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Dermatology
Plastic Surgery
Primary Care

Pyogenic Granuloma

High EvidenceUpdated: 2025-12-22

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Red Flags

  • Amelanotic melanoma (mimic)
  • Rapidly growing pigmented lesion
Overview

Pyogenic Granuloma

1. Clinical Overview

Summary

Pyogenic granuloma (PG) is a common, benign vascular tumour that presents as a rapidly growing, friable, red nodule that bleeds easily. Despite its name, it is neither pyogenic (no pus) nor a true granuloma — the correct histological term is lobular capillary haemangioma. It typically follows minor trauma and is common in children, young adults, and pregnant women (pregnancy tumour of the gingiva). Common sites include fingers, face, lips, and gums. The main concern is the clinical resemblance to amelanotic melanoma, so histological confirmation is essential. Treatment is curettage and cauterisation; recurrence is common if incompletely excised.

Key Facts

  • Pathology: Lobular capillary haemangioma (NOT pyogenic or granuloma)
  • Appearance: Bright red, friable nodule with collarette of scale; Bleeds easily
  • Sites: Fingers, Face, Lips, Gums (pregnancy)
  • Triggers: Minor trauma, Pregnancy
  • Treatment: Curettage + Cautery; Send for histology
  • Rule Out: Amelanotic melanoma

Clinical Pearls

"Not Pyogenic, Not Granuloma": The name is a misnomer — there is no infection or granulomatous inflammation.

"Bleeds Like Crazy": Profuse bleeding with minor trauma is characteristic.

"Collar of Scale": A collarette of epithelium at the base is a classic finding.

"Always Histology": Never assume a rapidly growing nodule is benign — always send for histology to exclude amelanotic melanoma.


2. Epidemiology

Incidence

  • Very common
  • Accounts for ~0.5% of all skin nodules in children

Demographics

  • All ages; Common in children and young adults
  • F > M (especially in pregnancy)

Risk Factors

FactorNotes
TraumaMinor injury often precedes
Pregnancy"Pregnancy tumour" of gums
MedicationsRetinoids, Indinavir
Port-wine stainCan develop PG within

3. Pathophysiology

Histology

  • Lobular proliferation of capillaries
  • Oedematous stroma
  • Neutrophilic infiltrate (not granulomatous)
  • Collarette of epithelium at base

Why Does It Bleed?

  • Composed of fragile, abnormal capillaries
  • Thin epithelial covering easily disrupted

4. Clinical Presentation

Typical Appearance

FeatureDescription
ColourBright red to dark red
SurfaceGlistening, Raspberry-like, Friable
CollaretteRing of scale at base
SizeUsually 5-10mm; Can grow larger
BleedingProfuse with minor trauma

Common Sites

Symptoms


Fingers (especially nail folds)
Common presentation.
Face (lips, nose)
Common presentation.
Gums (especially in pregnancy)
Common presentation.
Trunk
Common presentation.
5. Clinical Examination

Inspection

  • Red, dome-shaped nodule
  • Glistening surface
  • Collarette of scale at base
  • May be pedunculated (on a stalk)

Palpation

  • Soft, friable
  • Bleeds easily on touch

6. Investigations

Histology (ESSENTIAL)

  • Curettage and cauterisation specimens should be sent for histology
  • Confirms lobular capillary haemangioma
  • Excludes amelanotic melanoma

Dermoscopy

  • Red lacunae (vascular spaces)
  • White rail lines (fibrous septa)
  • Collarette of scale

7. Management

Treatment Options

┌──────────────────────────────────────────────────────────┐
│   PYOGENIC GRANULOMA MANAGEMENT                          │
├──────────────────────────────────────────────────────────┤
│                                                          │
│  FIRST-LINE: CURETTAGE + CAUTERY                          │
│  • Local anaesthetic                                     │
│  • Curettage of lesion                                   │
│  • Cautery to base (reduces recurrence)                  │
│  • SEND FOR HISTOLOGY (essential to exclude melanoma)    │
│                                                          │
│  ALTERNATIVES:                                            │
│  • Excision (especially if diagnosis uncertain)          │
│  • Shave excision + Cautery                              │
│  • Laser ablation (Pulsed dye laser)                     │
│  • Cryotherapy (less effective, higher recurrence)       │
│                                                          │
│  SILVER NITRATE:                                          │
│  • Can be tried but often ineffective                    │
│                                                          │
│  PREGNANCY-RELATED (GINGIVAL):                            │
│  • Often resolves after delivery                         │
│  • Excision if persistent or symptomatic                 │
│                                                          │
│  RECURRENCE:                                              │
│  • Common if incompletely removed                        │
│  • Satellitosis (multiple PG around scar) can occur      │
│                                                          │
└──────────────────────────────────────────────────────────┘

8. Complications

Of Pyogenic Granuloma

  • Profuse bleeding
  • Infection (secondary)
  • Recurrence

Of Treatment

  • Scarring
  • Recurrence (10-40%)
  • Satellitosis (multiple recurrences around scar)

9. Prognosis & Outcomes

With Complete Excision

  • Cure in most cases

Recurrence

  • 10-40% if incompletely removed
  • Satellitosis rare but troublesome

Pregnancy-Related

  • Often resolves spontaneously after delivery

10. Evidence & Guidelines

Key Resources

  1. BAD: Patient Information on Pyogenic Granuloma

Key Evidence

Curettage and Cautery

  • Preferred method; Low recurrence with adequate cauterisation

11. Patient/Layperson Explanation

What is a Pyogenic Granuloma?

A pyogenic granuloma is a small, red, raised lump on the skin that grows quickly and bleeds very easily. Despite its name, it's not caused by an infection.

What Causes It?

Often, it appears after a minor injury. It's also common during pregnancy (especially on the gums).

Is It Serious?

It's not cancer, but it should be removed and checked under a microscope (histology) to make sure it's not something more serious like an unusual type of skin cancer.

How is It Treated?

  • Scraped off (curettage) and burned (cauterised) to stop bleeding and prevent it coming back
  • The removed tissue is sent for testing

Will It Come Back?

Sometimes, especially if not fully removed. Your doctor will advise if this happens.


12. References

Primary Resources

  1. British Association of Dermatologists. Patient Information Leaflet: Pyogenic Granuloma. bad.org.uk

Key Studies

  1. Patrice SJ, et al. Pyogenic granuloma (lobular capillary haemangioma): A clinicopathologic study of 178 cases. Pediatr Dermatol. 1991;8(4):267-276. PMID: 1792196

Last updated: 2025-12-22

At a Glance

EvidenceHigh
Last Updated2025-12-22

Red Flags

  • Amelanotic melanoma (mimic)
  • Rapidly growing pigmented lesion

Clinical Pearls

  • **"Not Pyogenic, Not Granuloma"**: The name is a misnomer — there is no infection or granulomatous inflammation.
  • **"Bleeds Like Crazy"**: Profuse bleeding with minor trauma is characteristic.
  • **"Collar of Scale"**: A collarette of epithelium at the base is a classic finding.
  • **"Always Histology"**: Never assume a rapidly growing nodule is benign — always send for histology to exclude amelanotic melanoma.
  • M (especially in pregnancy)

Guidelines

  • NICE Guidelines
  • BTS Guidelines
  • RCUK Guidelines