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Skin Abscess

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Overview

Skin Abscess

Quick Reference

Critical Alerts

  • Incision and drainage (I&D) is primary treatment: Antibiotics alone are insufficient
  • MRSA is common pathogen: Consider in purulent infections
  • Antibiotics adjunct in select cases: Surrounding cellulitis, systemic illness, immunocompromise
  • Rule out necrotizing fasciitis: Disproportionate pain, rapid spread, crepitus
  • Packed wounds may need repacking: Follow-up in 24-48 hours
  • Recurrent abscesses warrant MRSA decolonization consideration

Necrotizing Fasciitis Warning Signs

FindingAction
Severe pain out of proportionUrgent surgical consult
Rapid spreadImaging, surgery
CrepitusCT, emergent surgery
Systemic toxicityResuscitate, broad IV antibiotics, surgery
Skin necrosisEmergent surgery

Emergency Treatments

InterventionDetails
I&DPrimary treatment
PackingFor large cavities
TMP-SMX or DoxycyclineIf adjunct antibiotics indicated
ClindamycinAlternative

Definition

Overview

A skin abscess is a localized collection of pus within the dermis and deeper skin tissues. It is most commonly caused by Staphylococcus aureus, including MRSA. Incision and drainage (I&D) is the primary treatment. Antibiotics are adjunctive in select cases. The key ED task is distinguishing simple abscess from complicated infection (cellulitis, necrotizing fasciitis).

Classification

By Size/Depth:

TypeDescription
Furuncle (boil)Single hair follicle
CarbuncleCluster of furuncles, multiple drainage sites
Simple abscessSingle, localized collection

Epidemiology

  • Very common: ~3% of ED visits are skin/soft tissue infections
  • Rising incidence: Community-acquired MRSA (CA-MRSA)
  • Common sites: Buttocks, groin, axilla, extremities

Etiology

Pathogens:

OrganismNotes
S. aureusMost common; includes MRSA
StreptococcusLess common
PolymicrobialPerianal, groin abscesses
Gram-negativesImmunocompromised, injection drug use

Risk Factors:

FactorNotes
MRSA colonizationPrior CA-MRSA infection
Crowded settingsClose contact, shared equipment
AthletesSkin trauma, shared towels
Injection drug useSkin inoculation
DiabetesImmunocompromise
Poor hygiene

Pathophysiology

Mechanism

  1. Bacterial entry: Through break in skin (folliculitis, trauma, shaving)
  2. Local infection: Bacteria proliferate
  3. Inflammatory response: Neutrophils, localized swelling
  4. Abscess formation: Walled-off pus collection
  5. Fluctuance: Indicates liquid center

Clinical Presentation

Symptoms

FindingDescription
PainTender, throbbing
SwellingLocalized, may be extensive
ErythemaSurrounding redness
WarmthLocal heat
FluctuancePalpable fluid collection
Spontaneous drainageMay occur

History

Key Questions:

Physical Examination

FindingSignificance
Fluctuant massAbscess
Surrounding erythemaCellulitis component
IndurationInflammatory response
LymphadenopathySpread
Fever, tachycardiaSystemic response
CrepitusNecrotizing fasciitis

Duration and progression
Common presentation.
Prior similar infections
Common presentation.
Diabetes or immunocompromise
Common presentation.
Injection drug use
Common presentation.
Recent skin trauma or procedure
Common presentation.
MRSA history
Common presentation.
Red Flags

Necrotizing Fasciitis

FindingAction
Pain out of proportion to appearanceEmergent surgery
Rapid spreadCT, surgery
CrepitusCT, surgery
Skin necrosis, bullaeSurgery
Systemic toxicityResuscitation, IV antibiotics, surgery

Complicated Abscess

FindingConsideration
Large size (> cm)May need antibiotics
Multiple abscessesMRSA; may need antibiotics
Surrounding cellulitisAntibiotics indicated
ImmunocompromisedAntibiotics, close follow-up
Location (face, hand, genitals)Specialist referral

Differential Diagnosis

Other Causes of Skin Swelling

DiagnosisFeatures
CellulitisDiffuse erythema, no fluctuance
Necrotizing fasciitisSevere pain, rapid spread, crepitus
Infected cystHistory of prior cyst
Hidradenitis suppurativaChronic, recurrent, axillae/groin
Infected injection siteIVDU history

Diagnostic Approach

Clinical Diagnosis

  • Abscess is a clinical diagnosis
  • Fluctuance is key finding

Ultrasound

Indications:

  • Differentiating abscess from cellulitis
  • Locating abscess for I&D
  • Assessing size and depth

Findings:

  • Hypoechoic fluid collection
  • Posterior acoustic enhancement

Laboratory

TestIndication
Wound cultureLarge/recurrent abscesses, MRSA concern
CBCSystemic illness
Blood culturesSepsis, endocarditis concern (IVDU)

Treatment

Principles

  1. I&D is primary treatment: Antibiotics alone insufficient
  2. Antibiotics are adjunctive: For select cases
  3. Wound care: Packing, dressing
  4. Follow-up: For wound check, repacking

Incision and Drainage

Technique:

  1. Prep and drape
  2. Local anesthesia (lidocaine; field block or infiltration)
  3. Incise over fluctuant area (stab incision or full incision)
  4. Express pus completely
  5. Break up loculations (hemostat or finger)
  6. Irrigate with saline
  7. Pack wound (if large cavity)
  8. Dress wound

Packing:

  • Indicated for cavities >1 cm
  • Iodoform or plain gauze
  • Remove/replace in 24-48 hours

Antibiotics (When Indicated)

Indications:

IndicationNotes
Surrounding cellulitis> cm
Systemic symptoms (fever)
ImmunocompromisedDiabetes, HIV
Multiple abscesses
High-risk location (face, hand)
No improvement after I&D

First-Line (MRSA Coverage):

AgentDoseDuration
TMP-SMX DS1-2 tabs BID5-7 days
Doxycycline100 mg BID5-7 days
Clindamycin300-450 mg TID5-7 days

For Strep Coverage (If Needed):

  • Add amoxicillin or amoxicillin-clavulanate

Analgesia

AgentDose
Acetaminophen650-1000 mg q6h
Ibuprofen400-600 mg q6h
Opioids (short-term)If severe pain

Disposition

Discharge Criteria

  • Successful I&D
  • No systemic illness
  • Able to perform wound care or have follow-up for repacking
  • Reliable follow-up

Admission Criteria

  • Necrotizing fasciitis concern
  • Extensive cellulitis
  • Sepsis
  • Failed outpatient I&D
  • Immunocompromised with severe infection
  • Facial abscess with concern for spread

Referral

IndicationReferral
Perirectal/Perianal abscessSurgery
Facial abscess near eyes/midfaceENT or surgery
Breast abscessSurgery or OB
Pilonidal abscessSurgery
Recurrent hidradenitisDermatology, surgery

Follow-Up

SituationFollow-Up
Packed wound24-48 hours for repacking
UncomplicatedPCP in 1-2 weeks
RecurrentConsider MRSA decolonization

Patient Education

Condition Explanation

  • "You have a skin abscess, which is a pocket of pus under the skin."
  • "The best treatment is to drain it, which we did."
  • "You may need antibiotics to help prevent the infection from spreading."

Wound Care

  • Keep dressing clean and dry
  • Return for packing removal/change in 24-48 hours
  • Warm compresses may help
  • Take antibiotics as directed (if prescribed)

Prevention (MRSA)

  • Don't share towels, razors, or personal items
  • Keep cuts and scrapes clean and covered
  • Wash hands frequently
  • Consider bleach baths (1/4 cup bleach to full bathtub) if recurrent

Warning Signs to Return

  • Fever
  • Increasing redness or swelling
  • Pain getting worse
  • Red streaks spreading
  • Not improving in 48 hours

Special Populations

Diabetes

  • Higher infection risk
  • Consider antibiotics even for simple abscess
  • Close follow-up

Immunocompromised

  • Broader antibiotic coverage
  • Lower threshold for admission
  • Consider atypical pathogens

Injection Drug Users

  • Consider endocarditis if bacteremia
  • Blood cultures if febrile
  • Screen for HIV, hepatitis

Recurrent Abscesses

  • Consider MRSA decolonization
  • Mupirocin nasal ointment × 5 days
  • Bleach baths
  • Chlorhexidine washes

Quality Metrics

Performance Indicators

MetricTargetRationale
I&D performed for abscess100%Primary treatment
Wound culture for recurrent/large>0%Guide therapy
Antibiotic only when indicated>0%Stewardship
Follow-up arranged for packed wounds100%Wound care

Documentation Requirements

  • Size of abscess
  • Amount of purulent drainage
  • Presence of cellulitis
  • Wound packing
  • Antibiotic prescribed (if any)
  • Follow-up plan

Key Clinical Pearls

Diagnostic Pearls

  • Fluctuance = Abscess: Needs I&D
  • Ultrasound if uncertain: Differentiates abscess from cellulitis
  • Pain out of proportion = Necrotizing fasciitis: Emergency
  • Recurrent abscesses suggest MRSA colonization
  • Perirectal abscess needs surgical evaluation

Treatment Pearls

  • I&D is primary treatment: Antibiotics alone don't work
  • Pack large cavities: Prevents premature closure
  • TMP-SMX or doxycycline for MRSA coverage: If antibiotics needed
  • Antibiotics NOT needed for simple, uncomplicated abscess
  • Warm compresses promote drainage

Disposition Pearls

  • Most can be discharged: After I&D
  • Follow-up for packing removal: 24-48 hours
  • Admit for nec fasc, sepsis, or extensive infection
  • MRSA decolonization for recurrent cases

References
  1. Stevens DL, et al. Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections. Clin Infect Dis. 2014;59(2):e10-e52.
  2. Daum RS. Skin and Soft-Tissue Infections Caused by Methicillin-Resistant Staphylococcus aureus. N Engl J Med. 2007;357(4):380-390.
  3. Talan DA, et al. Trimethoprim-Sulfamethoxazole versus Placebo for Uncomplicated Skin Abscess. N Engl J Med. 2016;374(9):823-832.
  4. Singer AJ, et al. Comparison of wound packing to no wound packing following incision and drainage of superficial skin abscesses. Ann Emerg Med. 2016;66(2):130-136.
  5. Taira BR, et al. Prospective randomized trial on packing versus no packing after drainage of subcutaneous cutaneous abscess. J Emerg Med. 2018;55(6):755-761.
  6. IDSA Guidelines. Skin and soft tissue infections. 2014.
  7. CDC. MRSA in Healthcare Settings. 2024.
  8. UpToDate. Skin abscesses, furuncles, and carbuncles. 2024.

At a Glance

EvidenceStandard
Last UpdatedRecently

Guidelines

  • NICE Guidelines
  • BTS Guidelines
  • RCUK Guidelines