Overview
Allergic Rhinitis
Quick Reference
Critical Alerts
- Allergic rhinitis is not an emergency but commonly presents to ED
- Rule out other causes: Sinusitis, URI, foreign body
- Intranasal corticosteroids are most effective: For persistent symptoms
- Second-generation antihistamines are first-line: Less sedating
- Watch for asthma comorbidity: 40% of allergic rhinitis patients have asthma
- Refer to allergist for severe or refractory cases
Key Features
| Feature | Allergic Rhinitis |
|---|---|
| Nasal congestion | Bilateral |
| Rhinorrhea | Clear, watery |
| Sneezing | Paroxysmal |
| Pruritus | Nose, eyes, palate |
| Eye symptoms | Watery, itchy (allergic conjunctivitis) |
| Triggers | Pollen, dust, pet dander |
Emergency Treatments
| Intervention | Details |
|---|---|
| Intranasal corticosteroid | Fluticasone, mometasone |
| Oral antihistamine | Cetirizine, loratadine, fexofenadine |
| Intranasal antihistamine | Azelastine |
| Decongestant | Pseudoephedrine (short-term) |
| Allergen avoidance | Key preventive measure |
Definition
Overview
Allergic rhinitis is IgE-mediated inflammation of the nasal mucosa in response to inhaled allergens. It is characterized by nasal congestion, rhinorrhea, sneezing, and pruritus. While not a medical emergency, patients may present to the ED seeking symptom relief or when symptoms overlap with other conditions (sinusitis, asthma exacerbation).
Classification
By Timing:
| Type | Features |
|---|---|
| Seasonal (hay fever) | Pollen (spring, fall) |
| Perennial | Year-round (dust mites, pet dander, mold) |
By Severity (ARIA Classification):
| Severity | Features |
|---|---|
| Intermittent | <4 days/week or <4 weeks |
| Persistent | >4 days/week and > weeks |
| Mild | No impairment of sleep, daily activities, work/school |
| Moderate-Severe | Impairment of above |
Epidemiology
- Prevalence: 10-30% of adults
- Most common allergic condition
- Peak onset: Childhood to young adulthood
- Strong association with asthma, eczema, allergic conjunctivitis
Etiology
Common Allergens:
| Type | Examples |
|---|---|
| Seasonal | Tree pollen, grass, ragweed |
| Perennial | Dust mites, pet dander, mold, cockroach |
Risk Factors:
| Factor | Notes |
|---|---|
| Family history | Atopy |
| Eczema | Atopic march |
| Asthma | Comorbid |
Pathophysiology
Mechanism
- Allergen exposure: Inhalation
- IgE sensitization: First exposure → IgE production
- Re-exposure: Allergen cross-links IgE on mast cells
- Mast cell degranulation: Histamine, leukotrienes release
- Early-phase response: Sneezing, rhinorrhea, pruritus (minutes)
- Late-phase response: Nasal congestion (hours)
Clinical Presentation
Symptoms
| Symptom | Description |
|---|---|
| Nasal congestion | Bilateral, variable |
| Rhinorrhea | Clear, watery |
| Sneezing | Paroxysmal |
| Nasal/Palatal pruritus | Itchy nose, roof of mouth |
| Post-nasal drip | Throat clearing |
| Eye symptoms | Watery, itchy, red (allergic conjunctivitis) |
| Seasonal pattern | Worsens with pollen exposure |
History
Key Questions:
Physical Examination
| Finding | Description |
|---|---|
| Allergic shiners | Dark circles under eyes |
| Allergic salute | Nasal crease from rubbing |
| Pale, boggy turbinates | Swollen nasal mucosa |
| Clear rhinorrhea | Watery discharge |
| Cobblestoning pharynx | Post-nasal drip |
| Conjunctival injection | If allergic conjunctivitis |
Symptom timing (seasonal vs year-round)
Common presentation.
Triggers (pollen, pets, dust)
Common presentation.
Eye symptoms
Common presentation.
Prior diagnosis of allergies, asthma, eczema
Common presentation.
Family history of atopy
Common presentation.
Current medications
Common presentation.
Interference with sleep or daily activities
Common presentation.
Red Flags
Exclude Other Diagnoses
| Finding | Concern | Action |
|---|---|---|
| Unilateral symptoms | Foreign body, polyp, tumor | Imaging |
| Purulent discharge | Sinusitis | Treat as indicated |
| Fever | Infection | Rule out sinusitis |
| Epistaxis | Coagulopathy, trauma | Evaluate |
| Wheezing, dyspnea | Asthma | Treat asthma |
Differential Diagnosis
Other Causes of Nasal Symptoms
| Diagnosis | Features |
|---|---|
| Viral URI | Fever, systemic symptoms, self-limited |
| Acute sinusitis | Purulent discharge, facial pain |
| Non-allergic rhinitis | No allergen trigger, no IgE |
| Vasomotor rhinitis | Triggered by temperature, odors |
| Rhinitis medicamentosa | Overuse of decongestant sprays |
| Nasal polyps | Chronic congestion, anosmia |
| Foreign body | Unilateral, foul discharge (children) |
Diagnostic Approach
Clinical Diagnosis
- Allergic rhinitis is a clinical diagnosis
- Based on history and exam
Testing (Usually Outpatient)
| Test | Indication |
|---|---|
| Skin prick testing | Confirm allergens |
| Serum-specific IgE | Alternative to skin testing |
Laboratory
- Not routinely needed in ED
Treatment
Principles
- Allergen avoidance: Primary prevention
- Pharmacotherapy: Based on symptom severity
- Combination therapy for moderate-severe
- Immunotherapy for refractory: Outpatient
First-Line: Intranasal Corticosteroids
Most Effective for Persistent Symptoms:
| Agent | Dose |
|---|---|
| Fluticasone | 1-2 sprays each nostril daily |
| Mometasone | 1-2 sprays each nostril daily |
| Budesonide | 1-2 sprays each nostril daily |
Onset: 12 hours to full effect in 1-2 weeks
Second-Line: Oral Antihistamines
Second-Generation (Preferred—Less Sedating):
| Agent | Dose |
|---|---|
| Cetirizine | 10 mg daily |
| Loratadine | 10 mg daily |
| Fexofenadine | 180 mg daily |
First-Generation (More Sedating):
| Agent | Dose |
|---|---|
| Diphenhydramine | 25-50 mg q6h |
| Chlorpheniramine | 4 mg q4-6h |
Additional Therapies
Intranasal Antihistamine:
| Agent | Dose |
|---|---|
| Azelastine | 1-2 sprays each nostril BID |
Decongestants (Short-Term Only):
| Agent | Dose | Notes |
|---|---|---|
| Pseudoephedrine | 60 mg q4-6h | Max 3-5 days for topical |
| Oxymetazoline nasal | 2-3 sprays q12h | Avoid > days (rebound) |
Leukotriene Receptor Antagonist:
| Agent | Dose |
|---|---|
| Montelukast | 10 mg daily |
Eye Symptoms (Allergic Conjunctivitis):
| Agent | Dose |
|---|---|
| Olopatadine | 1 drop each eye BID |
| Ketotifen | 1 drop each eye BID |
Allergen Avoidance
| Allergen | Measures |
|---|---|
| Dust mites | Encase mattress, wash bedding, reduce humidity |
| Pet dander | Remove pets, HEPA filters |
| Pollen | Close windows, shower after outdoors |
| Mold | Fix leaks, reduce humidity |
Disposition
Discharge Criteria
- Symptoms controlled
- Medications prescribed
- Follow-up arranged
Admission Criteria
- Not typically indicated for allergic rhinitis
Referral
| Indication | Referral |
|---|---|
| Refractory symptoms | Allergist |
| Need for immunotherapy | Allergist |
| Comorbid asthma | Pulmonology/Allergy |
Patient Education
Condition Explanation
- "You have allergies that cause inflammation in your nose."
- "The best treatment is a steroid nasal spray, which works over a few days."
- "Avoiding your triggers (pollen, dust, pets) can help."
Home Care
- Use nasal spray daily for best effect
- Take antihistamines as directed
- Avoid known triggers
- Shower and change clothes after outdoor activities (for pollen)
- Use HEPA air filters
Warning Signs to Return
- Symptoms not improving after 1-2 weeks
- Facial pain, fever (sinusitis)
- Wheezing or difficulty breathing
- Any sign of severe allergic reaction
Special Populations
Pregnancy
- Intranasal corticosteroids (budesonide) safe
- Second-gen antihistamines generally safe (cetirizine, loratadine)
- Avoid decongestants (pseudoephedrine) especially in first trimester
Children
- Intranasal steroids safe
- Second-gen antihistamines preferred
- Rule out foreign body in unilateral symptoms
Elderly
- Avoid first-gen antihistamines (sedation, anticholinergic effects)
- Be cautious with decongestants (HTN, BPH)
Quality Metrics
Performance Indicators
| Metric | Target | Rationale |
|---|---|---|
| Intranasal steroid prescribed for moderate-severe | >0% | Most effective |
| Second-gen antihistamine over first-gen | >0% | Less sedation |
| Decongestant limited to short course | 100% | Avoid rebound |
Documentation Requirements
- Symptom pattern (seasonal vs perennial)
- Trigger identification
- Comorbid asthma
- Treatment and follow-up
Key Clinical Pearls
Diagnostic Pearls
- Itching = Allergy: Pruritus is key feature
- Clear watery rhinorrhea: Vs purulent in sinusitis
- Bilateral and seasonal: Classic pattern
- Allergic shiners and salute: Physical exam clues
- Rule out sinusitis if fever or purulent discharge
- Unilateral symptoms warrant further workup
Treatment Pearls
- Intranasal steroids are most effective: For persistent symptoms
- Second-gen antihistamines are first-line: Less sedating
- Decongestants for short-term only: Rebound congestion
- Combination therapy for moderate-severe
- Allergen avoidance is cornerstone: Prevention
- Leukotriene antagonists useful in asthma comorbidity
Disposition Pearls
- Allergic rhinitis rarely needs admission
- Refer refractory cases to allergist: Immunotherapy
- Screen for and treat comorbid asthma
- Educate on long-term use of intranasal steroids
References
- Brozek JL, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. J Allergy Clin Immunol. 2017;140(4):1099-1143.
- Wheatley LM, Togias A. Allergic rhinitis. N Engl J Med. 2015;372(5):456-463.
- Seidman MD, et al. Clinical practice guideline: Allergic rhinitis. Otolaryngol Head Neck Surg. 2015;152(1 Suppl):S1-S43.
- Wallace DV, et al. The diagnosis and management of rhinitis: An updated practice parameter. J Allergy Clin Immunol. 2008;122(2 Suppl):S1-S84.
- Dykewicz MS, et al. Treatment of seasonal allergic rhinitis: An evidence-based guideline. Ann Allergy Asthma Immunol. 2017;119(6):489-511.
- Greiner AN, et al. Allergic rhinitis. Lancet. 2011;378(9809):2112-2122.
- ARIA Guidelines. Allergic rhinitis and its impact on asthma. 2020.
- UpToDate. Pharmacotherapy of allergic rhinitis. 2024.