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Psychiatry
Sleep Medicine
General Practice

Insomnia

High EvidenceUpdated: 2025-12-24

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Red Flags

  • Suicidal Ideation (Insomnia is a Risk Factor for Suicide)
  • Substance Misuse (Alcohol, Sedatives)
  • Underlying Obstructive Sleep Apnoea (OSA)
  • Symptoms Suggesting Other Sleep Disorder (Narcolepsy, RLS)
Overview

Insomnia

1. Clinical Overview

Summary

Insomnia is a sleep disorder characterised by persistent difficulty with sleep initiation, maintenance, consolidation, or quality despite adequate opportunity for sleep, resulting in daytime impairment (Fatigue, Poor concentration, Mood disturbance). Chronic Insomnia Disorder is defined as symptoms occurring ≥3 nights per week for ≥3 months. Insomnia is extremely common, affecting ~10% of adults chronically. It is often comorbid with psychiatric conditions (Depression, Anxiety), medical conditions (Chronic pain, COPD, Heart failure), and other sleep disorders (OSA). First-line treatment is Cognitive Behavioural Therapy for Insomnia (CBT-I), which is highly effective and has durable effects. Pharmacotherapy (Z-drugs, Short-acting Benzodiazepines) should be reserved for short-term use when CBT-I is unavailable or ineffective. Melatonin may be considered in patients ≥55 years. Long-term hypnotic use is discouraged due to dependence, tolerance, and adverse effects. [1,2]

Clinical Pearls

CBT-I is First-Line: Cognitive Behavioural Therapy for Insomnia is more effective than medication in the long term and should be offered first.

"3-3 Rule" for Chronic Insomnia: ≥3 nights per week for ≥3 months.

Don't Prescribe Long-Term Hypnotics: Z-drugs and Benzodiazepines are for short-term use only (2-4 weeks). Risk of dependence, next-day sedation, falls.

Always Screen for Comorbidities: Depression, Anxiety, Sleep Apnoea, Restless Legs, Chronic Pain, Substance use.


2. Epidemiology

Prevalence

  • Very Common: 10-15% of adults have Chronic Insomnia. Up to 30-40% have occasional insomnia symptoms.
  • Sex: Female > Male (1.5:1). Increases after menopause.
  • Age: Increases with age.

Comorbidities (Frequently Associated)

ConditionNotes
DepressionBidirectional relationship. Insomnia is a symptom of Depression AND a risk factor for Depression.
Anxiety DisordersCommon. Racing thoughts at night.
Chronic PainFibromyalgia, Arthritis. Pain disrupts sleep.
Obstructive Sleep Apnoea (OSA)Co-insomnia + OSA common. OSA must be excluded if symptoms suggest.
Restless Legs Syndrome (RLS)Urge to move legs, worse at rest. Delays sleep onset.
Substance UseAlcohol (Disrupts sleep architecture), Caffeine, Stimulants.
Medical ConditionsHeart Failure (Orthopnoea), COPD, GORD, Nocturia.

3. Pathophysiology

Spielman's 3P Model

  1. Predisposing Factors: Genetic vulnerability, Hyperarousal, Personality traits (Rumination, Perfectionism).
  2. Precipitating Factors: Stressful life event, Illness, Pain, Change in schedule.
  3. Perpetuating Factors: Maladaptive behaviours (Spending too long in bed, Daytime napping, Clock-watching), Dysfunctional beliefs about sleep, Caffeine/Alcohol.

Hyperarousal Model

  • Chronic insomnia is associated with physiological and cognitive hyperarousal (Elevated cortisol, Increased heart rate, Racing thoughts).

4. Differential Diagnosis
ConditionKey Features
Primary (Chronic) InsomniaDifficulty initiating/maintaining sleep. Daytime impairment. ≥3 nights/week x ≥3 months. No other cause.
Depression-Related InsomniaEarly morning waking (Typical). Low mood, Anhedonia. Treat Depression first.
Anxiety-Related InsomniaDifficulty initiating sleep. Racing thoughts. Anxiety symptoms.
Obstructive Sleep Apnoea (OSA)Snoring, Witnessed apnoeas, Daytime sleepiness (May have insomnia too). Refer for Sleep Study.
Restless Legs SyndromeUrge to move legs at rest/evening. Delays sleep onset. Ferritin may be low.
Circadian Rhythm DisorderDelayed Sleep Phase (Night owls). Advanced Sleep Phase (Elderly). Shift work.
Substance-InducedCaffeine, Alcohol, Stimulants, Medication (Steroids, Beta-blockers).
Medical ConditionPain, Nocturia, GORD, Menopause.

5. Clinical Presentation

Types of Insomnia

TypeDescription
Sleep Onset InsomniaDifficulty falling asleep (>30 mins to fall asleep). Racing mind.
Sleep Maintenance InsomniaDifficulty staying asleep. Frequent awakenings. Waking too early.
Early Morning AwakeningWaking before desired time, Unable to return to sleep. Classic for Depression.
MixedCombination of above.

Daytime Consequences (Required for Diagnosis)

SymptomNotes
Fatigue / TirednessNot refreshed by sleep.
Poor Concentration / MemoryCognitive impairment.
Mood DisturbanceIrritability, Dysphoria.
Daytime SleepinessMay be present (But if excessive, consider OSA).
Reduced Motivation / Energy
Impaired Work / Social Functioning

History Taking


Sleep Schedule
Bedtime, Wake time, Time to fall asleep, Awakenings, Total sleep time.
Sleep Environment
Noise, Light, Temperature, Partner snoring.
Sleep Behaviours
Screen use, Caffeine/Alcohol, Napping, Clock-watching.
Daytime Impact
Fatigue, Concentration, Mood.
Psychiatric Screen
Depression, Anxiety.
Medical History
Pain, Respiratory, Cardiac, Urological.
Drug/Substance History
Caffeine, Alcohol, Medications.
Partner History
Snoring, Apnoeas (OSA), Leg movements (RLS/PLMD).
6. Investigations

Clinical Diagnosis (Usually No Tests Needed)

  • Insomnia is diagnosed clinically based on history.

Consider When Indicated

InvestigationIndication
Sleep Diary (2 Weeks)Essential. Document bedtime, Wake time, Time to fall asleep, Awakenings. Identifies patterns.
ActigraphyWrist-worn device. Objective sleep-wake data. Useful for Circadian disorders.
Polysomnography (Sleep Study)If OSA, Narcolepsy, or other primary sleep disorder suspected. NOT routine for insomnia.
Blood Tests (TFTs, Ferritin, HbA1c)If underlying medical cause suspected (Thyroid, RLS – Low ferritin, Diabetes – Nocturia).
QuestionnairesInsomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS – For excessive daytime sleepiness, suggests OSA), PHQ-9/GAD-7 (Mood).

7. Management

Management Algorithm

       PATIENT WITH INSOMNIA SYMPTOMS
       (Difficulty Initiating/Maintaining Sleep + Daytime Impairment)
                     ↓
       ASSESS DURATION & FREQUENCY
       (≥3 nights/week x ≥3 months = Chronic Insomnia)
                     ↓
       EXCLUDE / TREAT COMORBIDITIES
       - Psychiatric: Depression, Anxiety
       - Medical: Pain, OSA, RLS, Nocturia
       - Substances: Caffeine, Alcohol, Medications
                     ↓
       SLEEP HYGIENE EDUCATION (For All)
    ┌──────────────────────────────────────────────────────────┐
    │  - Consistent Bed/Wake Time (Even weekends)              │
    │  - Avoid Caffeine after Noon                             │
    │  - Limit Alcohol (Disrupts sleep architecture)           │
    │  - Avoid Screens 1 hour before bed                       │
    │  - Cool, Dark, Quiet bedroom                             │
    │  - Regular Exercise (Not late evening)                   │
    │  - Avoid Heavy Meals/Fluids before bed                   │
    │  - Get out of bed if not asleep in 20 mins               │
    │  - Avoid Clock-Watching                                  │
    │  - Limit Daytime Naps (If needed, less than 30 mins early pm)     │
    └──────────────────────────────────────────────────────────┘
                     ↓
       FIRST-LINE: COGNITIVE BEHAVIOURAL THERAPY FOR INSOMNIA (CBT-I)
    ┌──────────────────────────────────────────────────────────┐
    │  - GOLD STANDARD for Chronic Insomnia.                   │
    │  - 4-8 sessions (Face-to-face, Group, or Digital).       │
    │  - Components:                                           │
    │    - Sleep Restriction Therapy (Limit time in bed)       │
    │    - Stimulus Control (Bed for sleep/sex only)           │
    │    - Cognitive Therapy (Challenge dysfunctional beliefs) │
    │    - Relaxation Training                                 │
    │  - Durable effect (Maintains improvement long-term).     │
    │  - Digital CBT-I: Sleepio, SHUTi (NICE Approved).        │
    └──────────────────────────────────────────────────────────┘
                     ↓
       CBT-I NOT AVAILABLE OR INADEQUATE RESPONSE?
                     ↓
       SHORT-TERM PHARMACOTHERAPY (2-4 Weeks Max)
    ┌──────────────────────────────────────────────────────────┐
    │  Z-DRUGS (Non-Benzodiazepine Hypnotics)                 │
    │  - Zopiclone 3.75-7.5mg Nocte (Short-acting)             │
    │  - Zolpidem 5-10mg Nocte                                 │
    │  - Short-term use ONLY (2-4 weeks).                      │
    │  - Risks: Dependence, Tolerance, Next-day sedation, Falls│
    │                                                          │
    │  SHORT-ACTING BENZODIAZEPINES                            │
    │  - Temazepam 10-20mg Nocte                               │
    │  - Short-term use ONLY. Similar risks.                   │
    │                                                          │
    │  MELATONIN (Circadin – Modified Release)                 │
    │  - Consider in ≥55 years. 2mg 1-2 hours before bed.      │
    │  - Up to 13 weeks. Lower abuse potential.                │
    └──────────────────────────────────────────────────────────┘
                     ↓
       AVOID LONG-TERM HYPNOTICS
       (Risk of Dependence, Falls, Cognitive Impairment)
                     ↓
       REFRACTORY INSOMNIA?
       - Refer to Sleep Medicine / Psychiatry.
       - Consider comorbid Depression/Anxiety.
       - Consider Low-Dose Sedating Antidepressant
         (Amitriptyline 10-25mg, Mirtazapine 7.5-15mg – Off-label).

CBT-I Components

ComponentDescription
Sleep RestrictionLimit time in bed to actual sleep time. Increases sleep drive. Gradually extend.
Stimulus ControlBed for sleep and sex only. Get up if awake >20 mins. No reading/screens in bed.
Cognitive TherapyAddress unhelpful beliefs about sleep ("I must get 8 hours").
Relaxation TrainingProgressive muscle relaxation. Mindfulness.
Sleep Hygiene EducationConsistent schedule, Environment, Caffeine/Alcohol.

Pharmacotherapy (Short-Term Only)

AgentDoseNotes
Zopiclone3.75-7.5mg NocteZ-drug. Short-acting. Max 2-4 weeks. Metallic taste side effect.
Zolpidem5-10mg NocteZ-drug. Very short-acting.
Temazepam10-20mg NocteShort-acting Benzodiazepine.
Melatonin (Circadin)2mg NocteFor ≥55 years. Modified-release. Up to 13 weeks.
Trazodone / Amitriptyline / MirtazapineLow doseOff-label. Sedating antidepressants. May be considered in chronic/refractory or comorbid depression.

8. Complications
ComplicationNotes
Depression / AnxietyBidirectional. Insomnia worsens mood.
Cognitive ImpairmentPoor concentration, Memory. Daytime functioning.
Increased Cardiovascular RiskChronic sleep deprivation associated with Hypertension, CVD.
FallsEspecially with hypnotic use in elderly.
Motor Vehicle AccidentsDaytime sleepiness.
Substance MisuseSelf-medication with Alcohol, OTC sedatives.

9. Prognosis and Outcomes
  • CBT-I: Effective in ~70-80%. Durable effect (Maintains improvement years later).
  • Pharmacotherapy: Less durable. Symptoms often return on stopping.
  • Chronic Course: Many patients have waxing/waning symptoms over years.
  • Addressing Comorbidities: Improves outcomes.

10. Evidence and Guidelines

Key Guidelines

GuidelineOrganisationKey Recommendations
European Guideline for Insomnia (ESRS)ESRS (2017)CBT-I first-line. Short-term pharmacotherapy if needed.
NICE GuidanceNICESleep hygiene, CBT-I (Digital approved), Short-term hypnotics.
ACP Clinical Practice GuidelineACPStrong recommendation for CBT-I as first-line.

11. Patient and Layperson Explanation

What is Insomnia?

Insomnia is difficulty falling asleep, staying asleep, or waking too early, even when you have enough chance to sleep. It makes you feel tired and unable to function well during the day.

What causes it?

Stress, life changes, medical conditions, pain, or mental health issues (like anxiety or depression) can trigger it. Sometimes it becomes a habit – your body "learns" not to sleep well.

How is it treated?

The best treatment is Cognitive Behavioural Therapy for Insomnia (CBT-I). This is a talking therapy that helps change the thoughts and behaviours that keep insomnia going. It is more effective than sleeping tablets in the long run.

Sleep hygiene is also important: keeping a regular schedule, avoiding caffeine/alcohol, limiting screens, and making your bedroom comfortable.

Sleeping tablets (like Zopiclone) are sometimes used for short periods (2-4 weeks), but they are not a long-term solution because they can become addictive and have side effects.


12. References

Primary Sources

  1. Riemann D, et al. European guideline for the diagnosis and treatment of insomnia. J Sleep Res. 2017;26(6):675-700. PMID: 28618182.
  2. Qaseem A, et al. Management of Chronic Insomnia Disorder in Adults: A Clinical Practice Guideline From the American College of Physicians. Ann Intern Med. 2016;165(2):125-33. PMID: 27136449.

13. Examination Focus

Common Exam Questions

  1. First-Line Treatment: "What is the first-line treatment for Chronic Insomnia?"
    • Answer: Cognitive Behavioural Therapy for Insomnia (CBT-I).
  2. Definition of Chronic Insomnia: "How is Chronic Insomnia defined?"
    • Answer: Symptoms ≥3 nights per week for ≥3 months.
  3. Why Avoid Long-Term Hypnotics?: "Why are hypnotics not recommended long-term?"
    • Answer: Risk of Dependence, Tolerance, Next-day sedation, Falls (Especially in elderly), Cognitive impairment.
  4. Early Morning Waking: "Early morning awakening is classically associated with which psychiatric condition?"
    • Answer: Depression.

Viva Points

  • CBT-I Components: Explain Sleep Restriction and Stimulus Control.
  • Melatonin: Licensed for ≥55 years in UK.

Medical Disclaimer: MedVellum content is for educational purposes and clinical reference. Clinical decisions should account for individual patient circumstances. Always consult appropriate specialists.

Last updated: 2025-12-24

At a Glance

EvidenceHigh
Last Updated2025-12-24

Red Flags

  • Suicidal Ideation (Insomnia is a Risk Factor for Suicide)
  • Substance Misuse (Alcohol, Sedatives)
  • Underlying Obstructive Sleep Apnoea (OSA)
  • Symptoms Suggesting Other Sleep Disorder (Narcolepsy, RLS)

Clinical Pearls

  • **CBT-I is First-Line**: Cognitive Behavioural Therapy for Insomnia is more effective than medication in the long term and should be offered first.
  • **"3-3 Rule" for Chronic Insomnia**: ≥3 nights per week for ≥3 months.
  • **Don't Prescribe Long-Term Hypnotics**: Z-drugs and Benzodiazepines are for short-term use only (2-4 weeks). Risk of dependence, next-day sedation, falls.
  • **Always Screen for Comorbidities**: Depression, Anxiety, Sleep Apnoea, Restless Legs, Chronic Pain, Substance use.
  • Male (1.5:1). Increases after menopause.

Guidelines

  • NICE Guidelines
  • BTS Guidelines
  • RCUK Guidelines