Pediatric Resuscitation
Critical Alerts
- Pediatric arrest is usually respiratory: Hypoxia leads to bradycardia then arrest
- Ventilation is paramount: Oxygenation and ventilation often reverse bradycardia
- CPR ratio 15:2 for 2 rescuers, 30:2 for single rescuer: Different from adults
- Shockable rhythms (VF/pVT) are less common: But outcomes better when present
- Epinephrine every 3-5 min: 0.01 mg/kg IV/IO (0.1 mL/kg of 1:10,000)
- Defibrillation 2 J/kg → 4 J/kg → ≥4 J/kg: Max 10 J/kg or adult dose
Pediatric Age Definitions
| Age Group | Definition |
|---|---|
| Neonate | <28lt;28 days |
| Infant | <1 yearlt;1 year |
| Child | 1 year to puberty |
| Adolescent | Puberty and beyond (use adult protocols) |
Key Drug Doses
| Drug | Dose | Route |
|---|---|---|
| Epinephrine | 0.01 mg/kg (0.1 mL/kg of 1:10,000) | IV/IO q3-5 min |
| Amiodarone | 5 mg/kg | IV/IO (max 300 mg first dose) |
| Lidocaine | 1 mg/kg | IV/IO |
| Defibrillation | 2 J/kg → 4 J/kg → ≥4 J/kg (max 10 J/kg) | Biphasic |
| Adenosine | 0.1 mg/kg → 0.2 mg/kg | Rapid IV push |
BLS Summary
| Component | Infant (<1 yrlt;1 yr) | Child (1 yr to puberty) |
|---|---|---|
| Compression depth | 1.5 inches (4 cm) | 2 inches (5 cm) |
| Compression rate | 100-120/min | 100-120/min |
| Compression technique | 2 fingers or 2 thumbs | Heel of 1 or 2 hands |
| Rescue breaths | 1 breath every 2-3 sec | 1 breath every 2-3 sec |
| CPR ratio (2 rescuers) | 15:2 | 15:2 |
| CPR ratio (single rescuer) | 30:2 | 30:2 |
Overview
Pediatric cardiac arrest differs from adult arrest in etiology (usually respiratory), rhythm (usually asystole/PEA), and management approach. Pediatric Advanced Life Support (PALS) provides the standardized approach. Prevention of arrest through early recognition and treatment of respiratory failure and shock is critical.
Classification
By Initial Rhythm:
| Rhythm | Incidence | Treatment |
|---|---|---|
| Asystole/PEA | ~90% | CPR + Epinephrine; identify reversible cause |
| VF/pVT | ~10% | CPR + Defibrillation + Epinephrine/Amiodarone |
By Etiology:
| Type | Common Causes |
|---|---|
| Respiratory | Airway obstruction, drowning, asthma, pneumonia, SIDS |
| Circulatory | Septic shock, hypovolemia, trauma |
| Cardiac | Congenital heart disease, arrhythmia, myocarditis |
Epidemiology
- Out-of-hospital pediatric cardiac arrest survival: ~10-15%
- In-hospital pediatric cardiac arrest survival: ~40-50%
- Most common initial rhythm: Asystole/PEA (>80-90%)
- VF/pVT more common in: Congenital heart disease, witnessed arrest, adolescents
Etiology
Common Causes (H's and T's):
| H's | T's |
|---|---|
| Hypoxia (most common) | Tension pneumothorax |
| Hypovolemia | Tamponade (cardiac) |
| Hydrogen ion (acidosis) | Toxins |
| Hypo/Hyperkalemia | Thrombosis (PE, coronary) |
| Hypothermia | Trauma |
| Hypoglycemia |
Respiratory Arrest → Cardiac Arrest
Typical Sequence:
- Respiratory distress (compensated)
- Respiratory failure (decompensated)
- Hypoxia → Bradycardia
- Cardiovascular collapse → Arrest (asystole/PEA)
Why Ventilation Is Key
- Pediatric arrest is usually preceded by hypoxia
- Early oxygenation and ventilation may prevent progression
- Bradycardia often responds to effective ventilation
Cardiac Arrest Without Warning
- Less common in children (vs adults)
- Occurs in: Congenital heart disease, sudden arrhythmia, hypertrophic cardiomyopathy, long QT syndrome
Recognition of Impending Arrest
Pre-Arrest Warning Signs:
| System | Findings |
|---|---|
| Respiratory | Apnea, gasping, severe work of breathing, cyanosis |
| Cardiovascular | Bradycardia <60lt;60, hypotension, poor perfusion |
| Neurological | Unresponsive, limp |
Signs of Cardiac Arrest
Pulse Check (≤10 seconds):
| Age | Location |
|---|---|
| Infant | Brachial or femoral artery |
| Child | Carotid or femoral artery |
High-Risk for Arrest
| Finding | Action |
|---|---|
| HR <60lt;60 with poor perfusion | Start CPR |
| Apnea or agonal breathing | Start rescue breathing/CPR |
| Severe respiratory distress not improving | Prepare for arrest |
| Altered LOC + shock | Aggressive resuscitation |
| Unwitnessed sudden collapse in adolescent | High likelihood VF—get AED/defibrillator |
Pediatric BLS Algorithm
Step 1: Check Responsiveness and Breathing
- Tap and shout
- Look for breathing (5-10 seconds)
Step 2: Call for Help
- Activate emergency response
- Get AED/defibrillator
Step 3: Check Pulse (≤10 seconds)
- If no pulse or unsure → Start CPR
Step 4: CPR
| Parameter | Infant | Child |
|---|---|---|
| Compression depth | 1.5 inches (4 cm) | 2 inches (5 cm) |
| Compression rate | 100-120/min | 100-120/min |
| Allow full chest recoil | Yes | Yes |
| Minimize interruptions | Yes | Yes |
| Compression-to-breath ratio | 15:2 (2 rescuers) or 30:2 (1 rescuer) | Same |
Step 5: Attach AED/Monitor and Check Rhythm
- Shockable (VF/pVT) → Shock + Resume CPR
- Non-shockable (asystole/PEA) → CPR + Epinephrine
Pediatric Cardiac Arrest Algorithm (PALS)
Non-Shockable (Asystole/PEA):
- CPR × 2 minutes
- Epinephrine 0.01 mg/kg IV/IO every 3-5 min
- Check rhythm every 2 minutes
- Identify and treat reversible causes (H's and T's)
Shockable (VF/pVT):
- Shock: 2 J/kg (first shock)
- CPR × 2 minutes
- Shock: 4 J/kg (second shock)
- CPR × 2 minutes
- Epinephrine 0.01 mg/kg after 2nd shock
- Shock: ≥4 J/kg (max 10 J/kg or adult dose)
- Amiodarone 5 mg/kg (or Lidocaine 1 mg/kg)
- Continue cycles
Epinephrine
| Route | Dose | Frequency |
|---|---|---|
| IV/IO | 0.01 mg/kg (0.1 mL/kg of 1:10,000) | Every 3-5 min |
| ETT (if no IV/IO) | 0.1 mg/kg (0.1 mL/kg of 1:1,000) | Less reliable |
Max dose: 1 mg IV/IO
Antiarrhythmics (For Refractory VF/pVT)
| Drug | Dose | Notes |
|---|---|---|
| Amiodarone | 5 mg/kg IV/IO | Max 300 mg first dose; may repeat ×2 |
| Lidocaine | 1 mg/kg IV/IO | Alternative |
Defibrillation
| Shock | Energy |
|---|---|
| First | 2 J/kg |
| Second | 4 J/kg |
| Subsequent | ≥4 J/kg (max 10 J/kg or adult dose) |
- Use pediatric pads/attenuator if <25lt;25 kg
- Adult AED can be used if pediatric pads unavailable
Airway Management
Bag-Mask Ventilation:
- Size-appropriate mask and bag
- Rate: 1 breath every 2-3 seconds (20-30/min)
- Watch for chest rise
- Avoid excessive ventilation
Advanced Airway (ETT or LMA):
- Once advanced airway placed:
- Continuous compressions (100-120/min)
- 1 breath every 2-3 seconds (no pause for ventilation)
ETT Size:
| Age | Cuffed ETT Size (mm) |
|---|---|
| Infant | 3.0-3.5 |
| 1-2 years | 3.5-4.0 |
| > years | (Age/4) + 3.5 |
Vascular Access
| Priority | Access |
|---|---|
| 1st | IV access (if already present or quick) |
| 2nd | IO access (if IV not obtained in 60-90 seconds) |
| 3rd | ETT (epinephrine only; less reliable) |
IO Sites: Proximal tibia (preferred), distal femur, distal tibia
Reversible Causes (H's and T's)
| Cause | Treatment |
|---|---|
| Hypoxia | Oxygenation, airway management |
| Hypovolemia | Fluid bolus 20 mL/kg; blood if trauma |
| Hydrogen ion (acidosis) | Treat underlying cause; consider bicarb if severe |
| Hypo/Hyperkalemia | Calcium, insulin/glucose, or calcium for hyperK |
| Hypothermia | Rewarming |
| Hypoglycemia | Dextrose 0.5-1 g/kg |
| Tension pneumothorax | Needle decompression |
| Tamponade | Pericardiocentesis |
| Toxins | Specific antidotes |
| Thrombosis (PE/MI) | Thrombolytics, ECMO |
| Trauma | Damage control resuscitation |
Post-Cardiac Arrest Care
| Intervention | Goal |
|---|---|
| Oxygenation | SpO2 94-99%; avoid hyperoxia |
| Ventilation | Normocarbia (PaCO2 35-45) |
| Hemodynamics | MAP > 5th percentile for age; vasopressors PRN |
| Temperature | Targeted temperature management (avoid hyperthermia; consider hypothermia for coma) |
| Glucose | Avoid hypo/hyperglycemia |
| Seizures | Treat promptly |
| Neuroprognostication | Multidisciplinary; avoid premature WLST |
ICU Admission
- All survivors of cardiac arrest
- ECMO candidacy evaluation
- Targeted temperature management
- Neuroprognostication
Declaration of Death
- After prolonged resuscitation without ROSC
- Consider duration, rhythm, underlying cause
- Family communication essential
Consider ECMO (Extracorporeal CPR)
- Reversible cause (e.g., myocarditis, hypothermia)
- Witnessed arrest with high-quality CPR
- ECMO-capable center
- Discuss early with team
For Family (Post-ROSC)
- "Your child's heart stopped and we performed CPR to restart it."
- "We are now focused on protecting the brain and supporting recovery."
- "We will monitor closely in the ICU and update you regularly."
For Family (After Death)
- Compassionate communication
- Offer chaplaincy, social work
- Consider organ donation if appropriate
- Discuss autopsy
Infants (<1 Year)
- Two-finger or two-thumb encircling technique for compressions
- Higher likelihood of respiratory etiology
- Use pediatric pads or attenuator for AED
Known Cardiac Disease
- Higher likelihood of VF/pVT
- May have pacemaker or ICD
- Contact cardiology early
- ECMO consideration
Drowning
- Prioritize oxygenation and ventilation
- Hypothermia may be protective—continue resuscitation
- Consider ECMO
Trauma
- Hemorrhage control is critical
- Blood transfusion early
- Tension pneumothorax, tamponade common
- Consider thoracotomy in select cases
Performance Indicators
| Metric | Target | Rationale |
|---|---|---|
| Chest compression fraction | >0% | Minimize interruptions |
| Correct compression depth | Per guidelines | Effective CPR |
| Epinephrine within 5 min for non-shockable | >0% | Early drug administration |
| Shock within 2 min for shockable | >0% | Early defibrillation |
| Post-ROSC temperature management | 100% | Neuroprotection |
Documentation Requirements
- Time of arrest, CPR start
- Rhythm at each check
- Epinephrine timing
- Xtine of shocks
- ROSC time (if achieved)
- Post-arrest care
Assessment Pearls
- Pediatric arrest is usually respiratory: Think hypoxia first
- HR <60lt;60 with poor perfusion = start CPR: Don't wait for pulselessness
- Shockable rhythms are less common but better outcomes: Get AED/monitor early
- Check pulse in <10lt;10 seconds: If unsure, start CPR
- Think H's and T's: Identify reversible causes
Treatment Pearls
- High-quality CPR saves lives: Push hard, push fast, minimize interruptions
- Ventilation is critical: Oxygenate and ventilate
- Epinephrine every 3-5 min: Don't skip doses
- Amiodarone for refractory VF/pVT: After epinephrine
- IO if no IV in 60-90 seconds: Fast and reliable
- Avoid hyperoxia post-ROSC: Titrate to SpO2 94-99%
Disposition Pearls
- All ROSC patients to ICU: Intensive monitoring
- Consider ECMO early: For reversible causes
- Family communication: Keep them informed
- Don't declare too early: Especially in hypothermia
- Topjian AA, et al. 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care: Part 4: Pediatric Basic and Advanced Life Support. Circulation. 2020;142(16_suppl_2):S469-S523.
- Atkins DL, et al. 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Part 11: Pediatric Basic Life Support and CPR Quality. Circulation. 2015;132(18 Suppl 2):S519-S525.
- de Caen AR, et al. 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Part 12: Pediatric Advanced Life Support. Circulation. 2015;132(18 Suppl 2):S526-S542.
- Maconochie IK, et al. European Resuscitation Council Guidelines 2021: Paediatric Life Support. Resuscitation. 2021;161:327-387.
- Sutton RM, et al. Quantitative analysis of CPR quality during in-hospital resuscitation of older children and adolescents. Pediatrics. 2009;124(2):494-499.
- Berg RA, et al. Association Between Diastolic Blood Pressure During Pediatric In-Hospital Cardiopulmonary Resuscitation and Survival. Circulation. 2018;137(17):1784-1795.
- Holmberg MJ, et al. Extracorporeal cardiopulmonary resuscitation for pediatric cardiac arrest: A systematic review. Resuscitation. 2019;143:14-28.
- UpToDate. Pediatric advanced life support (PALS). 2024.