Summary
Acute abdomen refers to sudden onset of severe abdominal pain requiring urgent evaluation and potential surgical intervention. It represents a spectrum of conditions ranging from self-limited disorders to life-threatening surgical emergencies. Key causes include appendicitis, cholecystitis, bowel obstruction, perforated viscus, and mesenteric ischaemia. Early recognition of surgical emergencies, systematic assessment, and appropriate imaging (CT abdomen/pelvis is gold standard) are essential. Life-threatening conditions such as ruptured AAA, mesenteric ischaemia, and ruptured ectopic pregnancy must be excluded promptly.
Key Facts
- Definition: Sudden severe abdominal pain requiring urgent evaluation
- Most common causes: Appendicitis, cholecystitis, bowel obstruction
- Life-threatening: Ruptured AAA, mesenteric ischaemia, perforated viscus
- Key investigation: CT abdomen/pelvis with IV contrast
- Mandatory test: Pregnancy test in all reproductive-age females
- Key marker: Lactate (greater than 2 concerning for ischaemia)
Clinical Pearls
Pain Out of Proportion: Severe pain with minimal abdominal findings = mesenteric ischaemia until proven otherwise. This is the key warning sign for bowel ischaemia.
Pregnancy Test First: In all reproductive-age females with abdominal pain, exclude ectopic pregnancy before any other diagnosis.
Analgesia Does NOT Mask: Do not withhold analgesia — it does not mask peritoneal signs or delay diagnosis. Early pain relief is evidence-based and appropriate.
Why This Matters Clinically
Acute abdomen is a common ED presentation with potential for catastrophic outcomes if life-threats are missed. Ruptured AAA, mesenteric ischaemia, and perforated viscus have mortality rates of 50-80% without prompt treatment. Systematic evaluation with early surgical consultation saves lives.
(Epidemiological data integrated into differential diagnosis below)
Pain Mechanisms
Visceral Pain
- Originates from distention, inflammation, or ischemia of hollow organs
- Poorly localized, midline, dull, crampy
- Often associated with autonomic symptoms (nausea, vomiting, diaphoresis)
- Referred to dermatomal distribution of organ's innervation
Parietal (Somatic) Pain
- Results from irritation of parietal peritoneum
- Well-localized, sharp, constant
- Worsened by movement, coughing
- Indicates progression of disease process
Referred Pain
- Perceived at location distant from source
- Follows embryological nerve distribution
- Examples: Right shoulder pain in cholecystitis (phrenic nerve)
Peritoneal Irritation
Chemical Peritonitis
- Gastric acid (perforated ulcer)
- Bile (gallbladder perforation)
- Pancreatic enzymes (acute pancreatitis)
- Blood (hemoperitoneum)
Bacterial Peritonitis
- Appendiceal or diverticular perforation
- Bowel perforation from any cause
- Spontaneous bacterial peritonitis in ascites
Step 1: Visceral Pain (The Early Warning)
- Mechanism: Stretch receptors in the walls of hollow viscus organs (gut, ureter, bile duct) or capsule stretching (liver, spleen).
- Conduction: C-fibers (slow, unmyelinated). Bilateral innervation.
- Character: Dull, aching, gnawing, cramping, poorly localized.
- Location:
- Foregut (Stomach/Pancreas): Epigastric.
- Midgut (Small Bowel/Appendix): Periumbilical.
- Hindgut (Colon): Suprapubic.
- Autonomic: Often accompanied by nausea, vomiting, sweating (embryological reflex).
Step 2: Somatic (Parietal) Pain (The Danger Signal)
- Mechanism: Irritation of the parietal peritoneum by pus, bile, acid, or blood.
- Conduction: A-delta fibers (fast, myelinated). Unilateral innervation.
- Character: Sharp, stabbing, intense, constant, well-localized.
- Pointers: Aggravated by movement, cough (Dunphy's sign), or vibration (bumps in the car).
- Migration: The classic shift in appendicitis (Visceral -> Somatic) represents the inflammation moving from the appendix lumen to the serosa touching the abdominal wall.
Step 3: Referred Pain (The Mask)
- Mechanism: Convergence of somatic and visceral afferents on the same spinal cord segment. The brain misinterprets the visceral signal as coming from the somatic dermatome.
- Examples:
- Diaphragm (C3-C5) -> Shoulder Tip (Kehr's Sign).
- Ureter (T11-L2) -> Groin/Testicle.
- Gallbladder (T7-T9) -> Right Scapula (Boas' Sign).
Step 4: The Peritoneal Response (Peritonitis)
- Inflammation: Release of histamine, bradykinin, serotonin causes vasodilation and increased permeability.
- Exudation: Fibrinogen-rich fluid pours into the cavity, causing "loops of bowel to stick together" (walling off).
- Paralysis: Inflamed bowel stops contracting -> Paralytic Ileus (Silent abdomen).
- Rigidity: Reflex spasm of abdominal muscles to protect the inflamed peritoneum (Involuntary Guarding).
Vascular Pathophysiology
Mesenteric Ischemia Progression
- Initial mucosal ischemia (reversible)
- Full-thickness infarction
- Bacterial translocation
- Sepsis and multi-organ failure
- Death if untreated (mortality 60-80%)
AAA Rupture Hemodynamics
- Retroperitoneal tamponade may temporarily stabilize
- Contained rupture allows time for intervention
- Free rupture leads to rapid exsanguination
History Elements
Pain Characteristics (OPQRST)
| Component | Key Questions | Significance |
|---|---|---|
| Onset | Sudden vs gradual | Sudden: perforation, AAA, ectopic |
| Provocation | Movement, eating, position | Peritonitis worsened by movement |
| Quality | Sharp, crampy, constant | Colicky: obstruction; Sharp: peritonitis |
| Radiation | Back, shoulder, groin | Back: AAA, pancreatitis; Shoulder: diaphragm |
| Severity | Pain scale | Pain out of proportion: ischemia |
| Timing | Duration, progression | Rapid progression concerning |
Associated Symptoms
Critical History
Physical Examination
General Appearance
Vital Signs Patterns
| Finding | Suggests |
|---|---|
| Fever | Infection, inflammation |
| Tachycardia | Pain, hypovolemia, sepsis |
| Hypotension | Hemorrhage, sepsis, dehydration |
| Tachypnea | Acidosis, pain, diaphragm irritation |
Abdominal Examination
Critical Signs
Additional Examination
Comprehensive assessment requires a systematic approach to identify peritoneal signs and localized pathology.
General Inspection
- The "End of Bed" Test:
- Patient lying still? -> Peritonitis (movement hurts).
- Patient writhing/rolling? -> Visceral Colic (Renal stone, Bowel obstruction).
- Pallor/Sweating? -> Shock.
Abdominal Examination
1. Inspection
- Scars: Previous surgery = Adhesions = Obstruction.
- Distension: The 5 F's (Fat, Fluid, Flatus, Feces, Fetus).
- Ecchymosis: Cullen's (Umbilicus), Grey Turner's (Flanks) = Retroperitoneal Bleed (Pancreatitis/AAA).
- Visible Peristalsis: Obstruction.
2. Palpation (The Money Maker)
- Rule 1: Ask the patient to point to where it hurts most. Start away from this spot.
- Superficial: Check for "Board-like Rigidity" (Involuntary guarding).
- Deep: Assess for masses (AAA, Appendix mass).
- Tenderness: Map the maximum point of tenderness.
3. Percussion
- Tympany: Gas-filled loops (Obstruction).
- Loss of Liver Dullness: Free gas (Perforation).
- Shifting Dullness: Ascites.
- Percussion Tenderness: The kindest way to test for peritonitis (instead of Rebound).
4. Auscultation
- Absent: "Silent Abdomen" -> Peritonitis / Ileus.
- Tinkling: High-pitched "plinking" sounds -> Obstruction.
- Bruit: Renal/Aortic.
Special Tests & Eponyms
- Murphy's Sign: Arrest of inspiration on RUQ palpation (Cholecystitis).
- Rovsing's Sign: Palpation in LLQ causes pain in RLQ (Appendicitis).
- Psoas Sign: Pain on extension of right hip (Retrocaecal Appendix).
- Obturator Sign: Pain on internal rotation of right hip (Pelvic Appendix).
- Carnett's Test: Tensing abdominal muscles (sit-up). Increased pain = Abdominal Wall. Decreased pain = Visceral.
The "Forgotten" Exams
- Hernial Orifices: Femoral/Inguinal. Incarceration is rare but easily fixed if found.
- Testicular Exam: Torsion presents as "lower abdo pain".
- PR Exam: Only if suspecting GI bleed (Melena), Prostatic abscess, or distal obstruction.
Red Flags
Immediate Life Threats
| Condition | Key Features | Immediate Action |
|---|---|---|
| Ruptured AAA | >0 years, sudden back/abdominal pain, pulsatile mass, hypotension | Massive transfusion, vascular surgery STAT |
| Mesenteric ischemia | AF, cardiovascular disease, pain > exam findings, metabolic acidosis | CT angiography, anticoagulation, surgery |
| Ruptured ectopic | Reproductive age female, missed period, + pregnancy test, hemodynamic instability | Blood transfusion, emergent surgery |
| Perforated viscus | Sudden severe pain, rigid abdomen, free air on imaging | Surgical consultation, antibiotics |
| Bowel strangulation | Obstruction with fever, tachycardia, localized tenderness, lactate elevation | Emergent surgery |
High-Risk Clinical Scenarios
Immunocompromised Patients
- Blunted inflammatory response
- May have minimal findings despite significant pathology
- Lower threshold for imaging and admission
Elderly Patients
- Atypical presentations common
- Higher mortality from same conditions
- May lack fever or peritoneal signs
- Pain often underestimated
Anticoagulated Patients
- Higher risk of hemorrhage
- Lower threshold for imaging
- Consider retroperitoneal hematoma
Post-surgical Patients
- Consider anastomotic leak
- Internal hernia (especially post-bariatric)
- Adhesive obstruction
Differential Diagnosis by Location
Right Upper Quadrant
| Condition | Key Features |
|---|---|
| Cholecystitis | Murphy's sign, fever, RUQ tenderness |
| Hepatitis | Jaundice, transaminitis |
| Liver abscess | Fever, RUQ pain, systemic illness |
| Perforated duodenal ulcer | Sudden onset, peritonitis |
| Right lower lobe pneumonia | Cough, fever, abnormal lung exam |
| Fitz-Hugh-Curtis | Young female, PID history |
Right Lower Quadrant
| Condition | Key Features |
|---|---|
| Appendicitis | Migration of pain, anorexia, fever |
| Ectopic pregnancy | Reproductive age, + pregnancy test |
| Ovarian torsion | Sudden onset, adnexal tenderness |
| Ruptured ovarian cyst | Mid-cycle, sudden pain |
| Crohn's disease flare | Known IBD, diarrhea |
| Mesenteric adenitis | Viral symptoms, younger patient |
| Psoas abscess | Flexed hip, fever |
Left Upper Quadrant
| Condition | Key Features |
|---|---|
| Splenic pathology | Trauma history, Kehr's sign |
| Gastric ulcer | Epigastric pain, melena |
| Pancreatitis | Epigastric radiating to back, elevated lipase |
| Left lower lobe pneumonia | Cough, fever, chest findings |
Left Lower Quadrant
| Condition | Key Features |
|---|---|
| Diverticulitis | Age >0, LLQ tenderness, fever |
| Sigmoid volvulus | Elderly, constipation, massive distention |
| Ectopic pregnancy | As above |
| Ovarian pathology | As above |
| IBD flare | Known history, bloody diarrhea |
Diffuse/Periumbilical
| Condition | Key Features |
|---|---|
| Small bowel obstruction | Vomiting, distention, prior surgery |
| Mesenteric ischemia | AF, pain > exam |
| Ruptured AAA | Elderly, sudden, back pain |
| Pancreatitis | Epigastric, radiating to back |
| Gastroenteritis | Vomiting, diarrhea, contacts |
Suprapubic
| Condition | Key Features |
|---|---|
| Urinary retention | Distended bladder, unable to void |
| UTI/pyelonephritis | Dysuria, CVA tenderness |
| PID | Cervical motion tenderness, discharge |
Extra-Abdominal Causes
Cardiopulmonary
- Inferior myocardial infarction
- Pulmonary embolism
- Lower lobe pneumonia
- Empyema
Metabolic
- Diabetic ketoacidosis
- Addisonian crisis
- Acute porphyria
- Lead poisoning
Other
- Herpes zoster (pre-vesicular)
- Abdominal wall pathology
- Rectus sheath hematoma
Diagnostic Approach
Immediate Assessment
Primary Survey
- Airway patency
- Breathing adequacy
- Circulation (pulses, BP, perfusion)
- Disability (neurologic status)
- Exposure (complete examination)
Rapid Risk Stratification
- Hemodynamically unstable: emergent surgical consultation
- Peritoneal signs: surgical consultation
- High-risk features: expedited workup
Laboratory Studies
Essential Tests
| Test | Purpose | Critical Values |
|---|---|---|
| CBC | Leukocytosis, anemia | WBC >5k or left shift |
| BMP | Electrolytes, renal function | Elevated BUN/Cr, acidosis |
| Lipase | Pancreatitis | >x upper limit |
| LFTs | Hepatobiliary disease | Elevated with cholecystitis |
| Lactate | Tissue perfusion | >2 concerning, > critical |
| Pregnancy test | All reproductive females | Must exclude ectopic |
| Type and screen | Potential transfusion | For all surgical candidates |
| Coagulation studies | If anticoagulated, surgery anticipated | INR elevation |
| Urinalysis | UTI, hematuria | RBCs, WBCs |
Extended Testing
- Blood cultures: If sepsis suspected
- Amylase: Less specific than lipase
- D-dimer: If PE considered
- Troponin: If inferior MI considered
Imaging Studies
Plain Radiography
- Upright chest X-ray: Free air under diaphragm (perforation)
- Abdominal series: Obstruction patterns, calcifications
Ultrasonography
- Point-of-care (POCUS):
- AAA screening
- Free intraperitoneal fluid
- Gallbladder assessment
- IVC for volume status
- Formal ultrasound: RUQ, pelvic, testicular
CT Abdomen/Pelvis
- Gold standard for acute abdominal evaluation
- IV contrast for vascular enhancement
- Oral contrast generally not needed in emergent settings
- Alternative protocols for renal impairment, allergy
CT Angiography
- Suspected mesenteric ischemia
- Suspected AAA rupture (if stable enough)
MRI
- Avoid in acute setting unless CT contraindicated
- May be useful for pregnant patients (after first trimester)
Diagnostic Algorithm
Acute Abdominal Pain
↓
Hemodynamically Unstable?
↓
Yes → Immediate resuscitation
Emergent surgical consultation
Bedside ultrasound (AAA, free fluid)
Consider OR without CT
↓
No → Continue evaluation
↓
Peritoneal Signs Present?
↓
Yes → Surgical consultation
CT abdomen/pelvis (if stable)
Broad-spectrum antibiotics
↓
No → Focused workup based on
location and presentation
↓
CT abdomen/pelvis with IV contrast
(or targeted ultrasound)
↓
Diagnosis made → Condition-specific treatment
Diagnosis unclear → Consider observation, serial exams
Initial Resuscitation
Hemodynamically Unstable Patient
Step 1: Vascular access
- Two large-bore IVs (16-18G)
- Consider central venous access if peripheral difficult
- Prepare for massive transfusion if hemorrhage suspected
Step 2: Volume resuscitation
- Crystalloid bolus (1-2L warm normal saline)
- Blood products if hemorrhagic shock
- Goal: MAP >65, urine output >0.5 mL/kg/hr
Step 3: NPO status
- Insert NG tube for decompression if obstruction/vomiting
- Prepare for emergent surgery
Management Algorithm
Acute Abdominal Pain
↓
┌───────────────────────────────────────────────┐
│ IMMEDIATE RESUSCITATION │
│ - ABCDE Assessment │
│ - IV Access, Fluid Resuscitation │
│ - Analgesia (Opioids do NOT mask signs!) │
│ - PREGNANCY TEST (Females under 55y) │
└───────────────────────────────────────────────┘
↓
┌───────────────────────────────────────────────┐
│ HEMODYNAMIC STATUS? │
├──────────────────────┬────────────────────────┤
│ UNSTABLE │ STABLE │
│ (Shock / Peritonitis)│ │
├──────────────────────┼────────────────────────┤
│ ↓ │ ↓ │
│ Straight to Theatre │ Detailed History │
│ (Laparotomy) │ & Examination │
│ OR │ ↓ │
│ Bedside Ultrasound │ Blood Tests (Lactate)│
│ (Ruptured AAA?) │ ↓ │
└──────────────────────┤ CT Abdomen/Pelvis │
│ (Gold Standard) │
└───────────┬────────────┘
↓
┌────────────────────────┐
│ DISPOSITION │
│ - Surgical Admission │
│ - Medical Admission │
│ - Discharge (Review) │
└────────────────────────┘
Acute/Emergency Management
1. The "Resuscitate Before Diagnosis" Phase
- Access: 2x Large bore cannulae.
- Fluids: Hartmann's solution (avoid saline due to acidosis risk).
- Analgesia: Morphine 10mg IV / Fentanyl 100mcg. Myth Buster: Analgesia makes the patient cooperative and exam reliable. It does NOT mask peritonitis.
- Antiemetics: Ondansetron 4-8mg.
2. The "Sepsis Six" (If Septic)
- Oxygen.
- Blood Cultures.
- IV Antibiotics (Broad spectrum, e.g., Amoxicillin + Gentamicin + Metronidazole).
- Fluid Challenge.
- Lactate measurement.
- Urine Output monitoring.
Analgesia
Pain Management Principles
- Analgesia does NOT mask peritoneal signs or delay diagnosis
- Early pain control is appropriate and evidence-based
- IV route preferred for rapid onset
Medications
| Medication | Dose | Notes |
|---|---|---|
| Morphine | 0.1 mg/kg IV | Titrate to effect |
| Fentanyl | 1-2 mcg/kg IV | Shorter acting, less histamine release |
| Hydromorphone | 0.5-1 mg IV | Alternative to morphine |
| Ketorolac | 15-30 mg IV | Avoid if surgical, renal disease, GI bleed risk |
Antimicrobial Therapy
Indications
- Suspected perforation
- Peritonitis
- Cholecystitis, cholangitis
- Appendicitis
- Diverticulitis
- Sepsis
Empiric Regimens
| Severity | Regimen |
|---|---|
| Mild-moderate community acquired | Ceftriaxone 2g IV + Metronidazole 500mg IV |
| Severe/sepsis | Piperacillin-tazobactam 4.5g IV OR Meropenem 1g IV |
| Healthcare-associated | Meropenem 1g IV + Vancomycin (if MRSA risk) |
| Penicillin allergy | Ciprofloxacin 400mg IV + Metronidazole 500mg IV |
Surgical Consultation
Emergent (Immediate) Consultation
- Ruptured AAA
- Peritonitis
- Hemorrhagic shock
- Bowel ischemia/necrosis
Urgent Consultation
- Appendicitis
- Cholecystitis
- Small bowel obstruction
- Strangulated hernia
- Perforated viscus
Condition-Specific Management
Appendicitis
- NPO, IV fluids
- Antibiotics (ceftriaxone + metronidazole)
- Surgical consultation for appendectomy
Cholecystitis
- NPO, IV fluids
- Antibiotics
- Surgical consultation for cholecystectomy
- Percutaneous cholecystostomy if high surgical risk
Small Bowel Obstruction
- NPO, NG decompression
- IV fluids
- Surgical consultation
- Surgery if signs of strangulation or no improvement in 24-48 hours
Diverticulitis
- Uncomplicated: May be outpatient with oral antibiotics
- Complicated (abscess, perforation): Admission, IV antibiotics, drainage, possible surgery
Disposition
ICU Admission
- Hemodynamic instability
- Septic shock
- Massive transfusion requirement
- Post-operative monitoring for complex cases
- Multiorgan failure
Surgical Ward Admission
- Confirmed surgical pathology
- Peritonitis
- Bowel obstruction
- Acute pancreatitis (moderate-severe)
- Cholecystitis/cholangitis
Medical Ward Admission
- Diagnostic uncertainty requiring observation
- Mild-moderate pancreatitis
- Uncomplicated diverticulitis in high-risk patient
- Elderly with concerning exam
Discharge Criteria
Safe for Outpatient Management
- Stable vital signs
- Benign abdominal examination
- Tolerate oral intake
- Reliable follow-up available
- Clear diagnosis with outpatient treatment plan
- No concerning laboratory abnormalities
Appropriate for Discharge
- Uncomplicated diverticulitis (low-risk patient)
- Mild gastroenteritis
- Constipation
- Musculoskeletal pain
- Viral syndromes
Follow-up Recommendations
| Condition | Follow-up Timeline |
|---|---|
| Observation discharge | 12-24 hours with PCP |
| Uncomplicated diverticulitis | 2-3 days with PCP, colonoscopy later |
| Kidney stone | Urology within 1-2 weeks |
| Ovarian cyst | Ob/Gyn within 1 week |
| Abdominal wall pain | PCP within 1 week |
Return Precautions
Strict Return Instructions
- Worsening or severe pain
- Fever >101°F (38.3°C)
- Vomiting and unable to keep fluids down
- Blood in stool or vomit
- Fainting or severe dizziness
- Abdominal distention
- No bowel movements with worsening symptoms
Pediatric Considerations
- Appendicitis remains common
- Intussusception in young children
- Malrotation with volvulus (neonate through infant)
- Limited history from young children
- Consider child abuse with unexplained injury
Geriatric Patients
High-Risk Features
- Presentations often atypical
- May lack fever, leukocytosis, peritoneal signs
- Higher mortality from equivalent conditions
- Consider bowel ischemia early
- AAA more common
Management Modifications
- Lower threshold for imaging
- Earlier surgical consultation
- Consider limited life expectancy in decision-making
- Involve family/caregivers in disposition planning
Pregnancy
Special Considerations
- Ectopic pregnancy until proven otherwise
- Appendicitis most common surgical emergency
- Appendix displaced superiorly by gravid uterus
- Avoid CT if possible (use MRI or US)
- Consider obstetric consultation early
Modified Imaging Approach
- Ultrasound first-line
- MRI without gadolinium if ultrasound inconclusive
- CT if life-threatening condition suspected
Immunocompromised Patients
- Opportunistic infections possible
- Neutropenic enterocolitis (typhlitis)
- Muted inflammatory response
- Lower threshold for broad-spectrum antibiotics
- Consider CMV, fungal infections
Performance Indicators
| Metric | Target |
|---|---|
| Time to initial assessment | within 15 minutes |
| Pregnancy test in reproductive-age females | 100% |
| Time to surgical consultation (acute abdomen) | within 60 minutes |
| Appropriate imaging obtained | >5% |
| Pain assessment documented | 100% |
| Analgesia provided when appropriate | >0% |
Documentation Requirements
- Complete vital signs including temperature
- Pregnancy test result (reproductive-age females)
- Detailed abdominal examination
- Risk stratification and reasoning
- Treatment provided (fluids, analgesia, antibiotics)
- Disposition rationale
- Clear follow-up instructions
Key Clinical Pearls
Critical Decision Points
- Never delay surgical consultation for hemodynamically unstable patients with suspected surgical abdomen
- Pregnancy test first in all reproductive-age females with abdominal pain
- Pain out of proportion to exam = mesenteric ischemia until proven otherwise
- Elderly and immunocompromised may have minimal findings with severe pathology
- Free air on upright CXR = surgical emergency
Diagnostic Pearls
- Always check hernia orifices - incarcerated hernia is easy to miss
- Right shoulder pain with RUQ tenderness suggests diaphragmatic irritation (cholecystitis, perforated ulcer)
- Lactate >4 in abdominal pain suggests tissue ischemia or necrosis
- Oral contrast is rarely needed emergently for CT
- Serial abdominal exams remain valuable when diagnosis unclear
Management Pearls
- Analgesia does not mask surgical findings - provide early pain relief
- NG decompression helps with nausea/vomiting but doesn't change obstruction management timeline
- Broad-spectrum antibiotics before surgery in suspected perforation/peritonitis
- When in doubt, consult surgery early rather than late
- Observation admission is appropriate if diagnosis uncertain and patient appears unwell
Understanding Acute Abdominal Pain
- Many causes of abdominal pain are not serious
- Some conditions require close monitoring or surgery
- Follow-up is important even if discharged
Post-Discharge Care
General Instructions
- Take prescribed medications as directed
- Maintain hydration
- Follow dietary recommendations (if given)
- Activity as tolerated unless otherwise instructed
When to Return
- Worsening pain despite medications
- New symptoms (fever, vomiting, blood)
- Unable to keep food/fluids down
- No improvement in 24-48 hours
Condition-Specific Education
After Bowel Rest
- Clear liquids first
- Advance diet slowly
- Avoid heavy, fatty foods initially
Post-Surgical Instructions
- Wound care
- Activity restrictions
- Signs of complications
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