Eating Disorders
Summary
Eating disorders are serious mental health conditions characterised by abnormal eating behaviours, distorted body image, and significant physical and psychological consequences. The main types are Anorexia Nervosa (AN) – Restriction, Low BMI, Fear of weight gain; Bulimia Nervosa (BN) – Binge-Purge cycles; and Binge Eating Disorder (BED) – Bingeing without compensatory behaviours. Other categories include OSFED (Other Specified Feeding or Eating Disorder) and ARFID (Avoidant/Restrictive Food Intake Disorder). Anorexia Nervosa has the highest mortality rate of any psychiatric disorder (~10%). Medical complications include electrolyte disturbances (Hypokalaemia, Hyponatraemia), cardiac arrhythmias, osteoporosis, and Refeeding Syndrome (Phosphate depletion during nutritional rehabilitation – Can be fatal). Management involves a multidisciplinary approach: Psychological therapies (CBT-ED, MANTRA, SSCM), nutritional rehabilitation, and monitoring for medical complications. NICE NG69 provides comprehensive guidance.
Key Facts
- Anorexia Nervosa (AN): Restriction, Low BMI (<17.5), Intense fear of weight gain, Distorted body image.
- Bulimia Nervosa (BN): Recurrent binge eating + Compensatory behaviours (Purging, Laxatives, Exercise). Normal/Overweight BMI.
- Binge Eating Disorder (BED): Bingeing without compensatory behaviours. Often obese.
- Mortality: AN = Highest mortality of psychiatric disorders (~10%).
- Refeeding Syndrome: Risk in severely malnourished. Monitor Phosphate.
- Treatment: CBT-ED (BN, BED). MANTRA, CBT-ED, SSCM (AN). Fluoxetine (BN).
Clinical Pearls
"Anorexia Kills": Highest mortality of any psychiatric disorder. Physical monitoring is essential.
"Hypokalaemia in a Young Woman = Consider Bulimia": Purging (Vomiting, Laxatives) causes electrolyte disturbance.
"Refeeding Syndrome – Check Phosphate": When refeeding, phosphate drops rapidly. Can cause cardiac arrest.
"BMI Alone Doesn't Tell the Story": Rate of weight loss, medical complications, and psychological state are equally important.
Why This Matters Clinically
Eating disorders are common, serious, and often hidden. Early recognition and appropriate referral saves lives.
Incidence
| Disorder | Prevalence | Sex Ratio |
|---|---|---|
| Anorexia Nervosa | ~0.3-1% (Lifetime). | F:M = 10:1 (Increasing in males). |
| Bulimia Nervosa | ~1-3% (Lifetime). | F:M = 10:1. |
| Binge Eating Disorder | ~2-3% (Lifetime). Most common ED. | F:M = 3:2 (More balanced). |
- Age of Onset: Often adolescence/early adulthood. Peak 14-19 years.
- Increasing in: Males, Older adults, Ethnic minorities (Previously under-recognised).
Risk Factors
| Factor | Notes |
|---|---|
| Female Sex | |
| Adolescence | Pubertal changes. |
| Dieting | Common precursor. |
| Family History | Genetic component. |
| Personality Traits | Perfectionism, Obsessionality, Low self-esteem. |
| Trauma / Abuse | Childhood sexual abuse (Bulimia). |
| Sports / Occupations | Ballet, Gymnastics, Modelling. |
| Social/Cultural Pressure | Thin ideal. |
| Comorbid Anxiety / Depression |
Anorexia Nervosa (AN)
| Feature | Description |
|---|---|
| Restriction of Energy Intake | Leads to significantly low body weight. |
| Low Body Weight | BMI <18.5 (Mild), <17 (Moderate), <16 (Severe), <15 (Extreme). |
| Intense Fear of Weight Gain | Or persistent behaviour preventing weight gain. |
| Disturbance in Body Perception | Distorted body image. Undue influence of weight on self-evaluation. Lack of recognition of seriousness. |
| Subtypes | Restricting Type vs Binge-Eating/Purging Type. |
Bulimia Nervosa (BN)
| Feature | Description |
|---|---|
| Recurrent Binge Eating | Large amount of food in a short time. Sense of loss of control. |
| Recurrent Compensatory Behaviours | Vomiting, Laxatives, Diuretics, Fasting, Excessive Exercise. |
| Frequency | At least once/week for 3 months (DSM-5). |
| Self-Evaluation | Unduly influenced by body shape/weight. |
| BMI | Usually normal or overweight. |
Binge Eating Disorder (BED)
| Feature | Description |
|---|---|
| Recurrent Binge Eating | Large amount. Loss of control. |
| Associated Features | Eating rapidly. Eating until uncomfortably full. Eating alone (Embarrassment). Disgust/Guilt after. |
| No Compensatory Behaviours | Distinguishes from Bulimia. |
| Frequency | At least once/week for 3 months. |
| BMI | Often overweight/obese. |
Other Specified Feeding or Eating Disorder (OSFED)
- Does not meet full criteria for AN, BN, or BED but clinically significant.
- E.g., Atypical AN (Normal weight AN), Subthreshold BN/BED.
Avoidant/Restrictive Food Intake Disorder (ARFID)
- Avoidance/Restriction of food intake.
- NOT due to body image concerns.
- Leads to nutritional deficiency, Weight loss, Psychosocial impairment.
- E.g., Sensory sensitivity, Fear of choking.
Symptoms (By Disorder)
| Symptom | AN | BN | BED |
|---|---|---|---|
| Restriction | +++ | + | - |
| Low BMI | +++ | - | - |
| Bingeing | + (Subtype) | +++ | +++ |
| Purging (Vomiting, Laxatives) | + (Subtype) | +++ | - |
| Excessive Exercise | ++ | ++ | - |
| Fear of Weight Gain | +++ | +++ | - |
| Body Image Disturbance | +++ | +++ | ++ |
Physical Signs
| Sign | Underlying Cause |
|---|---|
| Low BMI / Cachexia | AN. |
| Lanugo Hair | Downy hair on face/body (AN). |
| Russell's Sign | Calluses on knuckles from self-induced vomiting (BN). |
| Parotid Swelling / "Chipmunk Cheeks" | Purging (BN). |
| Dental Erosion | Gastric acid from vomiting (BN). |
| Bradycardia | AN. <60 bpm. Concerning if <50. |
| Hypotension | AN. |
| Hypothermia | AN. |
| Oedema | Hypoalbuminaemia (AN). Refeeding. |
| Muscle Wasting | AN. |
Psychological Features
Medical Complications
| System | Complication |
|---|---|
| Cardiovascular | Bradycardia. Hypotension. Arrhythmias (QTc prolongation). Sudden cardiac death. |
| Electrolytes | Hypokalaemia (Purging). Hyponatraemia. Hypophosphataemia (Refeeding). |
| GI | Constipation. Delayed gastric emptying. Pancreatitis (Refeeding). |
| Endocrine | Amenorrhoea. Hypothyroidism (Sick euthyroid). Hypercortisolism. |
| Bone | Osteopenia. Osteoporosis. Fractures. |
| Haematological | Anaemia. Leucopenia. Thrombocytopenia. |
| Renal | AKI. Chronic kidney disease (Laxative abuse). |
| Neurological | Cerebral atrophy (Reversible). Seizures. |
| Dental | Erosion (BN). Caries. |
| Dermatological | Dry skin. Lanugo. Hair loss. |
Refeeding Syndrome
| Feature | Notes |
|---|---|
| Definition | Shift from catabolic to anabolic state causes rapid intracellular electrolyte shifts. |
| Key Electrolyte | Hypophosphataemia. Also Hypokalaemia, Hypomagnesaemia. |
| Risk Factors | BMI <16, Little/No intake for >0 days, Low baseline Phosphate/K+/Mg++. |
| Complications | Cardiac arrhythmias. Heart failure. Respiratory failure. Seizures. Death. |
| Prevention | Start feeding slowly ("Start low, Go slow"). Monitor electrolytes. Prophylactic Thiamine, Phosphate, Potassium. |
Physical Assessment
| Test | Purpose |
|---|---|
| Weight, Height, BMI | Baseline. Trend. |
| Orthostatic Vital Signs | Postural hypotension. |
| Heart Rate | Bradycardia <60. |
| Temperature | Hypothermia. |
Blood Tests
| Test | Abnormality |
|---|---|
| FBC | Anaemia. Leucopenia. Thrombocytopenia. |
| U&E | Hypokalaemia (Purging). Hyponatraemia. AKI. |
| Phosphate, Magnesium, Calcium | Baseline for refeeding. |
| LFTs | Elevated in starvation. |
| Glucose | Hypoglycaemia. |
| TFTs | Sick euthyroid (Low T3). |
| Bone Profile / Vitamin D |
ECG
- Bradycardia.
- QTc Prolongation (Risk of Torsades – Hypokalaemia).
- ST/T changes.
DEXA
- Bone density if prolonged amenorrhoea or low weight.
Principles
- Multidisciplinary Team (Psychiatry, Dietitian, Physician, Nursing).
- Psychological Therapy (Core treatment).
- Nutritional Rehabilitation (Weight restoration in AN).
- Medical Monitoring (Bloods, ECG, Refeeding syndrome prevention).
- Treat Comorbidities (Depression, Anxiety).
- Medication (Adjunctive, Not first-line for AN).
Psychological Therapies (Per NICE NG69)
| Disorder | Therapy | Notes |
|---|---|---|
| Anorexia Nervosa (Adults) | MANTRA (Maudsley Model of AN Treatment for Adults). CBT-ED. SSCM (Specialist Supportive Clinical Management). | Family therapy for adolescents. |
| Bulimia Nervosa | CBT-ED (First-line). Guided self-help. | Fluoxetine 60mg (Adjunct). |
| Binge Eating Disorder | CBT-ED (First-line). Guided self-help. | Topiramate (Off-label, Limited). Lisdexamfetamine (USA). |
Nutritional Rehabilitation (AN)
| Approach | Notes |
|---|---|
| Outpatient | Mild AN. Medically stable. |
| Day Patient | Moderate. Structured meals. |
| Inpatient (Specialist Unit) | Severe AN. BMI <15 or high risk. Medical instability. Failed outpatient. |
| Refeeding Protocol | Start low (e.g., 1200 kcal/day) and increase slowly. Monitor bloods. Thiamine/Phosphate supplementation. |
Medications
| Drug | Indication | Notes |
|---|---|---|
| Fluoxetine 60mg OD | Bulimia Nervosa. | Reduces binge-purge frequency. Not for AN. |
| Lisdexamfetamine | Binge Eating Disorder (USA). | Not routinely UK. |
| Olanzapine | Severe AN (refractory). | May reduce weight preoccupation (Limited evidence). |
| SSRIs | Comorbid Depression/Anxiety. | Not effective for core AN symptoms. |
Admission Criteria (MARSIPAN – High Risk)
| Indicator | Notes |
|---|---|
| BMI <13 (or Rapid decline) | High risk. |
| Heart Rate <40 bpm | |
| Systolic BP <90 mmHg | |
| Postural Hypotension | Pulse rise >20, SBP drop >0. |
| Significant Electrolyte Disturbance | |
| Temperature <35.5°C | |
| QTc Prolongation >50ms | |
| Hypoglycaemia | |
| Acute Suicidal Risk |
| Disorder | Prognosis |
|---|---|
| Anorexia Nervosa | ~50% Full recovery. ~30% Partial recovery. ~20% Chronic/Deceased. Mortality ~10% (Highest of any psychiatric disorder). |
| Bulimia Nervosa | ~50-70% Recovery with treatment. |
| Binge Eating Disorder | Generally good with treatment. |
Mortality Causes (AN)
- Sudden Cardiac Death (Arrhythmias).
- Suicide.
- Infection.
Key Guidelines
| Guideline | Organisation | Notes |
|---|---|---|
| NICE NG69 | NICE | Eating Disorders: Recognition and Treatment. |
| MARSIPAN (Medical Emergencies in AN) | RCPsych / RCP | Risk assessment. Admission criteria. |
| Junior MARSIPAN | RCPsych | For under-18s. |
Scenario 1:
- Stem: A 17-year-old girl presents with 6 months of weight loss, BMI 15.5, and fear of weight gain. She restricts her food intake. What is the diagnosis and first-line treatment?
- Answer: Anorexia Nervosa (Restricting Type). First-line treatment: Family-based treatment (FBT) for adolescents. (Adults: MANTRA, CBT-ED, or SSCM).
Scenario 2:
- Stem: A young woman with Bulimia Nervosa is found to have Hypokalaemia and QTc prolongation. What is the cause?
- Answer: Electrolyte disturbance from Purging (Vomiting/Laxatives). Risk of cardiac arrhythmias.
Scenario 3:
- Stem: What is the key electrolyte to monitor when refeeding a malnourished patient?
- Answer: Phosphate. Refeeding syndrome causes severe Hypophosphataemia.
| Scenario | Urgency | Action |
|---|---|---|
| Suspected Eating Disorder | Urgent | GP + Eating Disorder Service referral. |
| BMI <15 or Rapid Weight Loss | Urgent | Specialist Eating Disorder Service or Medical assessment. |
| Medical Instability (Bradycardia, Hypokalaemia, QTc prolongation) | Emergency | Admit (Medical +/- Psychiatric). |
| Suicidal Ideation | Emergency | Psychiatric assessment. |
What are Eating Disorders?
Eating disorders are serious mental health conditions where people have an unhealthy relationship with food and their body. They include:
- Anorexia: Extreme restriction of food. Very low weight.
- Bulimia: Binge eating followed by purging (vomiting, laxatives).
- Binge Eating Disorder: Eating large amounts without purging.
Why are they serious?
Eating disorders can cause serious health problems: Heart problems, Weak bones, Kidney damage, and can be fatal. Anorexia has the highest death rate of any mental illness.
How are they treated?
- Psychological therapy: Talking therapies like CBT.
- Nutritional support: Helping to restore healthy eating.
- Medical monitoring: Checking heart, blood tests.
- Sometimes medication: Especially for Bulimia.
Key Counselling Points
- Recovery is Possible: "With the right treatment, many people make a full recovery."
- Seek Help Early: "The sooner treatment starts, the better the outcome."
- Support is Available: "Organisations like BEAT (UK) offer help for patients and families."
| Standard | Target |
|---|---|
| Physical assessment (Weight, HR, BP, Bloods) at first presentation | 100% |
| ECG if low BMI or electrolyte disturbance | 100% |
| Specialist Eating Disorder Service referral | >5% |
| Refeeding protocol followed for high-risk patients | 100% |
- Sir William Gull (1868): First described Anorexia Nervosa ("Apepsia Hysterica").
- Gerald Russell (1979): Described Bulimia Nervosa as a distinct entity.
- Binge Eating Disorder: Added to DSM-5 (2013).
- NICE NG69. Eating Disorders: Recognition and Treatment. 2017. nice.org.uk
- MARSIPAN. Management of Really Sick Patients with Anorexia Nervosa. RCPsych. rcpsych.ac.uk
Last Reviewed: 2025-12-24 | MedVellum Editorial Team
Medical Disclaimer: MedVellum content is for educational purposes and clinical reference. If you or someone you know is struggling with an eating disorder, please seek help.