Pyogenic Granuloma
Summary
Pyogenic granuloma (PG) is a common, benign vascular tumour that presents as a rapidly growing, friable, red nodule that bleeds easily. Despite its name, it is neither pyogenic (no pus) nor a true granuloma — the correct histological term is lobular capillary haemangioma. It typically follows minor trauma and is common in children, young adults, and pregnant women (pregnancy tumour of the gingiva). Common sites include fingers, face, lips, and gums. The main concern is the clinical resemblance to amelanotic melanoma, so histological confirmation is essential. Treatment is curettage and cauterisation; recurrence is common if incompletely excised.
Key Facts
- Pathology: Lobular capillary haemangioma (NOT pyogenic or granuloma)
- Appearance: Bright red, friable nodule with collarette of scale; Bleeds easily
- Sites: Fingers, Face, Lips, Gums (pregnancy)
- Triggers: Minor trauma, Pregnancy
- Treatment: Curettage + Cautery; Send for histology
- Rule Out: Amelanotic melanoma
Clinical Pearls
"Not Pyogenic, Not Granuloma": The name is a misnomer — there is no infection or granulomatous inflammation.
"Bleeds Like Crazy": Profuse bleeding with minor trauma is characteristic.
"Collar of Scale": A collarette of epithelium at the base is a classic finding.
"Always Histology": Never assume a rapidly growing nodule is benign — always send for histology to exclude amelanotic melanoma.
Incidence
- Very common
- Accounts for ~0.5% of all skin nodules in children
Demographics
- All ages; Common in children and young adults
- F > M (especially in pregnancy)
Risk Factors
| Factor | Notes |
|---|---|
| Trauma | Minor injury often precedes |
| Pregnancy | "Pregnancy tumour" of gums |
| Medications | Retinoids, Indinavir |
| Port-wine stain | Can develop PG within |
Histology
- Lobular proliferation of capillaries
- Oedematous stroma
- Neutrophilic infiltrate (not granulomatous)
- Collarette of epithelium at base
Why Does It Bleed?
- Composed of fragile, abnormal capillaries
- Thin epithelial covering easily disrupted
Typical Appearance
| Feature | Description |
|---|---|
| Colour | Bright red to dark red |
| Surface | Glistening, Raspberry-like, Friable |
| Collarette | Ring of scale at base |
| Size | Usually 5-10mm; Can grow larger |
| Bleeding | Profuse with minor trauma |
Common Sites
Symptoms
Inspection
- Red, dome-shaped nodule
- Glistening surface
- Collarette of scale at base
- May be pedunculated (on a stalk)
Palpation
- Soft, friable
- Bleeds easily on touch
Histology (ESSENTIAL)
- Curettage and cauterisation specimens should be sent for histology
- Confirms lobular capillary haemangioma
- Excludes amelanotic melanoma
Dermoscopy
- Red lacunae (vascular spaces)
- White rail lines (fibrous septa)
- Collarette of scale
Treatment Options
┌──────────────────────────────────────────────────────────┐
│ PYOGENIC GRANULOMA MANAGEMENT │
├──────────────────────────────────────────────────────────┤
│ │
│ FIRST-LINE: CURETTAGE + CAUTERY │
│ • Local anaesthetic │
│ • Curettage of lesion │
│ • Cautery to base (reduces recurrence) │
│ • SEND FOR HISTOLOGY (essential to exclude melanoma) │
│ │
│ ALTERNATIVES: │
│ • Excision (especially if diagnosis uncertain) │
│ • Shave excision + Cautery │
│ • Laser ablation (Pulsed dye laser) │
│ • Cryotherapy (less effective, higher recurrence) │
│ │
│ SILVER NITRATE: │
│ • Can be tried but often ineffective │
│ │
│ PREGNANCY-RELATED (GINGIVAL): │
│ • Often resolves after delivery │
│ • Excision if persistent or symptomatic │
│ │
│ RECURRENCE: │
│ • Common if incompletely removed │
│ • Satellitosis (multiple PG around scar) can occur │
│ │
└──────────────────────────────────────────────────────────┘
Of Pyogenic Granuloma
- Profuse bleeding
- Infection (secondary)
- Recurrence
Of Treatment
- Scarring
- Recurrence (10-40%)
- Satellitosis (multiple recurrences around scar)
With Complete Excision
- Cure in most cases
Recurrence
- 10-40% if incompletely removed
- Satellitosis rare but troublesome
Pregnancy-Related
- Often resolves spontaneously after delivery
Key Resources
- BAD: Patient Information on Pyogenic Granuloma
Key Evidence
Curettage and Cautery
- Preferred method; Low recurrence with adequate cauterisation
What is a Pyogenic Granuloma?
A pyogenic granuloma is a small, red, raised lump on the skin that grows quickly and bleeds very easily. Despite its name, it's not caused by an infection.
What Causes It?
Often, it appears after a minor injury. It's also common during pregnancy (especially on the gums).
Is It Serious?
It's not cancer, but it should be removed and checked under a microscope (histology) to make sure it's not something more serious like an unusual type of skin cancer.
How is It Treated?
- Scraped off (curettage) and burned (cauterised) to stop bleeding and prevent it coming back
- The removed tissue is sent for testing
Will It Come Back?
Sometimes, especially if not fully removed. Your doctor will advise if this happens.
Primary Resources
- British Association of Dermatologists. Patient Information Leaflet: Pyogenic Granuloma. bad.org.uk
Key Studies
- Patrice SJ, et al. Pyogenic granuloma (lobular capillary haemangioma): A clinicopathologic study of 178 cases. Pediatr Dermatol. 1991;8(4):267-276. PMID: 1792196