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Pediatric Resuscitation

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Overview

Pediatric Resuscitation

Quick Reference

Critical Alerts

  • Pediatric arrest is usually respiratory: Hypoxia leads to bradycardia then arrest
  • Ventilation is paramount: Oxygenation and ventilation often reverse bradycardia
  • CPR ratio 15:2 for 2 rescuers, 30:2 for single rescuer: Different from adults
  • Shockable rhythms (VF/pVT) are less common: But outcomes better when present
  • Epinephrine every 3-5 min: 0.01 mg/kg IV/IO (0.1 mL/kg of 1:10,000)
  • Defibrillation 2 J/kg → 4 J/kg → ≥4 J/kg: Max 10 J/kg or adult dose

Pediatric Age Definitions

Age GroupDefinition
Neonate<28lt;28 days
Infant<1 yearlt;1 year
Child1 year to puberty
AdolescentPuberty and beyond (use adult protocols)

Key Drug Doses

DrugDoseRoute
Epinephrine0.01 mg/kg (0.1 mL/kg of 1:10,000)IV/IO q3-5 min
Amiodarone5 mg/kgIV/IO (max 300 mg first dose)
Lidocaine1 mg/kgIV/IO
Defibrillation2 J/kg → 4 J/kg → ≥4 J/kg (max 10 J/kg)Biphasic
Adenosine0.1 mg/kg → 0.2 mg/kgRapid IV push

BLS Summary

ComponentInfant (<1 yrlt;1 yr)Child (1 yr to puberty)
Compression depth1.5 inches (4 cm)2 inches (5 cm)
Compression rate100-120/min100-120/min
Compression technique2 fingers or 2 thumbsHeel of 1 or 2 hands
Rescue breaths1 breath every 2-3 sec1 breath every 2-3 sec
CPR ratio (2 rescuers)15:215:2
CPR ratio (single rescuer)30:230:2

Definition

Overview

Pediatric cardiac arrest differs from adult arrest in etiology (usually respiratory), rhythm (usually asystole/PEA), and management approach. Pediatric Advanced Life Support (PALS) provides the standardized approach. Prevention of arrest through early recognition and treatment of respiratory failure and shock is critical.

Classification

By Initial Rhythm:

RhythmIncidenceTreatment
Asystole/PEA~90%CPR + Epinephrine; identify reversible cause
VF/pVT~10%CPR + Defibrillation + Epinephrine/Amiodarone

By Etiology:

TypeCommon Causes
RespiratoryAirway obstruction, drowning, asthma, pneumonia, SIDS
CirculatorySeptic shock, hypovolemia, trauma
CardiacCongenital heart disease, arrhythmia, myocarditis

Epidemiology

  • Out-of-hospital pediatric cardiac arrest survival: ~10-15%
  • In-hospital pediatric cardiac arrest survival: ~40-50%
  • Most common initial rhythm: Asystole/PEA (>80-90%)
  • VF/pVT more common in: Congenital heart disease, witnessed arrest, adolescents

Etiology

Common Causes (H's and T's):

H'sT's
Hypoxia (most common)Tension pneumothorax
HypovolemiaTamponade (cardiac)
Hydrogen ion (acidosis)Toxins
Hypo/HyperkalemiaThrombosis (PE, coronary)
HypothermiaTrauma
Hypoglycemia

Pathophysiology

Respiratory Arrest → Cardiac Arrest

Typical Sequence:

  1. Respiratory distress (compensated)
  2. Respiratory failure (decompensated)
  3. Hypoxia → Bradycardia
  4. Cardiovascular collapse → Arrest (asystole/PEA)

Why Ventilation Is Key

  • Pediatric arrest is usually preceded by hypoxia
  • Early oxygenation and ventilation may prevent progression
  • Bradycardia often responds to effective ventilation

Cardiac Arrest Without Warning

  • Less common in children (vs adults)
  • Occurs in: Congenital heart disease, sudden arrhythmia, hypertrophic cardiomyopathy, long QT syndrome

Clinical Presentation

Recognition of Impending Arrest

Pre-Arrest Warning Signs:

SystemFindings
RespiratoryApnea, gasping, severe work of breathing, cyanosis
CardiovascularBradycardia <60lt;60, hypotension, poor perfusion
NeurologicalUnresponsive, limp

Signs of Cardiac Arrest

Pulse Check (≤10 seconds):

AgeLocation
InfantBrachial or femoral artery
ChildCarotid or femoral artery

Unresponsive
Common presentation.
Absent or abnormal breathing (gasping, agonal)
Common presentation.
No pulse or unsure of pulse
Common presentation.
Red Flags

High-Risk for Arrest

FindingAction
HR <60lt;60 with poor perfusionStart CPR
Apnea or agonal breathingStart rescue breathing/CPR
Severe respiratory distress not improvingPrepare for arrest
Altered LOC + shockAggressive resuscitation
Unwitnessed sudden collapse in adolescentHigh likelihood VF—get AED/defibrillator

Treatment

Pediatric BLS Algorithm

Step 1: Check Responsiveness and Breathing

  • Tap and shout
  • Look for breathing (5-10 seconds)

Step 2: Call for Help

  • Activate emergency response
  • Get AED/defibrillator

Step 3: Check Pulse (≤10 seconds)

  • If no pulse or unsure → Start CPR

Step 4: CPR

ParameterInfantChild
Compression depth1.5 inches (4 cm)2 inches (5 cm)
Compression rate100-120/min100-120/min
Allow full chest recoilYesYes
Minimize interruptionsYesYes
Compression-to-breath ratio15:2 (2 rescuers) or 30:2 (1 rescuer)Same

Step 5: Attach AED/Monitor and Check Rhythm

  • Shockable (VF/pVT) → Shock + Resume CPR
  • Non-shockable (asystole/PEA) → CPR + Epinephrine

Pediatric Cardiac Arrest Algorithm (PALS)

Non-Shockable (Asystole/PEA):

  1. CPR × 2 minutes
  2. Epinephrine 0.01 mg/kg IV/IO every 3-5 min
  3. Check rhythm every 2 minutes
  4. Identify and treat reversible causes (H's and T's)

Shockable (VF/pVT):

  1. Shock: 2 J/kg (first shock)
  2. CPR × 2 minutes
  3. Shock: 4 J/kg (second shock)
  4. CPR × 2 minutes
  5. Epinephrine 0.01 mg/kg after 2nd shock
  6. Shock: ≥4 J/kg (max 10 J/kg or adult dose)
  7. Amiodarone 5 mg/kg (or Lidocaine 1 mg/kg)
  8. Continue cycles

Epinephrine

RouteDoseFrequency
IV/IO0.01 mg/kg (0.1 mL/kg of 1:10,000)Every 3-5 min
ETT (if no IV/IO)0.1 mg/kg (0.1 mL/kg of 1:1,000)Less reliable

Max dose: 1 mg IV/IO

Antiarrhythmics (For Refractory VF/pVT)

DrugDoseNotes
Amiodarone5 mg/kg IV/IOMax 300 mg first dose; may repeat ×2
Lidocaine1 mg/kg IV/IOAlternative

Defibrillation

ShockEnergy
First2 J/kg
Second4 J/kg
Subsequent≥4 J/kg (max 10 J/kg or adult dose)
  • Use pediatric pads/attenuator if <25lt;25 kg
  • Adult AED can be used if pediatric pads unavailable

Airway Management

Bag-Mask Ventilation:

  • Size-appropriate mask and bag
  • Rate: 1 breath every 2-3 seconds (20-30/min)
  • Watch for chest rise
  • Avoid excessive ventilation

Advanced Airway (ETT or LMA):

  • Once advanced airway placed:
    • Continuous compressions (100-120/min)
    • 1 breath every 2-3 seconds (no pause for ventilation)

ETT Size:

AgeCuffed ETT Size (mm)
Infant3.0-3.5
1-2 years3.5-4.0
> years(Age/4) + 3.5

Vascular Access

PriorityAccess
1stIV access (if already present or quick)
2ndIO access (if IV not obtained in 60-90 seconds)
3rdETT (epinephrine only; less reliable)

IO Sites: Proximal tibia (preferred), distal femur, distal tibia

Reversible Causes (H's and T's)

CauseTreatment
HypoxiaOxygenation, airway management
HypovolemiaFluid bolus 20 mL/kg; blood if trauma
Hydrogen ion (acidosis)Treat underlying cause; consider bicarb if severe
Hypo/HyperkalemiaCalcium, insulin/glucose, or calcium for hyperK
HypothermiaRewarming
HypoglycemiaDextrose 0.5-1 g/kg
Tension pneumothoraxNeedle decompression
TamponadePericardiocentesis
ToxinsSpecific antidotes
Thrombosis (PE/MI)Thrombolytics, ECMO
TraumaDamage control resuscitation

Post-Cardiac Arrest Care

InterventionGoal
OxygenationSpO2 94-99%; avoid hyperoxia
VentilationNormocarbia (PaCO2 35-45)
HemodynamicsMAP > 5th percentile for age; vasopressors PRN
TemperatureTargeted temperature management (avoid hyperthermia; consider hypothermia for coma)
GlucoseAvoid hypo/hyperglycemia
SeizuresTreat promptly
NeuroprognosticationMultidisciplinary; avoid premature WLST

Disposition

ICU Admission

  • All survivors of cardiac arrest
  • ECMO candidacy evaluation
  • Targeted temperature management
  • Neuroprognostication

Declaration of Death

  • After prolonged resuscitation without ROSC
  • Consider duration, rhythm, underlying cause
  • Family communication essential

Consider ECMO (Extracorporeal CPR)

  • Reversible cause (e.g., myocarditis, hypothermia)
  • Witnessed arrest with high-quality CPR
  • ECMO-capable center
  • Discuss early with team

Patient Education

For Family (Post-ROSC)

  • "Your child's heart stopped and we performed CPR to restart it."
  • "We are now focused on protecting the brain and supporting recovery."
  • "We will monitor closely in the ICU and update you regularly."

For Family (After Death)

  • Compassionate communication
  • Offer chaplaincy, social work
  • Consider organ donation if appropriate
  • Discuss autopsy

Special Populations

Infants (<1 Year)

  • Two-finger or two-thumb encircling technique for compressions
  • Higher likelihood of respiratory etiology
  • Use pediatric pads or attenuator for AED

Known Cardiac Disease

  • Higher likelihood of VF/pVT
  • May have pacemaker or ICD
  • Contact cardiology early
  • ECMO consideration

Drowning

  • Prioritize oxygenation and ventilation
  • Hypothermia may be protective—continue resuscitation
  • Consider ECMO

Trauma

  • Hemorrhage control is critical
  • Blood transfusion early
  • Tension pneumothorax, tamponade common
  • Consider thoracotomy in select cases

Quality Metrics

Performance Indicators

MetricTargetRationale
Chest compression fraction>0%Minimize interruptions
Correct compression depthPer guidelinesEffective CPR
Epinephrine within 5 min for non-shockable>0%Early drug administration
Shock within 2 min for shockable>0%Early defibrillation
Post-ROSC temperature management100%Neuroprotection

Documentation Requirements

  • Time of arrest, CPR start
  • Rhythm at each check
  • Epinephrine timing
  • Xtine of shocks
  • ROSC time (if achieved)
  • Post-arrest care

Key Clinical Pearls

Assessment Pearls

  • Pediatric arrest is usually respiratory: Think hypoxia first
  • HR &lt;60lt;60 with poor perfusion = start CPR: Don't wait for pulselessness
  • Shockable rhythms are less common but better outcomes: Get AED/monitor early
  • Check pulse in &lt;10lt;10 seconds: If unsure, start CPR
  • Think H's and T's: Identify reversible causes

Treatment Pearls

  • High-quality CPR saves lives: Push hard, push fast, minimize interruptions
  • Ventilation is critical: Oxygenate and ventilate
  • Epinephrine every 3-5 min: Don't skip doses
  • Amiodarone for refractory VF/pVT: After epinephrine
  • IO if no IV in 60-90 seconds: Fast and reliable
  • Avoid hyperoxia post-ROSC: Titrate to SpO2 94-99%

Disposition Pearls

  • All ROSC patients to ICU: Intensive monitoring
  • Consider ECMO early: For reversible causes
  • Family communication: Keep them informed
  • Don't declare too early: Especially in hypothermia

References
  1. Topjian AA, et al. 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care: Part 4: Pediatric Basic and Advanced Life Support. Circulation. 2020;142(16_suppl_2):S469-S523.
  2. Atkins DL, et al. 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Part 11: Pediatric Basic Life Support and CPR Quality. Circulation. 2015;132(18 Suppl 2):S519-S525.
  3. de Caen AR, et al. 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Part 12: Pediatric Advanced Life Support. Circulation. 2015;132(18 Suppl 2):S526-S542.
  4. Maconochie IK, et al. European Resuscitation Council Guidelines 2021: Paediatric Life Support. Resuscitation. 2021;161:327-387.
  5. Sutton RM, et al. Quantitative analysis of CPR quality during in-hospital resuscitation of older children and adolescents. Pediatrics. 2009;124(2):494-499.
  6. Berg RA, et al. Association Between Diastolic Blood Pressure During Pediatric In-Hospital Cardiopulmonary Resuscitation and Survival. Circulation. 2018;137(17):1784-1795.
  7. Holmberg MJ, et al. Extracorporeal cardiopulmonary resuscitation for pediatric cardiac arrest: A systematic review. Resuscitation. 2019;143:14-28.
  8. UpToDate. Pediatric advanced life support (PALS). 2024.

At a Glance

EvidenceStandard
Last UpdatedRecently

Guidelines

  • NICE Guidelines
  • BTS Guidelines
  • RCUK Guidelines