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Orthopaedics
Emergency
EMERGENCY

Open Fracture

High EvidenceUpdated: 2025-12-25

On This Page

Red Flags

  • Signs of compartment syndrome
  • Signs of vascular injury (pulseless, pale, cold)
  • Signs of nerve injury (numbness, weakness)
  • Severe contamination
  • Delayed presentation (>6 hours)
  • Signs of infection
Overview

Open Fracture

1. Clinical Overview

Summary

An open fracture (also called a compound fracture) is a broken bone where the broken ends have pierced through the skin, creating a direct connection between the fracture site and the outside environment. Think of a broken bone like a snapped stick—when the sharp ends break through the skin, bacteria from the outside can get into the bone, causing a high risk of infection. This is a serious orthopedic emergency that requires urgent treatment to prevent infection, preserve function, and ensure proper healing. Open fractures are classified by severity (Gustilo-Anderson classification), with higher grades having more soft tissue damage and higher infection risk. The key to management is immediate assessment (ABCs, neurovascular status), wound care (cover, don't probe), antibiotics (broad-spectrum), tetanus prophylaxis, urgent surgical debridement and fixation, and close monitoring for complications (infection, compartment syndrome, non-union). Most open fractures heal well with proper treatment, but infection remains a significant risk, especially in higher-grade injuries.

Key Facts

  • Definition: Fracture with breach of skin/soft tissue, exposing bone
  • Incidence: Common (5-10% of all fractures)
  • Mortality: Low (<1%) unless complications (infection, vascular injury)
  • Peak age: All ages, but more common in young adults (trauma)
  • Critical feature: Broken bone visible through skin or wound communicates with fracture
  • Key investigation: Clinical diagnosis, X-ray, assess for complications
  • First-line treatment: Urgent surgical debridement, antibiotics, fixation

Clinical Pearls

"Time to surgery matters" — Open fractures should go to surgery within 6 hours ideally (golden period). Delayed treatment increases infection risk significantly.

"Don't probe the wound" — Never probe or extensively examine the wound in the emergency department. Cover it, give antibiotics, and get to surgery. Probing can push bacteria deeper.

"Gustilo classification predicts infection risk" — Grade I (low energy, small wound) has ~2% infection risk. Grade III (high energy, extensive soft tissue damage) has 10-50% infection risk.

"Always check neurovascular status" — Open fractures can have associated vascular or nerve injuries. Check pulses, sensation, movement immediately and repeatedly.

Why This Matters Clinically

Open fractures are serious injuries with high infection risk if not treated promptly and properly. Early recognition, appropriate wound care, antibiotics, and urgent surgical debridement are essential to prevent infection and preserve function. This is a condition that emergency and orthopedic clinicians manage, and prompt treatment can prevent serious complications.


2. Epidemiology

Incidence & Prevalence

  • Overall: Common (5-10% of all fractures)
  • Trend: Stable (common in trauma)
  • Peak age: All ages, but more common in young adults (trauma)

Demographics

FactorDetails
AgeAll ages, but more common in young adults (15-40 years)
SexMale predominance (trauma patterns)
EthnicityNo significant variation
GeographyHigher in urban areas (trauma)
SettingEmergency departments, trauma centers

Risk Factors

Non-Modifiable:

  • Age (young adults = more trauma)
  • Male sex (trauma patterns)

Modifiable:

Risk FactorRelative RiskMechanism
High-energy trauma5-10xMore severe injury
Road traffic accidents3-5xHigh-energy mechanism
Falls from height3-5xHigh-energy mechanism
Gunshot wounds5-10xHigh-energy, contamination
Farm/industrial injuries2-3xContamination risk

Common Mechanisms

MechanismFrequencyTypical Patient
Road traffic accidents40-50%Young adults, high energy
Falls20-30%Various ages
Sports injuries10-15%Young adults
Gunshot wounds5-10%Various
Other10-15%Various

3. Pathophysiology

The Injury Mechanism

Step 1: High-Energy Impact

  • Force: High-energy force applied to bone
  • Bone breaks: Fracture occurs
  • Soft tissue damage: Surrounding tissues damaged
  • Result: Bone breaks, soft tissues torn

Step 2: Skin Breach

  • Bone ends: Sharp bone ends pierce skin
  • Wound: Open wound created
  • Contamination: Bacteria enter from outside
  • Result: Fracture exposed to environment

Step 3: Infection Risk

  • Bacteria: Enter through wound
  • Bone exposure: Bone has poor blood supply
  • Devitalized tissue: Dead tissue provides medium for bacteria
  • Result: High infection risk

Step 4: Healing Challenges

  • Infection: Can prevent healing
  • Soft tissue loss: May need reconstruction
  • Bone healing: May be delayed or fail (non-union)
  • Result: Complex healing process

Classification (Gustilo-Anderson)

GradeDefinitionWound SizeSoft TissueInfection Risk
ILow energy, clean wound<1cmMinimal~2%
IIModerate energy, moderate wound>1cmModerate~5%
IIIAHigh energy, adequate soft tissueVariableAdequate coverage~10%
IIIBHigh energy, inadequate soft tissueVariableInadequate coverage, needs flap~20%
IIICHigh energy, vascular injuryVariableVascular injury~50%

Anatomical Considerations

Common Sites:

  • Tibia: Most common (thin skin, vulnerable)
  • Femur: Less common but serious
  • Radius/ulna: Common
  • Other: Various

Why These Sites:

  • Thin skin: More likely to breach
  • Superficial bone: Less soft tissue protection
  • High-energy mechanisms: More force

4. Clinical Presentation

Symptoms: The Patient's Story

Typical Presentation:

History:

Signs: What You See

Vital Signs (May Be Abnormal):

SignFindingSignificance
TemperatureUsually normal (may be elevated if infection)Fever suggests infection
Heart rateMay be high (pain, blood loss)Tachycardia
Blood pressureMay be low (blood loss)Hypotension, shock

General Appearance:

Local Examination:

FindingWhat It MeansFrequency
Open woundSkin breach, bone visible or wound communicatesAlways
DeformityObvious fracture deformity80-90%
SwellingSoft tissue swellingCommon
BruisingSoft tissue damageCommon
BleedingActive bleedingCommon

Neurovascular Examination (Critical):

FindingWhat It MeansSignificance
PulsesCheck distal pulsesVascular injury if absent
SensationCheck sensationNerve injury if abnormal
MovementCheck movementNerve/muscle injury if abnormal
ColorCheck colorIschemia if pale
TemperatureCheck temperatureIschemia if cold

Signs of Complications:

Red Flags

[!CAUTION] Red Flags — Immediate Escalation Required:

  • Signs of compartment syndrome — Medical emergency, needs urgent fasciotomy
  • Signs of vascular injury (pulseless, pale, cold) — Medical emergency, needs urgent vascular repair
  • Signs of nerve injury (numbness, weakness) — Needs urgent assessment
  • Severe contamination — Higher infection risk, needs thorough debridement
  • Delayed presentation (>6 hours) — Higher infection risk, needs urgent treatment
  • Signs of infection — Needs urgent treatment, may need revision surgery

Pain
Severe pain at fracture site
Deformity
Obvious deformity
Wound
Open wound with bone visible or wound communicates with fracture
Bleeding
May have bleeding from wound
Unable to bear weight
If lower limb
Unable to use limb
If upper limb
5. Clinical Examination

Structured Approach: ABCDE

A - Airway

  • Assessment: Usually patent (unless other injuries)
  • Action: Secure if compromised

B - Breathing

  • Look: Usually normal (unless chest injury)
  • Listen: Usually normal
  • Measure: SpO2 (usually normal)
  • Action: Support if needed

C - Circulation

  • Look: May have blood loss (check for shock)
  • Feel: Pulse (may be high), BP (may be low)
  • Listen: Heart sounds (usually normal)
  • Measure: BP (may be low), HR (may be high)
  • Action: IV fluids if blood loss, control bleeding

D - Disability

  • Assessment: Neurological status (GCS if head injury)
  • Action: Assess if other injuries

E - Exposure

  • Look: Full examination, check for other injuries
  • Feel: Neurovascular status
  • Action: Complete examination

Specific Examination Findings

Wound Examination (Limited):

  • Don't probe: Never probe wound in ED
  • Cover: Cover with sterile dressing
  • Assess: Size, contamination, soft tissue damage (visual only)
  • Document: Gustilo grade if possible

Neurovascular Examination (Critical):

  • Pulses: Check distal pulses (doppler if needed)
  • Sensation: Check sensation in distribution
  • Movement: Check active movement
  • Color: Check color
  • Temperature: Check temperature
  • Capillary refill: Check capillary refill

Signs of Compartment Syndrome:

  • Pain: Severe, out of proportion
  • Tense swelling: Hard, tense compartment
  • Pain on passive stretch: Very painful
  • Paresthesia: Numbness
  • Pulses: Usually present (late sign if absent)

Special Tests

TestTechniquePositive FindingClinical Use
Neurovascular examinationCheck pulses, sensation, movementAbnormalitiesIdentifies complications
Compartment pressureMeasure compartment pressure>30mmHgConfirms compartment syndrome
DopplerCheck pulses with dopplerAbsent pulsesIdentifies vascular injury

6. Investigations

First-Line (Bedside) - Do Immediately

1. Clinical Diagnosis (Usually Obvious)

  • History: Trauma, mechanism
  • Examination: Open wound, deformity
  • Action: Usually obvious, proceed to treatment

2. X-Ray (Essential)

  • Purpose: Confirms fracture, assesses pattern
  • Finding: Fracture visible, may show displacement
  • Action: Essential before surgery

Laboratory Tests

TestExpected FindingPurpose
Full Blood CountMay show anemia (blood loss)Assesses blood loss
Group and Save/CrossmatchBlood typeMay need transfusion
CoagulationUsually normalBaseline
Urea & ElectrolytesUsually normalBaseline

Imaging

X-Ray (Essential):

IndicationFindingClinical Note
All open fracturesFracture pattern, displacementEssential before surgery

CT (If Needed):

IndicationFindingClinical Note
Complex fracturesDetailed fracture patternIf needed for planning
Joint involvementJoint involvementIf suspected

Angiography (If Vascular Injury):

IndicationFindingClinical Note
Vascular injury suspectedVascular injuryIf pulses absent or abnormal

Diagnostic Criteria

Clinical Diagnosis:

  • Open wound + fracture (clinical or X-ray) = Open fracture

Gustilo Classification:

  • Grade I: Clean wound <1cm, low energy
  • Grade II: Wound >1cm, moderate energy
  • Grade IIIA: High energy, adequate soft tissue
  • Grade IIIB: High energy, inadequate soft tissue
  • Grade IIIC: High energy, vascular injury

7. Management

Management Algorithm

        OPEN FRACTURE PRESENTATION
    (Open wound + fracture)
                    ↓
┌─────────────────────────────────────────────────┐
│         IMMEDIATE ASSESSMENT (ABCDE)            │
│  • Airway, Breathing, Circulation               │
│  • Control bleeding (pressure, not tourniquet)  │
│  • Assess for other injuries                     │
└─────────────────────────────────────────────────┘
                    ↓
┌─────────────────────────────────────────────────┐
│         WOUND CARE                               │
│  • Cover with sterile dressing                   │
│  • Don't probe wound                             │
│  • Don't reduce fracture (in ED)                 │
│  • Splint fracture                               │
└─────────────────────────────────────────────────┘
                    ↓
┌─────────────────────────────────────────────────┐
│         NEUROVASCULAR ASSESSMENT                 │
│  • Check pulses (doppler if needed)              │
│  • Check sensation                               │
│  • Check movement                                │
│  • Document findings                             │
└─────────────────────────────────────────────────┘
                    ↓
┌─────────────────────────────────────────────────┐
│         ANTIBIOTICS                              │
│  • Broad-spectrum (co-amoxiclav or cefuroxime)   │
│  • Give immediately                              │
│  • Continue until wound closure                  │
└─────────────────────────────────────────────────┘
                    ↓
┌─────────────────────────────────────────────────┐
│         TETANUS PROPHYLAXIS                      │
│  • Check tetanus status                          │
│  • Give if not up to date                        │
└─────────────────────────────────────────────────┘
                    ↓
┌─────────────────────────────────────────────────┐
│         URGENT SURGERY                           │
│  • Within 6 hours (golden period)                │
│  • Debridement (remove dead tissue)               │
│  • Irrigation (wash out)                         │
│  • Fixation (internal or external)                │
│  • Wound management (closure or coverage)        │
└─────────────────────────────────────────────────┘
                    ↓
┌─────────────────────────────────────────────────┐
│         POST-OPERATIVE                           │
│  • Continue antibiotics                          │
│  • Monitor for infection                         │
│  • Monitor for compartment syndrome              │
│  • Rehabilitation                                │
└─────────────────────────────────────────────────┘

Acute/Emergency Management - The First Hour

Immediate Actions (Do Simultaneously):

  1. ABCs (Airway, Breathing, Circulation)

    • Assess: Full ABCDE assessment
    • Control bleeding: Pressure (not tourniquet unless life-threatening)
    • Action: Resuscitate if needed
  2. Wound Care

    • Cover: Sterile dressing (don't probe)
    • Splint: Splint fracture
    • Don't reduce: Don't reduce in ED (do in surgery)
    • Action: Protect wound, immobilize
  3. Neurovascular Assessment

    • Pulses: Check distal pulses (doppler if needed)
    • Sensation: Check sensation
    • Movement: Check movement
    • Document: Document findings
    • Action: Identify complications early
  4. Antibiotics

    • Broad-spectrum: Co-amoxiclav 1.2g IV or cefuroxime 1.5g IV
    • Give immediately: Don't delay
    • Continue: Until wound closure
  5. Tetanus Prophylaxis

    • Check status: Tetanus vaccination status
    • Give if needed: Tetanus toxoid if not up to date
    • Action: Prevent tetanus
  6. Urgent Surgery

    • Within 6 hours: Golden period
    • Debridement: Remove dead tissue
    • Irrigation: Wash out thoroughly
    • Fixation: Internal or external fixation
    • Wound: Closure or coverage

Medical Management

Antibiotics (Essential):

DrugDoseRouteDurationNotes
Co-amoxiclav1.2gIVTDSUntil wound closure
Cefuroxime1.5gIVTDSAlternative
Gentamicin5mg/kgIVODAdd if severe (Grade III)

Mechanism: Prevents infection

Tetanus Prophylaxis:

StatusAction
Up to dateNone needed
Not up to dateTetanus toxoid
UnknownTetanus toxoid

Analgesia:

DrugDoseRouteNotes
Morphine5-10mgIVAs needed
Paracetamol1gIV/PORegular
NSAIDsAs appropriatePOIf no contraindications

Surgical Management

Debridement (Essential):

  • Remove: All dead tissue, foreign material
  • Irrigate: Thorough irrigation
  • Assess: Viability of tissues

Fixation:

  • Internal: Plates, screws (if soft tissue allows)
  • External: External fixator (if severe soft tissue damage)
  • Timing: Usually immediate (primary fixation) or delayed (if severe)

Wound Management:

  • Primary closure: If clean, low grade (Grade I)
  • Delayed closure: If contaminated, high grade (Grade II-III)
  • Flap coverage: If soft tissue loss (Grade IIIB)

Disposition

Admit to Hospital:

  • All open fractures: Need surgery, monitoring
  • Regular follow-up: Monitor for infection, healing

Discharge Criteria:

  • Not applicable: All need admission and surgery

Follow-Up:

  • Wound: Monitor for infection
  • Healing: Monitor bone healing
  • Rehabilitation: Start early
  • Long-term: May need further surgery

8. Complications

Immediate (Days-Weeks)

ComplicationIncidencePresentationManagement
Infection2-50% (depends on grade)Redness, discharge, feverDebridement, antibiotics, may need removal of metalwork
Compartment syndrome5-10%Severe pain, tense swellingUrgent fasciotomy
Vascular injury5-10%Absent pulses, ischemiaUrgent vascular repair
Nerve injury10-20%Numbness, weaknessMay recover, may need repair

Infection:

  • Mechanism: Bacteria enter through wound
  • Management: Debridement, antibiotics, may need removal of metalwork
  • Prevention: Early surgery, antibiotics, proper debridement

Compartment Syndrome:

  • Mechanism: Swelling increases pressure
  • Management: Urgent fasciotomy
  • Prevention: Monitor, early recognition

Early (Weeks-Months)

1. Delayed Union (10-20%)

  • Mechanism: Bone doesn't heal in expected time
  • Management: May need further surgery
  • Prevention: Proper fixation, infection control

2. Non-Union (5-10%)

  • Mechanism: Bone doesn't heal
  • Management: Bone graft, revision fixation
  • Prevention: Proper fixation, infection control

3. Malunion (5-10%)

  • Mechanism: Bone heals in wrong position
  • Management: May need correction
  • Prevention: Proper reduction, fixation

Late (Months-Years)

1. Chronic Infection (2-5%)

  • Mechanism: Persistent infection
  • Management: Long-term antibiotics, may need removal of metalwork
  • Prevention: Early treatment, proper debridement

2. Osteomyelitis (2-5%)

  • Mechanism: Bone infection
  • Management: Long-term antibiotics, debridement
  • Prevention: Early treatment, infection control

3. Functional Impairment (10-20%)

  • Mechanism: Residual disability
  • Management: Rehabilitation, may need further surgery
  • Prevention: Early rehabilitation, proper treatment

9. Prognosis & Outcomes

Natural History (Without Treatment)

Untreated Open Fracture:

  • High infection risk: Almost certain infection
  • Poor healing: Non-union likely
  • Functional loss: Significant disability

Outcomes with Treatment

VariableOutcomeNotes
Infection2-50% (depends on grade)Lower with proper treatment
Union80-90%Most heal with proper treatment
Functional recovery70-80%Most regain good function
Mortality<1%Very low unless complications

Factors Affecting Outcomes:

Good Prognosis:

  • Early treatment: Better outcomes (<6 hours)
  • Low grade: Grade I-II have better outcomes
  • Proper debridement: Reduces infection risk
  • No complications: Better outcomes

Poor Prognosis:

  • Delayed treatment: Higher infection risk
  • High grade: Grade III have worse outcomes
  • Complications: Infection, compartment syndrome worsen outcomes
  • Severe contamination: Higher infection risk

Prognostic Factors

FactorImpact on PrognosisEvidence Level
Time to surgery<6 hours = betterHigh
Gustilo gradeLower grade = betterHigh
Proper debridementBetter outcomesHigh
ComplicationsComplications = worseHigh

10. Evidence & Guidelines

Key Guidelines

1. BOA Guidelines (2017) — Standards for the management of open fractures. British Orthopaedic Association

Key Recommendations:

  • Urgent surgery within 6 hours
  • Broad-spectrum antibiotics
  • Proper debridement
  • Evidence Level: 1A

2. EAST Guidelines (2012) — Management of open fractures. Eastern Association for the Surgery of Trauma

Key Recommendations:

  • Urgent debridement
  • Antibiotics
  • Evidence Level: 1A

Landmark Trials

Multiple studies on timing of surgery, antibiotic use, infection prevention.

Evidence Strength

InterventionLevelKey EvidenceClinical Recommendation
Urgent surgery1AMultiple studiesWithin 6 hours
Antibiotics1AMultiple RCTsEssential
Debridement1AUniversalEssential

11. Patient/Layperson Explanation

What is an Open Fracture?

An open fracture (also called a compound fracture) is a broken bone where the broken ends have pierced through the skin, creating a direct connection between the fracture and the outside. Think of a broken bone like a snapped stick—when the sharp ends break through the skin, bacteria from the outside can get into the bone, causing a high risk of infection.

In simple terms: Your bone is broken and the broken ends have come through the skin. This is serious because it can get infected, but with proper treatment, most people recover well.

Why does it matter?

Open fractures are serious injuries with a high risk of infection if not treated promptly and properly. Early treatment (surgery to clean the wound and fix the bone) is essential to prevent infection and ensure proper healing. The good news? With proper treatment, most people recover well and regain good function.

Think of it like this: It's like breaking a bone and the sharp ends cutting through your skin—it needs urgent treatment to prevent infection and help it heal properly.

How is it treated?

1. Immediate Care:

  • Wound: The wound will be covered with a sterile dressing (don't touch it)
  • Splint: The fracture will be splinted to keep it still
  • Antibiotics: You'll get antibiotics immediately to prevent infection
  • Tetanus: You'll get a tetanus shot if needed

2. Urgent Surgery:

  • When: Usually within 6 hours (the sooner the better)
  • What: The surgeon will clean the wound thoroughly (remove dead tissue, wash it out), fix the bone (with metal plates/screws or an external frame), and manage the wound (may leave it open initially if contaminated)
  • Why: To prevent infection and help the bone heal properly

3. After Surgery:

  • Antibiotics: You'll continue antibiotics until the wound is closed
  • Monitoring: You'll be monitored for infection and other complications
  • Rehabilitation: You'll start rehabilitation to regain function

The goal: Prevent infection, help the bone heal properly, and regain function.

What to expect

Recovery:

  • Surgery: Usually within 6 hours of injury
  • Hospital stay: Usually a few days to weeks (depends on severity)
  • Wound: May be left open initially, closed later if needed
  • Bone healing: Usually takes weeks to months

After Treatment:

  • Wound: Will be monitored for infection
  • Bone: Will be monitored for healing
  • Rehabilitation: Will start early to regain function
  • Follow-up: Regular follow-up to monitor progress

Recovery Time:

  • Wound healing: Usually weeks
  • Bone healing: Usually months (6-12 weeks or longer)
  • Full recovery: Usually months to a year

When to seek help

This is already an emergency — If you have an open fracture, you should already be in the hospital getting treatment.

After treatment, see your doctor if:

  • Your wound becomes red, swollen, or has discharge
  • You have a fever
  • You have increasing pain
  • You have concerns about your recovery

Call 999 (or your emergency number) immediately if:

  • You have severe pain that's getting worse
  • Your limb becomes pale, cold, or numb
  • You feel very unwell
  • You have signs of infection (redness, discharge, fever)

Remember: Open fractures are serious injuries that need urgent treatment. If you have an open fracture, you should be in the hospital getting treatment. After treatment, follow your doctor's advice and watch for signs of infection or other complications.


12. References

Primary Guidelines

  1. British Orthopaedic Association. Standards for the management of open fractures. BOA. 2017.

  2. Eastern Association for the Surgery of Trauma. Management of open fractures. EAST Practice Management Guidelines. 2012.

Key Trials

  1. Multiple studies on timing of surgery, antibiotic use, and infection prevention.

Further Resources

  • BOA Guidelines: British Orthopaedic Association

Last Reviewed: 2025-12-25 | MedVellum Editorial Team


Medical Disclaimer: MedVellum content is for educational purposes and clinical reference. Clinical decisions should account for individual patient circumstances. Always consult appropriate specialists. This information is not a substitute for professional medical advice, diagnosis, or treatment.

Last updated: 2025-12-25

At a Glance

EvidenceHigh
Last Updated2025-12-25
Emergency Protocol

Red Flags

  • Signs of compartment syndrome
  • Signs of vascular injury (pulseless, pale, cold)
  • Signs of nerve injury (numbness, weakness)
  • Severe contamination
  • Delayed presentation (&gt;6 hours)
  • Signs of infection

Clinical Pearls

  • **"Time to surgery matters"** — Open fractures should go to surgery within 6 hours ideally (golden period). Delayed treatment increases infection risk significantly.
  • **"Don't probe the wound"** — Never probe or extensively examine the wound in the emergency department. Cover it, give antibiotics, and get to surgery. Probing can push bacteria deeper.
  • **"Gustilo classification predicts infection risk"** — Grade I (low energy, small wound) has ~2% infection risk. Grade III (high energy, extensive soft tissue damage) has 10-50% infection risk.
  • **"Always check neurovascular status"** — Open fractures can have associated vascular or nerve injuries. Check pulses, sensation, movement immediately and repeatedly.
  • **Red Flags — Immediate Escalation Required:**

Guidelines

  • NICE Guidelines
  • BTS Guidelines
  • RCUK Guidelines