Insomnia
Summary
Insomnia is a sleep disorder characterised by persistent difficulty with sleep initiation, maintenance, consolidation, or quality despite adequate opportunity for sleep, resulting in daytime impairment (Fatigue, Poor concentration, Mood disturbance). Chronic Insomnia Disorder is defined as symptoms occurring ≥3 nights per week for ≥3 months. Insomnia is extremely common, affecting ~10% of adults chronically. It is often comorbid with psychiatric conditions (Depression, Anxiety), medical conditions (Chronic pain, COPD, Heart failure), and other sleep disorders (OSA). First-line treatment is Cognitive Behavioural Therapy for Insomnia (CBT-I), which is highly effective and has durable effects. Pharmacotherapy (Z-drugs, Short-acting Benzodiazepines) should be reserved for short-term use when CBT-I is unavailable or ineffective. Melatonin may be considered in patients ≥55 years. Long-term hypnotic use is discouraged due to dependence, tolerance, and adverse effects. [1,2]
Clinical Pearls
CBT-I is First-Line: Cognitive Behavioural Therapy for Insomnia is more effective than medication in the long term and should be offered first.
"3-3 Rule" for Chronic Insomnia: ≥3 nights per week for ≥3 months.
Don't Prescribe Long-Term Hypnotics: Z-drugs and Benzodiazepines are for short-term use only (2-4 weeks). Risk of dependence, next-day sedation, falls.
Always Screen for Comorbidities: Depression, Anxiety, Sleep Apnoea, Restless Legs, Chronic Pain, Substance use.
Prevalence
- Very Common: 10-15% of adults have Chronic Insomnia. Up to 30-40% have occasional insomnia symptoms.
- Sex: Female > Male (1.5:1). Increases after menopause.
- Age: Increases with age.
Comorbidities (Frequently Associated)
| Condition | Notes |
|---|---|
| Depression | Bidirectional relationship. Insomnia is a symptom of Depression AND a risk factor for Depression. |
| Anxiety Disorders | Common. Racing thoughts at night. |
| Chronic Pain | Fibromyalgia, Arthritis. Pain disrupts sleep. |
| Obstructive Sleep Apnoea (OSA) | Co-insomnia + OSA common. OSA must be excluded if symptoms suggest. |
| Restless Legs Syndrome (RLS) | Urge to move legs, worse at rest. Delays sleep onset. |
| Substance Use | Alcohol (Disrupts sleep architecture), Caffeine, Stimulants. |
| Medical Conditions | Heart Failure (Orthopnoea), COPD, GORD, Nocturia. |
Spielman's 3P Model
- Predisposing Factors: Genetic vulnerability, Hyperarousal, Personality traits (Rumination, Perfectionism).
- Precipitating Factors: Stressful life event, Illness, Pain, Change in schedule.
- Perpetuating Factors: Maladaptive behaviours (Spending too long in bed, Daytime napping, Clock-watching), Dysfunctional beliefs about sleep, Caffeine/Alcohol.
Hyperarousal Model
- Chronic insomnia is associated with physiological and cognitive hyperarousal (Elevated cortisol, Increased heart rate, Racing thoughts).
| Condition | Key Features |
|---|---|
| Primary (Chronic) Insomnia | Difficulty initiating/maintaining sleep. Daytime impairment. ≥3 nights/week x ≥3 months. No other cause. |
| Depression-Related Insomnia | Early morning waking (Typical). Low mood, Anhedonia. Treat Depression first. |
| Anxiety-Related Insomnia | Difficulty initiating sleep. Racing thoughts. Anxiety symptoms. |
| Obstructive Sleep Apnoea (OSA) | Snoring, Witnessed apnoeas, Daytime sleepiness (May have insomnia too). Refer for Sleep Study. |
| Restless Legs Syndrome | Urge to move legs at rest/evening. Delays sleep onset. Ferritin may be low. |
| Circadian Rhythm Disorder | Delayed Sleep Phase (Night owls). Advanced Sleep Phase (Elderly). Shift work. |
| Substance-Induced | Caffeine, Alcohol, Stimulants, Medication (Steroids, Beta-blockers). |
| Medical Condition | Pain, Nocturia, GORD, Menopause. |
Types of Insomnia
| Type | Description |
|---|---|
| Sleep Onset Insomnia | Difficulty falling asleep (>30 mins to fall asleep). Racing mind. |
| Sleep Maintenance Insomnia | Difficulty staying asleep. Frequent awakenings. Waking too early. |
| Early Morning Awakening | Waking before desired time, Unable to return to sleep. Classic for Depression. |
| Mixed | Combination of above. |
Daytime Consequences (Required for Diagnosis)
| Symptom | Notes |
|---|---|
| Fatigue / Tiredness | Not refreshed by sleep. |
| Poor Concentration / Memory | Cognitive impairment. |
| Mood Disturbance | Irritability, Dysphoria. |
| Daytime Sleepiness | May be present (But if excessive, consider OSA). |
| Reduced Motivation / Energy | |
| Impaired Work / Social Functioning |
History Taking
Clinical Diagnosis (Usually No Tests Needed)
- Insomnia is diagnosed clinically based on history.
Consider When Indicated
| Investigation | Indication |
|---|---|
| Sleep Diary (2 Weeks) | Essential. Document bedtime, Wake time, Time to fall asleep, Awakenings. Identifies patterns. |
| Actigraphy | Wrist-worn device. Objective sleep-wake data. Useful for Circadian disorders. |
| Polysomnography (Sleep Study) | If OSA, Narcolepsy, or other primary sleep disorder suspected. NOT routine for insomnia. |
| Blood Tests (TFTs, Ferritin, HbA1c) | If underlying medical cause suspected (Thyroid, RLS – Low ferritin, Diabetes – Nocturia). |
| Questionnaires | Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS – For excessive daytime sleepiness, suggests OSA), PHQ-9/GAD-7 (Mood). |
Management Algorithm
PATIENT WITH INSOMNIA SYMPTOMS
(Difficulty Initiating/Maintaining Sleep + Daytime Impairment)
↓
ASSESS DURATION & FREQUENCY
(≥3 nights/week x ≥3 months = Chronic Insomnia)
↓
EXCLUDE / TREAT COMORBIDITIES
- Psychiatric: Depression, Anxiety
- Medical: Pain, OSA, RLS, Nocturia
- Substances: Caffeine, Alcohol, Medications
↓
SLEEP HYGIENE EDUCATION (For All)
┌──────────────────────────────────────────────────────────┐
│ - Consistent Bed/Wake Time (Even weekends) │
│ - Avoid Caffeine after Noon │
│ - Limit Alcohol (Disrupts sleep architecture) │
│ - Avoid Screens 1 hour before bed │
│ - Cool, Dark, Quiet bedroom │
│ - Regular Exercise (Not late evening) │
│ - Avoid Heavy Meals/Fluids before bed │
│ - Get out of bed if not asleep in 20 mins │
│ - Avoid Clock-Watching │
│ - Limit Daytime Naps (If needed, less than 30 mins early pm) │
└──────────────────────────────────────────────────────────┘
↓
FIRST-LINE: COGNITIVE BEHAVIOURAL THERAPY FOR INSOMNIA (CBT-I)
┌──────────────────────────────────────────────────────────┐
│ - GOLD STANDARD for Chronic Insomnia. │
│ - 4-8 sessions (Face-to-face, Group, or Digital). │
│ - Components: │
│ - Sleep Restriction Therapy (Limit time in bed) │
│ - Stimulus Control (Bed for sleep/sex only) │
│ - Cognitive Therapy (Challenge dysfunctional beliefs) │
│ - Relaxation Training │
│ - Durable effect (Maintains improvement long-term). │
│ - Digital CBT-I: Sleepio, SHUTi (NICE Approved). │
└──────────────────────────────────────────────────────────┘
↓
CBT-I NOT AVAILABLE OR INADEQUATE RESPONSE?
↓
SHORT-TERM PHARMACOTHERAPY (2-4 Weeks Max)
┌──────────────────────────────────────────────────────────┐
│ Z-DRUGS (Non-Benzodiazepine Hypnotics) │
│ - Zopiclone 3.75-7.5mg Nocte (Short-acting) │
│ - Zolpidem 5-10mg Nocte │
│ - Short-term use ONLY (2-4 weeks). │
│ - Risks: Dependence, Tolerance, Next-day sedation, Falls│
│ │
│ SHORT-ACTING BENZODIAZEPINES │
│ - Temazepam 10-20mg Nocte │
│ - Short-term use ONLY. Similar risks. │
│ │
│ MELATONIN (Circadin – Modified Release) │
│ - Consider in ≥55 years. 2mg 1-2 hours before bed. │
│ - Up to 13 weeks. Lower abuse potential. │
└──────────────────────────────────────────────────────────┘
↓
AVOID LONG-TERM HYPNOTICS
(Risk of Dependence, Falls, Cognitive Impairment)
↓
REFRACTORY INSOMNIA?
- Refer to Sleep Medicine / Psychiatry.
- Consider comorbid Depression/Anxiety.
- Consider Low-Dose Sedating Antidepressant
(Amitriptyline 10-25mg, Mirtazapine 7.5-15mg – Off-label).
CBT-I Components
| Component | Description |
|---|---|
| Sleep Restriction | Limit time in bed to actual sleep time. Increases sleep drive. Gradually extend. |
| Stimulus Control | Bed for sleep and sex only. Get up if awake >20 mins. No reading/screens in bed. |
| Cognitive Therapy | Address unhelpful beliefs about sleep ("I must get 8 hours"). |
| Relaxation Training | Progressive muscle relaxation. Mindfulness. |
| Sleep Hygiene Education | Consistent schedule, Environment, Caffeine/Alcohol. |
Pharmacotherapy (Short-Term Only)
| Agent | Dose | Notes |
|---|---|---|
| Zopiclone | 3.75-7.5mg Nocte | Z-drug. Short-acting. Max 2-4 weeks. Metallic taste side effect. |
| Zolpidem | 5-10mg Nocte | Z-drug. Very short-acting. |
| Temazepam | 10-20mg Nocte | Short-acting Benzodiazepine. |
| Melatonin (Circadin) | 2mg Nocte | For ≥55 years. Modified-release. Up to 13 weeks. |
| Trazodone / Amitriptyline / Mirtazapine | Low dose | Off-label. Sedating antidepressants. May be considered in chronic/refractory or comorbid depression. |
| Complication | Notes |
|---|---|
| Depression / Anxiety | Bidirectional. Insomnia worsens mood. |
| Cognitive Impairment | Poor concentration, Memory. Daytime functioning. |
| Increased Cardiovascular Risk | Chronic sleep deprivation associated with Hypertension, CVD. |
| Falls | Especially with hypnotic use in elderly. |
| Motor Vehicle Accidents | Daytime sleepiness. |
| Substance Misuse | Self-medication with Alcohol, OTC sedatives. |
- CBT-I: Effective in ~70-80%. Durable effect (Maintains improvement years later).
- Pharmacotherapy: Less durable. Symptoms often return on stopping.
- Chronic Course: Many patients have waxing/waning symptoms over years.
- Addressing Comorbidities: Improves outcomes.
Key Guidelines
| Guideline | Organisation | Key Recommendations |
|---|---|---|
| European Guideline for Insomnia (ESRS) | ESRS (2017) | CBT-I first-line. Short-term pharmacotherapy if needed. |
| NICE Guidance | NICE | Sleep hygiene, CBT-I (Digital approved), Short-term hypnotics. |
| ACP Clinical Practice Guideline | ACP | Strong recommendation for CBT-I as first-line. |
What is Insomnia?
Insomnia is difficulty falling asleep, staying asleep, or waking too early, even when you have enough chance to sleep. It makes you feel tired and unable to function well during the day.
What causes it?
Stress, life changes, medical conditions, pain, or mental health issues (like anxiety or depression) can trigger it. Sometimes it becomes a habit – your body "learns" not to sleep well.
How is it treated?
The best treatment is Cognitive Behavioural Therapy for Insomnia (CBT-I). This is a talking therapy that helps change the thoughts and behaviours that keep insomnia going. It is more effective than sleeping tablets in the long run.
Sleep hygiene is also important: keeping a regular schedule, avoiding caffeine/alcohol, limiting screens, and making your bedroom comfortable.
Sleeping tablets (like Zopiclone) are sometimes used for short periods (2-4 weeks), but they are not a long-term solution because they can become addictive and have side effects.
Primary Sources
- Riemann D, et al. European guideline for the diagnosis and treatment of insomnia. J Sleep Res. 2017;26(6):675-700. PMID: 28618182.
- Qaseem A, et al. Management of Chronic Insomnia Disorder in Adults: A Clinical Practice Guideline From the American College of Physicians. Ann Intern Med. 2016;165(2):125-33. PMID: 27136449.
Common Exam Questions
- First-Line Treatment: "What is the first-line treatment for Chronic Insomnia?"
- Answer: Cognitive Behavioural Therapy for Insomnia (CBT-I).
- Definition of Chronic Insomnia: "How is Chronic Insomnia defined?"
- Answer: Symptoms ≥3 nights per week for ≥3 months.
- Why Avoid Long-Term Hypnotics?: "Why are hypnotics not recommended long-term?"
- Answer: Risk of Dependence, Tolerance, Next-day sedation, Falls (Especially in elderly), Cognitive impairment.
- Early Morning Waking: "Early morning awakening is classically associated with which psychiatric condition?"
- Answer: Depression.
Viva Points
- CBT-I Components: Explain Sleep Restriction and Stimulus Control.
- Melatonin: Licensed for ≥55 years in UK.
Medical Disclaimer: MedVellum content is for educational purposes and clinical reference. Clinical decisions should account for individual patient circumstances. Always consult appropriate specialists.