Major Trauma
Critical Alerts
- ABCDE approach saves lives: Systematic primary survey identifies life threats
- Hemorrhage is leading preventable death: Control bleeding early
- Permissive hypotension for hemorrhage: Target SBP 80-90 until surgical control (except TBI)
- Massive transfusion protocol: 1:1:1 ratio of RBC:FFP:Platelets
- TXA within 3 hours: Reduces mortality if given early
- Log-roll with C-spine precautions: Until cleared
Key Diagnostics
| Test | Purpose |
|---|---|
| eFAST | Free fluid (abdomen, thorax) at bedside |
| CXR portable | Pneumo/hemothorax, widened mediastinum |
| Pelvis XR | Pelvic fracture |
| CT Pan-scan | Definitive imaging when stable enough |
| Blood gas/lactate | Shock, perfusion status |
| Type and crossmatch | Blood availability |
Emergency Treatments
| Condition | Treatment | Details |
|---|---|---|
| Airway obstruction | RSI with C-spine stabilization | Video laryngoscopy preferred |
| Tension pneumothorax | Needle/Finger thoracostomy | 2nd ICS MCL or 5th ICS MAL |
| Hemorrhage | Direct pressure, tourniquets, MTP | Control bleeding, replace blood |
| TXA | 1g IV bolus | Within 3 hours of injury |
| Pelvic fracture | Pelvic binder | Immediate stabilization |
Overview
Major trauma (polytrauma) refers to injury to multiple body systems with at least one potentially life-threatening injury. It requires a systematic approach using ATLS (Advanced Trauma Life Support) principles, with simultaneous assessment and resuscitation. The goal is to identify and treat immediately life-threatening conditions while preparing for definitive care.
Criteria for Trauma Team Activation
Physiological Criteria:
- GCS ≤13
- SBP <90 mmHg
- RR <10 or >29 (or intubated)
- Penetrating injury to head, neck, torso, extremities proximal to knee/elbow
Anatomical Criteria:
- Flail chest
- Two or more proximal long bone fractures
- Crushed, degloved, or mangled extremity
- Amputation proximal to wrist or ankle
- Pelvic fracture
- Open or depressed skull fracture
- Paralysis
Mechanism Criteria:
- Fall >20 feet (6 meters)
- High-speed MVC (>40 mph with intrusion, ejection, rollover)
- Motorcycle crash >20 mph
- Pedestrian/cyclist struck at significant speed
- Death in same vehicle
- Extrication time >20 minutes
Classification by Injury Severity
| Score (ISS) | Category |
|---|---|
| 1-8 | Minor |
| 9-15 | Moderate |
| 16-24 | Severe |
| ≥25 | Critical |
| >0 | Usually fatal |
Epidemiology
- Leading cause of death: Ages 1-44 years
- Global deaths: 4.4 million annually from injuries
- Trimodal death distribution:
- Immediate (50%): At scene from severe brain/vascular injury
- Early (30%): Within hours from hemorrhage, airway compromise
- Late (20%): Days to weeks from sepsis, MODS
Lethal Triad of Trauma
| Factor | Mechanism | Effect |
|---|---|---|
| Hypothermia | Heat loss, cold fluids, exposure | Coagulopathy, cardiac dysfunction |
| Acidosis | Hypoperfusion, anaerobic metabolism | Coagulopathy, myocardial depression |
| Coagulopathy | Dilution, consumption, hypothermia | Continued bleeding |
Damage Control Resuscitation: Addresses lethal triad
- Permissive hypotension (until surgical control)
- Minimal crystalloid
- Balanced blood product transfusion
- Early hemorrhage control
Hemorrhagic Shock Classes
| Class | Blood Loss | Heart Rate | BP | RR | UOP | Mental Status |
|---|---|---|---|---|---|---|
| I | <15% (<750 mL) | <100 | Normal | 14-20 | >0 | Normal |
| II | 15-30% (750-1500 mL) | 100-120 | Normal | 20-30 | 20-30 | Anxious |
| III | 31-40% (1500-2000 mL) | 120-140 | Decreased | 30-40 | 5-15 | Confused |
| IV | >40% (>000 mL) | >40 | Severely decreased | >5 | Minimal | Lethargic |
Inflammatory Response
- Massive tissue injury → systemic inflammation
- Can progress to ARDS, MODS
- Balance between control of injury and minimizing second hit
Pre-Hospital Information
MIST Handover:
Primary Survey (ABCDE)
A - Airway with C-Spine Protection:
| Finding | Action |
|---|---|
| Stridor, snoring | Jaw thrust, suction, adjuncts |
| Blood/debris in airway | Suction, position |
| Facial trauma, burns | Early intubation |
| Unable to maintain | Definitive airway (RSI) |
B - Breathing:
| Finding | Concern | Action |
|---|---|---|
| Tracheal deviation, distended neck veins, absent breath sounds | Tension pneumothorax | Finger/needle thoracostomy |
| Dullness, decreased breath sounds | Massive hemothorax | Chest tube |
| Paradoxical chest wall movement | Flail chest | O2, analgesia, consider intubation |
| Open chest wound | Open pneumothorax | Three-sided occlusive dressing |
C - Circulation:
| Finding | Concern | Action |
|---|---|---|
| Hypotension + tachycardia | Hemorrhagic shock | IV access, blood products, find source |
| External bleeding | Hemorrhage | Direct pressure, tourniquet |
| Distended neck veins + hypotension | Cardiac tamponade or tension pneumo | Pericardiocentesis/thoracostomy |
| Pelvic instability | Pelvic fracture | Pelvic binder |
| Positive eFAST | Intra-abdominal blood | OR for laparotomy or damage control |
D - Disability:
| Finding | Concern |
|---|---|
| Decreased GCS | TBI |
| Unequal pupils | Herniation |
| Focal deficits | Spinal cord injury |
E - Exposure/Environmental Control:
Secondary Survey
After primary survey stabilization:
Physical Examination:
| Area | Key Findings |
|---|---|
| Head | Lacerations, Battle's sign, raccoon eyes, CSF leak |
| Face | Midface instability, dental trauma |
| Neck | C-spine tenderness, tracheal deviation, JVD |
| Chest | Rib crepitus, paradoxical movement, wounds |
| Abdomen | Distension, tenderness, seat belt sign |
| Pelvis | Instability (test ONCE only), perineal injury |
| Extremities | Deformity, open fractures, pulses |
| Back (log roll) | Step-off, bruising, rectal exam if indicated |
Immediate Life Threats
| Condition | Key Finding | Action |
|---|---|---|
| Airway obstruction | Stridor, inability to speak | Airway management |
| Tension pneumothorax | Hypotension + JVD + absent breath sounds | Decompression |
| Massive hemothorax | >500 mL from chest tube | Thoracotomy |
| Cardiac tamponade | Beck's triad (muffled sounds, JVD, hypotension) | Pericardiocentesis/OR |
| Open pneumothorax | Sucking chest wound | Occlusive dressing |
| Flail chest with respiratory failure | Paradoxical movement | Intubation, PEEP |
| Massive hemorrhage | Shock with identified source | OR, IR, MTP |
| Unstable pelvic fracture | Hypotension + pelvic instability | Binder, embolization |
Indicators of Severe Injury
- GCS ≤8
- SBP <90 despite fluids
- Lactate >4
- Base deficit worse than -6
- Need for massive transfusion
Bedside Diagnostics
eFAST (Extended Focused Assessment with Sonography for Trauma):
| View | Purpose |
|---|---|
| RUQ (Morison's pouch) | Hepatorenal blood |
| LUQ (Splenorenal) | Perisplenic blood |
| Pelvis (suprapubic) | Pelvic blood |
| Cardiac (subxiphoid/parasternal) | Pericardial effusion |
| Thoracic (bilateral) | Hemothorax, pneumothorax |
Interpretation:
- Positive eFAST in unstable patient → OR
- Negative eFAST doesn't exclude injury (hollow viscus, retroperitoneal)
Portable Imaging:
- CXR: Pneumothorax, hemothorax, widened mediastinum
- Pelvis XR: Pelvic fracture
Laboratory Studies
| Test | Purpose |
|---|---|
| Type and crossmatch | Blood availability |
| CBC | Baseline Hgb (may be normal initially) |
| Coagulation (PT, PTT, fibrinogen) | Coagulopathy |
| BMP | Electrolytes, renal function |
| ABG/VBG with lactate | Perfusion, acidosis |
| Troponin | Cardiac contusion |
| Lipase | Pancreatic injury |
| Pregnancy test | All females of childbearing age |
CT Imaging ("Pan-Scan")
When Patient Stabilized:
| Study | Purpose |
|---|---|
| CT Head | TBI, skull fracture |
| CT C-Spine | Cervical injury |
| CT Chest | Thoracic injury |
| CT Abdomen/Pelvis with contrast | Solid organ, bowel, vascular injury |
| CT Angiography | Vascular injury if suspected |
CT Should NOT Delay:
- OR for unstable hemodynamics
- Critical interventions
Damage Control Resuscitation
Principles:
- Permissive hypotension (SBP 80-90) until surgical control (except TBI)
- Limit crystalloid (avoid dilutional coagulopathy)
- Balanced transfusion (1:1:1 RBC:FFP:Platelets)
- Early TXA (within 3 hours)
- Prevent hypothermia
Massive Transfusion Protocol (MTP):
| Trigger Criteria |
|---|
| Requiring > units RBC in 1 hour |
| ABC Score ≥2 (HR >20, SBP ≤90, penetrating mechanism, positive eFAST) |
| Obvious massive hemorrhage |
Transfusion Ratio:
- 1:1:1 (RBC : FFP : Platelets)
- Or 6:4:1 unit ratio
Tranexamic Acid (TXA):
- 1g IV over 10 minutes within 3 hours of injury
- Then 1g over 8 hours
- Proven mortality benefit in bleeding trauma
Airway Management
Indications for Intubation:
- Airway obstruction
- GCS ≤8
- Respiratory failure
- Anticipated clinical course
- Need for safe transfer/imaging
RSI Technique:
- C-spine inline stabilization (remove front of collar)
- Video laryngoscopy preferred
- Have surgical airway ready
Chest Trauma Interventions
| Condition | Intervention |
|---|---|
| Tension pneumothorax | Finger thoracostomy → chest tube |
| Open pneumothorax | Three-sided dressing → chest tube |
| Massive hemothorax | Chest tube (large bore 32-36F) → consider thoracotomy |
| Cardiac tamponade | Pericardiocentesis or ED thoracotomy |
| Flail chest | Intubation + PEEP if failing |
ED (Resuscitative) Thoracotomy:
| Indication | Purpose |
|---|---|
| Penetrating trauma with arrest or near-arrest | Cardiac massage, aortic cross-clamp, tamponade release |
| Blunt trauma | Much lower survival; selective use |
Hemorrhage Control
External Hemorrhage:
- Direct pressure
- Tourniquets (life limb extremity bleeding)
- Wound packing with hemostatic agents
Internal Hemorrhage:
| Source | Intervention |
|---|---|
| Thorax | Chest tube; thoracotomy if >1500 mL initial or >00 mL/hr |
| Abdomen | Damage control laparotomy; OR |
| Pelvis | Pelvic binder → IR angioembolization or preperitoneal packing |
| Retroperitoneum | Often non-operative or IR |
Pelvic Fracture Management
Immediate Actions:
- Pelvic binder (reduce volume, tamponade bleeding)
- Avoid log-roll (can displace clot)
- MTP if hemorrhagic shock
Definitive Options:
- Angioembolization (arterial bleeding)
- Preperitoneal packing (venous bleeding)
- External fixation
C-Spine Management
Immobilization:
- Maintain until cleared clinically or radiographically
- Collar + spine board (limit time on board)
Clearance:
- NEXUS criteria or Canadian C-Spine Rule
- If not clinically clearable → CT C-spine
Immediate OR Indications
- Positive eFAST with hemodynamic instability
- Massive hemothorax
- Class III-IV hemorrhagic shock with identified surgical source
- Penetrating torso trauma with instability
- ED thoracotomy survivors
ICU Admission
- All major trauma
- Need for mechanical ventilation
- Ongoing resuscitation
- Monitoring for delayed complications
Transfer Considerations
- Transfer to trauma center if Level I/II care not available
- Stabilize before transfer
- Do not delay transfer for non-essential imaging
Tertiary Survey
Within 24 Hours:
- Repeat head-to-toe exam
- Review all imaging
- Identify missed injuries (up to 10% initially missed)
Condition Explanation
- "Your family member has been seriously injured in multiple parts of the body."
- "We are focusing on stopping any bleeding and making sure they can breathe."
- "They may need surgery and will be in the intensive care unit."
Expected Course
- Multiple surgeries may be needed
- ICU stay likely prolonged
- Rehabilitation will be important
- Psychological support available
Involvement
- Designated family contact for updates
- Social work and chaplain services
- ICU family meetings
Pediatric Trauma
- Higher surface area to volume → rapid heat loss
- Blood volume ~80 mL/kg
- Immature skeleton → internal injury without fractures
- Head is disproportionately large
- Cardiac output depends on heart rate
Geriatric Trauma
- Lower physiologic reserve
- Pre-existing anticoagulation
- May not mount tachycardia (beta-blockers)
- Consider TBI with even minor mechanism
- Frailty impacts outcomes
Pregnant Trauma Patients
- Prioritize mother: Best care for fetus is care for mother
- Left lateral tilt or manual uterine displacement
- Rhogam if Rh-negative
- Obstetrics consultation
- Early fetal monitoring
- Emergency cesarean if maternal arrest and >24 weeks
Anticoagulated Patients
- Reverse anticoagulation early
- 4-factor PCC for warfarin
- Idarucizumab for dabigatran
- TXA still indicated
Burns + Trauma
- Airway priority (inhalation injury)
- Fluid resuscitation for burns
- Escharotomy for circumferential burns
Performance Indicators
| Metric | Target |
|---|---|
| Primary survey completion | <10 minutes |
| Time to OR for unstable patient | <60 minutes |
| TXA administration within 3 hours | >0% |
| MTP activated appropriately | 100% when indicated |
| Tertiary survey within 24h | 100% |
| Hypothermia prevention documented | 100% |
Documentation Requirements
- Mechanism and pre-hospital information
- Primary survey findings
- Secondary survey findings
- Imaging and lab results
- Procedures performed
- Blood products given
- Time stamps for key interventions
Diagnostic Pearls
- Primary survey is treatment: Intervene as you find problems
- eFAST positive + unstable = OR: Don't delay for CT
- Lactate is a resuscitation marker: Rising lactate = ongoing hypoperfusion
- Don't trust initial hemoglobin: May be normal despite massive blood loss
- Log-roll to examine the back: Don't miss posterior injuries
- CT pan-scan when stable: Identifies occult injuries
Treatment Pearls
- Lethal triad kills: Warm, stop acidosis, give blood
- Permissive hypotension: SBP 80-90 until bleeding controlled (NOT in TBI)
- TXA works: Give within 3 hours
- 1:1:1 transfusion: Don't resuscitate with crystalloid
- Pelvic binder early: For pelvic fractures
- ED thoracotomy has role: Penetrating arrest with brief down time
Disposition Pearls
- All major trauma to trauma center: Transfer if needed
- Tertiary survey finds missed injuries: Do within 24 hours
- ICU admission standard: For monitoring and ongoing resuscitation
- Family communication early: Assign liaison
- American College of Surgeons Committee on Trauma. ATLS: Advanced Trauma Life Support Student Course Manual, 10th ed. 2018.
- CRASH-2 Trial Collaborators. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients. Lancet. 2010;376(9734):23-32.
- Holcomb JB, et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma. JAMA. 2015;313(5):471-482.
- Spahn DR, et al. The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition. Crit Care. 2019;23(1):98.
- Cannon JW, et al. Damage Control Resuscitation. J Trauma Acute Care Surg. 2020;89(2S):S168-S174.
- Fox EE, et al. Earlier endpoints are required for hemorrhagic shock trials among severely injured patients. Shock. 2017;47(5):567-573.
- Brenner M, et al. Resuscitative endovascular balloon occlusion of the aorta and resuscitative thoracotomy. J Trauma Acute Care Surg. 2018;85(6):1013-1019.
- UpToDate. Initial management of trauma in adults. 2024.