Renal Colic
Critical Alerts
- Infected obstructing stone (pyonephrosis) is a urological emergency requiring immediate decompression
- Solitary kidney obstruction risks complete renal failure
- Bilateral obstructing stones rare but can cause acute kidney injury
- Stone size >10mm unlikely to pass spontaneously - early urology referral
- NSAIDs are first-line analgesia - more effective than opioids for renal colic
Key Diagnostics
- Non-contrast CT (NCCT) abdomen/pelvis is gold standard
- Urinalysis (hematuria in 80-90%)
- BUN/Creatinine (renal function, especially if bilateral or single kidney)
- CBC if infection suspected
- Urine culture if fever or UTI symptoms
Emergency Treatments
- Analgesia: Ketorolac 15-30mg IV/IM + Acetaminophen 1g IV
- Opioids: Morphine 0.1mg/kg IV for severe pain or NSAID contraindication
- Antiemetics: Ondansetron 4-8mg IV
- IV fluids: Judicious - aggressive hydration not proven beneficial
- Medical expulsive therapy: Tamsulosin 0.4mg daily for stones 5-10mm
Renal colic refers to the acute pain caused by urinary tract stones (urolithiasis) obstructing the collecting system. The term "colic" describes the intermittent, cramping nature of the pain, though in reality, many patients experience constant severe pain with fluctuating intensity.
Stone Types
| Type | Frequency | Appearance on CT | Risk Factors |
|---|---|---|---|
| Calcium oxalate | 60-80% | Radiodense | Hypercalciuria, hyperoxaluria, low citrate |
| Calcium phosphate | 10-20% | Radiodense | Renal tubular acidosis, hyperparathyroidism |
| Uric acid | 5-10% | Radiolucent (may not see on plain film) | Gout, high purine diet, acidic urine |
| Struvite | 5-10% | Moderate density | UTI with urease-producing organisms |
| Cystine | 1-3% | Moderate density | Cystinuria (hereditary) |
Epidemiology
- Lifetime prevalence: 5-15%
- Recurrence rate: 50% within 5-10 years
- Peak incidence: Ages 20-60 years
- Sex ratio: Male > Female (2:1), gap narrowing
- Seasonal variation: More common in summer (dehydration)
Stone Location Terminology
| Term | Location |
|---|---|
| Nephrolithiasis | Kidney stone (any location) |
| Ureterolithiasis | Stone in ureter |
| Proximal ureteral | Upper 1/3 of ureter |
| Mid-ureteral | Middle 1/3 |
| Distal ureteral | Lower 1/3, near bladder |
| Ureterovesical junction (UVJ) | Most common impaction site |
Mechanism of Stone Formation
Supersaturation Theory
- Urinary concentration of stone-forming substances exceeds solubility
- Crystal nucleation occurs
- Crystal aggregation and growth
- Stone retention in collecting system
Contributing Factors
- Low urine volume (dehydration)
- Elevated urinary calcium, oxalate, uric acid
- Low urinary citrate (inhibitor)
- Urinary pH extremes (acidic = uric acid; alkaline = calcium phosphate)
- Urinary stasis
Mechanism of Pain
Acute Obstruction Cascade
- Stone impacts at narrow points (UPJ, crossing iliac vessels, UVJ)
- Ureteral peristalsis increases (attempting to expel)
- Intraluminal pressure rises
- Renal capsule distension
- Prostaglandin release → pain + ureteral spasm
- Referred pain via T10-L1 dermatomes
Pain Distribution
| Stone Location | Pain Pattern |
|---|---|
| Renal pelvis/UPJ | Flank, costovertebral angle |
| Proximal ureter | Flank radiating to abdomen |
| Mid-ureter | Lower abdomen, groin |
| Distal ureter/UVJ | Groin, testicle/labia, suprapubic |
Natural History
Spontaneous Passage Rates
| Stone Size | Passage Rate | Average Time |
|---|---|---|
| <5mm | 70-90% | Days to 4 weeks |
| 5-10mm | 20-50% | 2-4 weeks |
| >0mm | <10% | Rarely spontaneous |
Classic Presentation
Pain Characteristics
Associated Symptoms
| Symptom | Frequency | Notes |
|---|---|---|
| Nausea/vomiting | 60-80% | From visceral nerve stimulation |
| Hematuria | 80-90% | Microscopic or gross |
| Dysuria | 30-40% | Especially distal stones |
| Urinary urgency/frequency | 20-30% | Distal ureteral/UVJ stones |
| Testicular/labial pain | Common | Referred from distal ureter |
Physical Examination
Vital Signs
Examination Findings
| Finding | Significance |
|---|---|
| Costovertebral angle tenderness | Common, sensitive but not specific |
| Writhing, cannot stay still | Classic for renal colic |
| Guarding, rebound | Consider alternative diagnosis |
| Abnormal genitourinary exam | Consider torsion, epididymitis, hernia |
Atypical Presentations
Consider Alternative Diagnoses If:
Critical Presentations
| Red Flag | Concern | Action |
|---|---|---|
| Fever + obstructing stone | Infected hydronephrosis (pyonephrosis) | Emergency urology, decompression |
| Anuria | Bilateral obstruction or single kidney | Emergency imaging and urology |
| Rising creatinine | Acute kidney injury from obstruction | Urgent urology consultation |
| Sepsis | Urosepsis | Resuscitation, decompression |
| Intractable pain/vomiting | Unable to manage outpatient | Admission consideration |
| Stone >0mm | Unlikely to pass | Urology referral for intervention |
Infected Obstructing Stone (Pyonephrosis)
Clinical Features
- Flank pain + fever + rigors
- May progress rapidly to septic shock
- Urology emergency
Management
- Blood cultures, IV antibiotics
- Emergency decompression (ureteral stent or nephrostomy)
- Do NOT attempt lithotripsy until sepsis controlled
By Symptom Pattern
Flank Pain
| Condition | Distinguishing Features |
|---|---|
| Renal colic | Colicky, radiates to groin, hematuria |
| Pyelonephritis | Fever, pyuria, constant pain |
| AAA/dissection | Older, pulsatile mass, cardiovascular risk |
| Musculoskeletal | Positional, reproducible with palpation |
| Herpes zoster | Dermatomal, vesicular rash |
Lower Abdominal/Groin Pain
| Condition | Distinguishing Features |
|---|---|
| Appendicitis | RLQ, anorexia, peritoneal signs |
| Ovarian pathology | Female, mid-cycle, adnexal tenderness |
| Ectopic pregnancy | Female, positive pregnancy test |
| Testicular torsion | Scrotal pain, abnormal lie |
| Strangulated hernia | Groin mass, bowel obstruction signs |
Key Mimics to Rule Out
Abdominal Aortic Aneurysm
- Age >60, cardiovascular risk factors
- May have pulsatile mass
- Consider bedside ultrasound
- Pain may radiate to back/flank
Ectopic Pregnancy
- Always check pregnancy test in reproductive-age females
- Shoulder tip pain if ruptured
- May have hematuria
Laboratory Studies
| Test | Purpose | Findings |
|---|---|---|
| Urinalysis | Hematuria, leukocytes | RBCs in 80-90%; pyuria suggests infection |
| Urine culture | If infection suspected | Obtain before antibiotics |
| Pregnancy test | Exclude ectopic | All reproductive-age females |
| BMP | Renal function | Elevated if AKI or chronic kidney disease |
| CBC | Infection | Leukocytosis with left shift |
Urinalysis Interpretation
- Hematuria absent in 10-20% of proven stones
- Pyuria without bacteriuria common from inflammation
- WBCs + bacteria + obstruction = emergency
Imaging
Non-Contrast CT Abdomen/Pelvis (Gold Standard)
| Advantage | Limitation |
|---|---|
| Sensitivity/specificity >5% | Radiation exposure |
| Identifies all stone types | Cost |
| Shows stone size and location | May miss small UVJ stones |
| Identifies alternative diagnoses |
CT Findings
- Direct visualization of stone
- Hydronephrosis/hydroureter
- Perinephric stranding
- Rim sign around stone
- Measurement of stone size
Ultrasound
| Advantage | Limitation |
|---|---|
| No radiation | Cannot see all stones (especially ureteral) |
| Pregnancy safe | Operator dependent |
| Shows hydronephrosis | Less specific |
| Rapidly available |
When to Use Ultrasound First
- Pregnancy
- Known recurrent stone former
- Pediatric patients
- Young patients with classic presentation
Plain Radiograph (KUB)
- Limited sensitivity (50-60%)
- Cannot detect uric acid or other radiolucent stones
- Useful for follow-up of known calcium stones
Imaging Algorithm
Suspected Renal Colic
↓
Pregnancy test (if applicable)
↓
Classic presentation + hematuria?
↓
[YES] [NO or UNCERTAIN]
↓ ↓
Low-dose NCCT Standard NCCT or
OR Point-of-care consider alternative
ultrasound first diagnoses
↓
Stone confirmed?
↓
[YES] → Size assessment → Management
↓
[NO] → Consider alternative diagnoses
Repeat testing if high suspicion
Analgesia (First Priority)
First-Line: NSAIDs
Ketorolac 15-30mg IV/IM (max 30mg if >65 or renal impairment)
OR
Ibuprofen 400-800mg PO
OR
Diclofenac 50-75mg IM
+ Acetaminophen 1g IV or PO (synergistic)
Evidence: NSAIDs are MORE effective than opioids for renal colic (Cochrane 2018)
Second-Line: Opioids
Morphine 0.1 mg/kg IV
OR
Fentanyl 1-2 mcg/kg IV
Indication:
- NSAID contraindication (renal impairment, GI bleed, allergy)
- Inadequate response to NSAIDs
Antiemetics
- Ondansetron 4-8mg IV
- Metoclopramide 10mg IV
IV Fluids
Traditional vs Evidence
- Traditional teaching: "flush the stone"
- Evidence: No benefit to aggressive IV hydration
- May worsen pain if hydronephrosis present
- Use fluids for dehydration/vomiting, not routinely
Medical Expulsive Therapy (MET)
Tamsulosin 0.4mg Daily
Indication: Distal ureteral stones 5-10mm
Duration: 4-6 weeks
NNT: ~4 (for stone passage)
Evidence: AUA Guidelines 2016 support MET for distal ureteral stones ≤10mm
Other Alpha-Blockers
- Silodosin
- Alfuzosin (less evidence)
Adjunctive Medications
- Nifedipine: Limited evidence, not routinely recommended
- Corticosteroids: No longer recommended
Indications for Urology Intervention
Emergent (Hours)
- Infected obstructing stone
- Complete anuria
- Single kidney with obstruction
- Bilateral obstructing stones
Urgent (24-48 Hours)
- Stone >10mm (unlikely to pass)
- High-grade obstruction with pain
- Persistent obstruction + AKI
- Social factors (travel, athlete, etc.)
Elective Referral
- First-time stone for metabolic workup
- Recurrent stones
- Follow-up of conservative management
Surgical Options (Urology)
| Modality | Stone Size/Location | Notes |
|---|---|---|
| ESWL | <20mm, renal or upper ureter | Outpatient, non-invasive |
| Ureteroscopy | Any ureteral stone | Higher stone-free rates |
| PCNL | >0mm renal stones | Invasive but effective |
| Ureteral stent | Temporizing for obstruction | Bridge to definitive treatment |
| Nephrostomy | Infected obstruction | Emergent decompression |
Discharge Criteria (Safe for Home)
- Pain controlled with oral medications
- Tolerating oral intake
- Afebrile
- No signs of infection
- Stone <10mm with reasonable expectation of passage
- Able to follow up with urology
- Understands return precautions
Admission Criteria
- Intractable pain or vomiting
- Unable to tolerate oral intake
- Signs of infection with obstruction
- Acute kidney injury
- Single functioning kidney with obstruction
- Social factors (unable to access care if deteriorates)
Follow-up Recommendations
Discharge Instructions
- Strain all urine for stone collection
- High fluid intake (2-3L/day)
- Pain medications as prescribed
- Medical expulsive therapy if indicated
Follow-up Timeline
| Timeframe | Purpose |
|---|---|
| 24-72 hours | Urology if stone > 6-7mm or not passing |
| 1-2 weeks | Repeat imaging to assess passage |
| 4-6 weeks | Stone should have passed; urology if not |
| 3 months | With passed stone for metabolic workup |
Return Precautions
Return immediately if:
- Fever or chills
- Unable to keep fluids down for >24 hours
- Unable to urinate
- Worsening pain despite medications
- Blood in urine increasing significantly
Understanding Kidney Stones
- Kidney stones form from minerals in urine
- They cause pain as they travel through the urinary tract
- Most small stones (under 5mm) pass on their own
- Larger stones may require procedures
Stone Prevention
General Measures
- Increase fluid intake (goal: 2.5L urine output/day)
- Lemonade and orange juice increase citrate
- Limit sodium intake
- Moderate calcium intake (dietary calcium is protective!)
- Limit animal protein
Stone-Specific Prevention
| Stone Type | Prevention |
|---|---|
| Calcium oxalate | Fluids, moderate oxalate, thiazides |
| Calcium phosphate | Treat underlying condition |
| Uric acid | Fluids, decrease purines, alkalinize urine |
| Struvite | Prevent/treat UTIs |
| Cystine | High fluids, alkalinize urine |
Medication Instructions
- Take tamsulosin (if prescribed) as directed
- May cause dizziness - rise slowly from sitting/lying
- Continue until stone passes or urology follow-up
- NSAIDs can help with pain - take with food
Pregnancy
Considerations
- Stone incidence same as non-pregnant
- Most common in 2nd and 3rd trimester
- Physiologic hydronephrosis can confuse diagnosis
- Avoid CT if possible
Management
- Ultrasound first-line imaging
- MRI without contrast if needed
- Analgesia: Acetaminophen, opioids (short-term)
- Avoid NSAIDs (especially 3rd trimester)
- Urology involvement for intervention
Pediatric Patients
- Increasing incidence in children
- Consider metabolic/genetic causes
- Ultrasound first-line
- Weight-based analgesia
Patients with Single Kidney
- Any obstruction is potentially critical
- Lower threshold for imaging
- Urgent urology involvement
- Close monitoring of renal function
Recurrent Stone Formers
- May know their typical presentation
- Low-dose CT or ultrasound appropriate
- Metabolic workup essential
- Prevention strategies crucial
Performance Indicators
| Metric | Target |
|---|---|
| Time to analgesia | <30 minutes |
| Appropriate imaging (NCCT) | >0% |
| Pregnancy test before imaging (women) | 100% |
| Urology referral for stones >0mm | 100% |
| Strainer and follow-up instructions | 100% |
| MET prescribed for eligible stones | >0% |
Documentation Requirements
- Pain scale documentation
- Pregnancy test result (if applicable)
- Stone size and location from imaging
- Presence/absence of hydronephrosis
- Renal function
- Treatment provided
- Disposition rationale
- Clear follow-up plan
Diagnostic Pearls
- Absence of hematuria doesn't exclude stones - 10-20% have none
- CT is gold standard but ultrasound first in pregnancy
- Consider AAA in older patients with first episode
- Pregnancy test every female of childbearing age
- Fever + obstruction = emergency
Treatment Pearls
- NSAIDs are superior to opioids for renal colic
- Don't push fluids - no benefit, may worsen pain
- Tamsulosin helps passage for distal stones 5-10mm
- Stone <5mm = high chance of passing
- Stone >10mm = needs intervention
Disposition Pearls
- Discharge most uncomplicated cases with urology follow-up
- Strain urine - stone analysis guides prevention
- Infected obstruction = admission and decompression
- Clear return precautions are essential
- Know when to call urology emergently
- Türk C, et al. EAU Guidelines on Diagnosis and Conservative Management of Urolithiasis. Eur Urol. 2016;69(3):468-474.
- Assimos D, et al. Surgical Management of Stones: AUA/Endourology Society Guideline. J Urol. 2016;196(4):1153-1160.
- Holdgate A, Pollock T. Nonsteroidal anti-inflammatory drugs (NSAIDs) versus opioids for acute renal colic. Cochrane Database Syst Rev. 2004.
- Worster A, Richards C. Fluids and diuretics for acute ureteric colic. Cochrane Database Syst Rev. 2005.
- Pickard R, et al. Medical expulsive therapy in adults with ureteric colic: a multicentre, randomised, placebo-controlled trial. Lancet. 2015;386(9991):341-349.
- Smith-Bindman R, et al. Ultrasonography versus computed tomography for suspected nephrolithiasis. N Engl J Med. 2014;371(12):1100-1110.
| Version | Date | Changes |
|---|---|---|
| 1.0 | 2025-01-15 | Initial comprehensive version with 14-section template |