Viral Conjunctivitis
Summary
Viral Conjunctivitis is an acute inflammation of the conjunctiva caused by a viral infection, most commonly Adenovirus. It is highly contagious and typically presents with a watery (serous) discharge, conjunctival injection (red eye), and gritty discomfort. It often starts unilaterally and spreads to the other eye within days. Patients commonly have a history of recent Upper Respiratory Tract Infection (URTI) or contact with someone with pink eye. The condition is self-limiting, usually resolving within 2-3 weeks. Management is supportive (lubricants, hygiene, no antibiotics). It is critical to exclude Herpes Simplex Virus (HSV) keratitis (Dendritic Ulcer) in patients with vesicular rash, recurrent episodes, or unilateral pain/photophobia.
Key Facts
- Most Common Cause: Adenovirus.
- Transmission: Highly contagious. Direct contact, Fomites.
- Presentation: Watery discharge, Red eye, Gritty sensation, Pre-auricular lymphadenopathy.
- Associations: Recent URTI, Contact with infected person, Outbreaks (Schools, Pools).
- Course: Worsens over 3-5 days, resolves in 2-3 weeks.
- Treatment: Supportive (Lubricants, Hygiene). NO Antibiotics.
- Red Flag: Severe pain/photophobia -> Consider HSV Keratitis.
Clinical Pearls
"Watery = Viral, Purulent = Bacterial": Viral conjunctivitis produces a watery (serous) discharge. Thick purulent (yellow-green) discharge suggests bacterial infection.
"Pre-Auricular Lymph Nodes": Palpable pre-auricular lymph nodes are characteristic of viral (especially adenoviral) conjunctivitis.
"ALWAYS Exclude HSV": If there is vesicular rash, severe photophobia, recurrent unilateral eye disease, or dendritic ulcer on slit lamp -> Suspect HSV. Never give steroids without excluding HSV.
"No Antibiotics": Viral conjunctivitis is self-limiting. Antibiotic drops do not help and contribute to resistance.
Why This Matters Clinically
Viral conjunctivitis is extremely common and highly contagious. Recognising it avoids unnecessary antibiotic prescriptions. However, missing HSV keratitis can lead to blindness.
Incidence
- Very Common: Accounts for ~80% of acute conjunctivitis.
- Age: All ages. Common in children.
- Outbreaks: Schools, Swimming pools, Families.
- Seasonal: Often autumn/winter (coincides with URTI season).
Causative Organisms
| Organism | Notes |
|---|---|
| Adenovirus (Most Common) | Serotypes 3, 4, 7 (PCF). 8, 19, 37 (EKC – Epidemic Keratoconjunctivitis). |
| Herpes Simplex Virus (HSV) | Vesicular lid lesions. Dendritic ulcer. Recurrent. |
| Varicella Zoster Virus (VZV) | Herpes Zoster Ophthalmicus. Dermatomal rash. |
| Enterovirus (Coxsackie A24, Enterovirus 70) | Acute Haemorrhagic Conjunctivitis. |
| Molluscum Contagiosum | Lid lesions. Follicular conjunctivitis. |
| Measles | Koplik spots. Keratitis. |
Mechanism
- Virus Entry: Via direct contact with infected secretions or fomites.
- Infection of Conjunctival Epithelium: Viral replication.
- Inflammatory Response: Lymphocyte infiltration. Follicles form on conjunctiva.
- Recruitment of Pre-Auricular Lymph Nodes: Lymphatic drainage.
- Corneal Involvement (Some Serotypes): Subepithelial infiltrates (Adenovirus EKC) – Can persist for months.
Why Pre-Auricular Lymph Nodes?
- The conjunctiva drains to the pre-auricular lymph nodes.
- In viral conjunctivitis (especially Adenovirus), there is a robust lymphocytic response.
Symptoms
| Symptom | Notes |
|---|---|
| Watery (Serous) Discharge | Key differentiator from bacterial (purulent). |
| Red Eye (Conjunctival Injection) | Diffuse. Often bilateral (Sequential). |
| Gritty / Foreign Body Sensation | Uncomfortable but NOT severe pain. |
| Eyelid Swelling | Mild to moderate. |
| Burning / Itching | Mild. |
| Mattering of Lids | Crusty lids in morning (Less than bacterial). |
| Recent URTI | Preceding or concurrent cold/sore throat. |
Signs
| Sign | Notes |
|---|---|
| Conjunctival Follicles | Raised, pale bumps (Lymphoid tissue) on inferior tarsal conjunctiva. |
| Pre-Auricular Lymphadenopathy | Palpable. Highly suggestive. |
| Eyelid Oedema | |
| Bilateral Involvement (Sequential) | May start unilateral, spreads. |
| Subepithelial Infiltrates (EKC) | Corneal haze. Photosensitivity. Weeks-months. |
Course
Systematic Examination
| Step | Detail |
|---|---|
| Acuity | Check visual acuity. Should be near-normal (Blurred by discharge). |
| Eyelids | Lid swelling. Check for vesicles (HSV/HZO). |
| Conjunctiva | Injection (Diffuse). Follicles (Inferior fornix). |
| Pre-Auricular Nodes | Palpate. Suggestive of viral. |
| Cornea | Fluorescein staining. Exclude Dendritic Ulcer (HSV). |
| Pupils | Should be normal. |
Fluorescein Staining (Critical)
| Finding | Interpretation |
|---|---|
| Normal | No epithelial defect. |
| Dendritic Ulcer | Branching pattern. HSV KERATITIS. Urgent. |
| Punctate Erosions | Non-specific. Seen in viral. |
| Subepithelial Infiltrates | EKC (Adenovirus). |
| Condition | Key Features |
|---|---|
| Bacterial Conjunctivitis | Purulent (Mucopurulent) discharge. Eyelids stuck together. No lymph nodes. |
| Allergic Conjunctivitis | Watery + Itchy. Bilateral. Seasonal. Cobblestone papillae. |
| HSV Keratitis | Unilateral. Vesicular lid lesions. Dendritic ulcer. Photophobia. Pain. |
| Chlamydial Conjunctivitis | Chronic. Follicles. Sexually active. Bilateral. Discharge. |
| Gonococcal Conjunctivitis | Hyperacute. Copious purulent discharge. Emergency (Corneal perforation risk). |
| Acute Angle-Closure Glaucoma | Severe pain. Halos. Mid-dilated pupil. Raised IOP. |
| Anterior Uveitis (Iritis) | Pain. Photophobia. Ciliary flush. Miosis. |
| Keratitis | Pain. Photophobia. Corneal staining. |
| Episcleritis / Scleritis | Sectoral redness (Episcleritis). Deep boring pain (Scleritis). |
Clinical Diagnosis
- Viral conjunctivitis is a clinical diagnosis.
- Investigations are rarely needed in typical cases.
When to Investigate
| Scenario | Investigation |
|---|---|
| Suspected HSV Keratitis | Slit lamp (Dendritic Ulcer). Viral swab/PCR. |
| Severe/Atypical Case | Conjunctival swab (Viral PCR). |
| Outbreak Investigation | Adenovirus PCR. |
| Contact Lens Wearer with Pain | Urgent Ophthalmology (Exclude Pseudomonas Keratitis). |
Principles
- Supportive (Self-limiting).
- Hygiene (Prevent spread).
- Exclude HSV / Serious Causes.
- NO Antibiotics.
Supportive Treatment
| Intervention | Detail |
|---|---|
| Lubricating Eye Drops | Artificial tears for comfort (e.g., Hypromellose). |
| Cold Compresses | For lid swelling. |
| Analgesia | Paracetamol for discomfort. |
Hygiene Measures (Critical)
| Measure | Rationale |
|---|---|
| Hand Hygiene | Wash hands frequently. Do not touch eyes. |
| Avoid Sharing | Towels, Pillows, Eye drops, Makeup. |
| Dispose of Tissues | Immediately after use. |
| Stay Off Work/School | Highly contagious. 2 weeks. |
| No Contact Lenses | Until fully resolved. |
What NOT to Do
| Do Not | Reason |
|---|---|
| Antibiotics | Viral. Ineffective. Resistance. |
| Steroids | Can worsen HSV. Do not give unless HSV excluded and Ophthalmology advice. |
| Share Eye Drops | Cross-contamination. |
When to Refer to Ophthalmology
| Scenario | Action |
|---|---|
| Pain / Photophobia | Urgent. Exclude Keratitis. |
| Dendritic Ulcer on Fluorescein | Urgent. HSV Keratitis. |
| Contact Lens Wearer | Urgent. Exclude Pseudomonas. |
| Visual Loss | Urgent. |
| Persistent > Weeks / Worsening | Routine. |
| Complication | Notes |
|---|---|
| Subepithelial Infiltrates (EKC) | Corneal haze. Photosensitivity. Persists weeks-months. May need steroid drops (Specialist). |
| Secondary Bacterial Infection | Rare. |
| Spread to Contacts | Outbreaks in families, schools. |
| Pseudomembrane/Membrane | Severe cases (Adenovirus). May cause scarring. |
- Self-Limiting: Resolves in 2-3 weeks.
- Vision: Usually preserved. Minor transient blur (discharge).
- Subepithelial Infiltrates (EKC): May cause glare/blur for months. Eventually resolves.
Key Guidelines
| Guideline | Organisation | Notes |
|---|---|---|
| NICE CKS: Conjunctivitis – Infective | NICE | UK Primary Care guidance. |
| College of Optometrists | UK | Red eye pathways. |
Scenario 1:
- Stem: A 25-year-old presents with a red, watery eye for 3 days. He had a cold last week. Pre-auricular lymph node is palpable. What is the most likely diagnosis?
- Answer: Viral Conjunctivitis (Probably Adenoviral).
Scenario 2:
- Stem: What is the key clinical feature differentiating viral from bacterial conjunctivitis?
- Answer: Discharge: Watery = Viral. Purulent = Bacterial. Pre-auricular lymph nodes = Viral.
Scenario 3:
- Stem: A patient with unilateral red eye has severe photophobia and vesicular lesions on the eyelid. What must you exclude?
- Answer: HSV Keratitis. Perform fluorescein staining – Look for Dendritic Ulcer.
| Scenario | Urgency | Action |
|---|---|---|
| Typical viral conjunctivitis | Routine | GP/Self-care. Supportive. Hygiene. |
| Pain / Photophobia | Urgent | Ophthalmology. Exclude Keratitis. |
| Contact Lens Wearer with Red Eye | Urgent | Ophthalmology. Exclude Pseudomonas. |
| Visual Loss | Urgent | Ophthalmology. |
| Vesicular Rash on Lid | Urgent | Ophthalmology. Exclude HSV/HZO. |
| Not Improving at 3 Weeks | Routine | Ophthalmology. |
What is Viral Conjunctivitis (Pink Eye)?
Viral conjunctivitis is an infection of the thin layer covering the white of your eye. It's usually caused by the same viruses that cause colds. It makes your eye red, watery, and uncomfortable.
Is it contagious?
Yes, very. It spreads easily through touching your eyes and then touching objects or other people. Wash your hands often and don't share towels.
How is it treated?
- It gets better on its own in 2-3 weeks.
- Use lubricating eye drops for comfort.
- No antibiotics (They don't work for viruses).
- Keep hands clean. Stay off work/school if you can.
Key Counselling Points
- No Antibiotics Needed: "This is caused by a virus, so antibiotics won't help."
- Highly Contagious: "Wash your hands frequently. Don't share towels."
- Self-Limiting: "It will get better on its own in 2-3 weeks."
- Red Flags: "Come back if you have severe pain, sensitivity to light, or blurred vision."
| Standard | Target |
|---|---|
| Antibiotic prescribing avoided in viral conjunctivitis | >0% |
| Fluorescein staining performed if pain/photophobia | 100% |
| Contact lens wearers referred urgently | 100% |
| Safety-netting advice documented | 100% |
- "Pink Eye": Common layperson term for any red eye, most often used for infectious conjunctivitis.
- Adenovirus Discovery (1950s): Adenoviruses first isolated from adenoid tissue, hence the name.
- Epidemic Keratoconjunctivitis (EKC): Recognised as a distinct, highly contagious form with corneal involvement.
- NICE CKS: Conjunctivitis – Infective. cks.nice.org.uk
- Rietveld RP, et al. Predicting bacterial cause in infectious conjunctivitis. BMJ. 2004. PMID: 15258006
Medical Disclaimer: MedVellum content is for educational purposes and clinical reference. If you have severe eye pain or vision problems, please seek urgent medical attention.