Supportive)

  • Full Blood Count: Usually shows leukocytosis
  • CRP: Usually elevated
  • Action: Supports diagnosis, but not diagnostic

Laboratory Tests

TestExpected FindingPurpose
Full Blood CountLeukocytosis (elevated white cells)Supports diagnosis
CRPElevatedSupports diagnosis
Urea & ElectrolytesUsually normal (may show dehydration)Assesses hydration

Imaging

Ultrasound (First-Line in Children):

IndicationFindingClinical Note
Uncertain diagnosisEnlarged appendix, wall thickening, fluidDiagnostic, preferred in children

CT (If Needed):

IndicationFindingClinical Note
Uncertain diagnosisEnlarged appendix, inflammation, perforationIf ultrasound inconclusive

Note: Avoid CT in children if possible (radiation exposure)

Diagnostic Criteria

Clinical Diagnosis:

  • Abdominal pain (especially migrating to right lower quadrant) + fever + vomiting + right lower quadrant tenderness = Appendicitis

Severity Assessment:

  • Simple: Inflamed, not ruptured
  • Gangrenous: Tissue death, not ruptured
  • Perforated: Ruptured, peritonitis

7. Management

Management Algorithm

        SUSPECTED APPENDICITIS (CHILD)
    (Abdominal pain + fever + vomiting)
                    ↓
┌─────────────────────────────────────────────────┐
│         CLINICAL ASSESSMENT                      │
│  • History (pain, fever, vomiting)               │
│  • Examination (right lower quadrant tenderness) │
│  • Laboratory tests (FBC, CRP)                   │
└─────────────────────────────────────────────────┘
                    ↓
┌─────────────────────────────────────────────────┐
│         IMAGING (IF UNCERTAIN)                    │
│  • Ultrasound (preferred in children)             │
│  • CT (if ultrasound inconclusive)               │
└─────────────────────────────────────────────────┘
                    ↓
┌─────────────────────────────────────────────────┐
│         DIAGNOSIS CONFIRMED                      │
│  • Simple appendicitis                            │
│  • Gangrenous appendicitis                        │
│  • Perforated appendicitis                        │
└─────────────────────────────────────────────────┘
                    ↓
┌─────────────────────────────────────────────────┐
│         PRE-OPERATIVE PREPARATION                 │
│  • IV fluids (if dehydrated)                      │
│  • Antibiotics (pre-operative)                     │
│  • Analgesia                                       │
│  • NPO (nothing by mouth)                         │
└─────────────────────────────────────────────────┘
                    ↓
┌─────────────────────────────────────────────────┐
│         URGENT SURGERY                           │
│  • Appendicectomy (laparoscopic or open)          │
│  • Remove appendix                                 │
│  • Irrigate if perforated                          │
└─────────────────────────────────────────────────┘
                    ↓
┌─────────────────────────────────────────────────┐
│         POST-OPERATIVE                           │
│  • Continue antibiotics (if perforated)            │
│  • Monitor for complications                      │
│  • Usually discharge within 1-2 days (simple)     │
└─────────────────────────────────────────────────┘

Acute/Emergency Management - The First Hour

Immediate Actions (Do Simultaneously):

  1. Clinical Assessment

    • History: Pain, fever, vomiting
    • Examination: Right lower quadrant tenderness
    • Action: Assess severity, complications
  2. IV Access and Fluids

    • IV cannula: Establish IV access
    • IV fluids: If dehydrated
    • Action: Support circulation
  3. Antibiotics (Pre-Operative)

    • Broad-spectrum: Co-amoxiclav or cefuroxime + metronidazole
    • Action: Reduce infection risk
  4. Analgesia

    • Paracetamol: 15mg/kg PO/IV
    • Morphine: If severe pain
    • Action: Relieve pain
  5. Surgical Consultation

    • Urgent: Appendicectomy
    • Action: Don't delay surgery

Medical Management

Antibiotics (Pre-Operative and Post-Operative if Perforated):

DrugDoseRouteDurationNotes
Co-amoxiclav30mg/kg (max 1.2g)IVTDSPre-op and post-op if perforated
Cefuroxime + MetronidazoleAs appropriateIVTDSAlternative

Analgesia:

DrugDoseRouteNotes
Paracetamol15mg/kgPO/IVRegular
Ibuprofen10mg/kgPOTDS (if no contraindications)
Morphine0.1-0.2mg/kgIVAs needed (if severe)

Surgical Management

Appendicectomy (Essential):

ApproachIndicationNotes
LaparoscopicPreferredLess invasive, faster recovery
OpenIf laparoscopic not availableTraditional approach

Procedure:

  • Remove appendix: Surgical removal
  • Irrigate: If perforated
  • Drain: If abscess

Disposition

Admit to Hospital:

  • All cases: Need surgery, monitoring
  • Regular follow-up: Monitor recovery

Discharge Criteria:

  • Post-operative: After surgery, stable
  • Simple appendicitis: Usually discharge within 1-2 days
  • Perforated: Longer stay (3-5 days)

Follow-Up:

  • Wound: Monitor wound healing
  • Recovery: Usually quick recovery
  • Long-term: Usually no long-term issues

8. Complications

Immediate (Days-Weeks)

ComplicationIncidencePresentationManagement
Perforation20-30% (higher in younger children)Peritonitis, sepsisSurgery, antibiotics
Peritonitis20-30% (if perforated)Severe pain, peritonismSurgery, antibiotics
Sepsis5-10% (if perforated)Fever, tachycardia, hypotensionIV antibiotics, supportive care
Wound infection5-10%Redness, dischargeAntibiotics, may need drainage

Perforation:

  • Mechanism: Appendix ruptures
  • Management: Surgery, antibiotics
  • Prevention: Early surgery

Early (Weeks-Months)

1. Abscess Formation (5-10% if perforated)

  • Mechanism: Localized infection
  • Management: Drainage, antibiotics
  • Prevention: Early surgery

2. Adhesions (5-10%)

  • Mechanism: Scar tissue from surgery
  • Management: Usually asymptomatic, may need surgery if symptomatic
  • Prevention: Minimize trauma during surgery

Late (Months-Years)

1. Usually Full Recovery (90-95%)

  • Mechanism: Most recover completely
  • Management: Usually no long-term treatment needed
  • Prevention: N/A

9. Prognosis & Outcomes

Natural History (Without Treatment)

Untreated Appendicitis:

  • High risk of perforation: Almost certain if not treated
  • Peritonitis: High risk
  • Sepsis: High risk
  • Mortality: High if not treated

Outcomes with Treatment

VariableOutcomeNotes
Recovery95-98%Most recover completely
Perforation20-30% (higher in younger children)If delayed diagnosis
Mortality<0.1%Very low with prompt treatment
RecurrenceVery rareAppendicectomy is curative

Factors Affecting Outcomes:

Good Prognosis:

  • Early surgery: Better outcomes
  • Simple appendicitis: Usually quick recovery
  • No perforation: Better outcomes
  • Older children: Usually better outcomes

Poor Prognosis:

  • Delayed surgery: Higher risk of perforation
  • Perforation: Longer recovery, more complications
  • Younger children: Higher risk of perforation
  • Sepsis: More serious

Prognostic Factors

FactorImpact on PrognosisEvidence Level
Early surgeryBetter outcomesHigh
AgeYounger = higher perforation riskHigh
PerforationWorse outcomesHigh
Time to surgeryLonger = worseModerate

10. Evidence & Guidelines

Key Guidelines

1. NICE Guidelines (2020) — Appendicitis: diagnosis and management. National Institute for Health and Care Excellence

Key Recommendations:

  • Clinical diagnosis
  • Ultrasound first-line in children
  • Urgent surgery
  • Evidence Level: 1A

Landmark Trials

Multiple studies on laparoscopic vs open, timing of surgery.

Evidence Strength

InterventionLevelKey EvidenceClinical Recommendation
Urgent surgery1AUniversalEssential
Laparoscopic1AMultiple studiesPreferred
Antibiotics pre-op1AMultiple studiesStandard

11. Patient/Layperson Explanation

What is Appendicitis?

Appendicitis is inflammation of the appendix, a small pouch attached to the large intestine. Think of the appendix as a small, dead-end tube—when it gets blocked, bacteria multiply inside, causing inflammation, swelling, and eventually rupture if not treated. Appendicitis is the most common reason children need emergency surgery.

In simple terms: Your child's appendix (a small pouch in the tummy) has become inflamed and infected. It needs to be removed with surgery to prevent it from bursting and causing serious infection.

Why does it matter?

Appendicitis can be serious if not treated promptly. If the appendix bursts (perforates), it can cause a serious infection in the tummy (peritonitis). The good news? With prompt surgery, most children recover completely and quickly.

Think of it like this: It's like a small pouch in the tummy getting infected—it needs to be removed before it bursts and causes more serious problems.

How is it treated?

1. Diagnosis:

  • Examination: Your doctor will examine your child's tummy
  • Tests: Blood tests and sometimes an ultrasound to confirm
  • Why: To make sure it's appendicitis

2. Preparation for Surgery:

  • IV fluids: Your child will get fluids through a drip (if needed)
  • Antibiotics: Your child will get antibiotics to prevent infection
  • Pain relief: Your child will get medicine for pain
  • Nothing to eat/drink: Your child won't be able to eat or drink before surgery

3. Surgery:

  • What: The surgeon will remove the appendix (usually through small cuts using a camera - laparoscopic)
  • When: Usually within a few hours of diagnosis
  • Why: To remove the infected appendix before it bursts
  • Duration: Usually 30-60 minutes

4. After Surgery:

  • Recovery: Your child will recover in hospital
  • Antibiotics: May continue antibiotics if the appendix had burst
  • Going home: Usually within 1-2 days (longer if it had burst)

The goal: Remove the infected appendix quickly to prevent it from bursting and causing more serious problems.

What to expect

Recovery:

  • Surgery: Usually within a few hours of diagnosis
  • Hospital stay: Usually 1-2 days (longer if the appendix had burst)
  • Pain: Should improve quickly after surgery
  • Full recovery: Most children are back to normal within 1-2 weeks

After Treatment:

  • Wound: Small cuts that heal quickly
  • Activity: Can return to normal activities within 1-2 weeks
  • Follow-up: Usually not needed unless complications

Recovery Time:

  • Simple appendicitis: Usually 1-2 days in hospital, back to normal within 1-2 weeks
  • If it had burst: Usually 3-5 days in hospital, may take longer to recover

When to seek help

Call 999 (or your emergency number) immediately if:

  • Your child has severe tummy pain
  • Your child has a high fever and is very unwell
  • Your child's tummy is very tender or hard
  • Your child is very unwell

See your doctor if:

  • Your child has tummy pain that's getting worse
  • Your child has a fever and tummy pain
  • Your child is vomiting and has tummy pain
  • You're concerned about your child

Remember: If your child has tummy pain, especially if it's getting worse, has a fever, or they're vomiting, see your doctor. Appendicitis is common and usually easy to treat if caught early, but it can be serious if the appendix bursts.


12. References

Primary Guidelines

  1. National Institute for Health and Care Excellence. Appendicitis: diagnosis and management. NICE guideline [NG127]. 2020.

Key Trials

  1. Multiple studies on laparoscopic vs open appendicectomy, timing of surgery.

Further Resources

  • NICE Guidelines: National Institute for Health and Care Excellence

Last Reviewed: 2025-12-25 | MedVellum Editorial Team


Medical Disclaimer: MedVellum content is for educational purposes and clinical reference. Clinical decisions should account for individual patient circumstances. Always consult appropriate specialists. This information is not a substitute for professional medical advice, diagnosis, or treatment.

Last updated: 2025-12-25

At a Glance

EvidenceHigh
Last Updated2025-12-25
Emergency Protocol

Red Flags

  • Signs of perforation (severe pain, peritonism)
  • Signs of sepsis
  • Severe dehydration
  • Altered mental status
  • Signs of shock

Clinical Pearls

  • **"Don't delay surgery"** — Once appendicitis is diagnosed, surgery should be done promptly to prevent rupture. Delayed surgery increases the risk of perforation and complications.
  • **Red Flags — Immediate Escalation Required:**
  • - **Signs of perforation (severe pain, peritonism)** — Medical emergency, needs urgent surgery
  • - **Signs of sepsis** — Medical emergency, needs urgent treatment
  • - **Severe dehydration** — Needs IV fluids

Guidelines

  • NICE Guidelines
  • BTS Guidelines
  • RCUK Guidelines